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4,4,5,5,5-Pentafluoro-1-pentanol

4,4,5,5,5-Pentafluoro-1-pentanol structure

CAS No.: 148043-73-6

Chemical Name:: 4,4,5,5,5-Pentafluoro-1-pentanol

Synonyms: 4,4,5,5,5-PENTAFLUOROPENTAN-1-OL;Pentafluoropentanol;4,4,5,5,5-PENTAFLUOROPENTANOL;Fulvestrant Impurity 31;Fulvestrant InterMediates;Fulvestrant intermediate C;1,1,5,5,5-pentafluoro-1-pentanol;4,4,5,5,5-PENTAFLUORO-1-PENTANOL;1-Pentanol,4,4,5,5,5-pentafluoro-;4,4,5,5,5-Pentafluoropentan-1-ol96%

CBNumber:: CB4232519

Molecular Formula:: C5H7F5O

Molecular Weight:: 178.1

MDL Number:: MFCD00153224

MOL File:: 148043-73-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:02:46

Product description	Number	Pack Size	Price
4,4,5,5,5-Pentafluoro-1-pentanol 95%	541133	5g	$70.1
4,4,5,5,5-Pentafluoro-1-pentanol 95%	541133	25g	$286
4,4,5,5,5-Pentafluoro-1-pentanol >93.0%(GC)	P1342	5g	$51
4,4,5,5,5-Pentafluoro-1-pentanol >93.0%(GC)	P1342	25g	$181
4,4,5,5,5-Pentafluoropentanol	TRC-P270325-5G	5g	$84
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4,4,5,5,5-Pentafluoro-1-pentanol Properties

Boiling point	62-64 °C35 mm Hg(lit.)
Density	1.35 g/mL at 25 °C(lit.)
vapor pressure	1.1-155.2hPa at 25-80.3℃
refractive index	n20/D 1.33(lit.)
Flash point	145 °F
storage temp.	2-8°C
solubility	Chloroform
pka	14.77±0.10(Predicted)
form	Liquid
color	Clear colorless
InChI	InChI=1S/C5H7F5O/c6-4(7,2-1-3-11)5(8,9)10/h11H,1-3H2
InChIKey	QROUUECTKRZFHF-UHFFFAOYSA-N
SMILES	C(O)CCC(F)(F)C(F)(F)F
LogP	1.59 at 25℃ and pH7
CAS DataBase Reference	148043-73-6(CAS DataBase Reference)
EPA Substance Registry System	3-(Perfluoroethyl)propanol (148043-73-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,F

Risk Statements

36-36/37/38

Safety Statements

26-36

RIDADR

1993

WGK Germany

Hazard Note

Irritant

HazardClass

FLAMMABLE

HS Code

29055900

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 3

REACH Registrations

Active

NFPA 704

	2
2		0

4,4,5,5,5-Pentafluoro-1-pentanol price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	541133	4,4,5,5,5-Pentafluoro-1-pentanol 95%	148043-73-6	5g	$70.1	2026-04-30	Buy
Sigma-Aldrich	541133	4,4,5,5,5-Pentafluoro-1-pentanol 95%	148043-73-6	25g	$286	2026-04-30	Buy
TCI Chemical	P1342	4,4,5,5,5-Pentafluoro-1-pentanol >93.0%(GC)	148043-73-6	5g	$51	2026-04-30	Buy
TCI Chemical	P1342	4,4,5,5,5-Pentafluoro-1-pentanol >93.0%(GC)	148043-73-6	25g	$181	2026-04-30	Buy
TRC	TRC-P270325-5G	4,4,5,5,5-Pentafluoropentanol	148043-73-6	5g	$84	2026-06-03	Buy

Product number	Packaging	Price	Buy
541133	5g	$70.1	Buy
541133	25g	$286	Buy
P1342	5g	$51	Buy
P1342	25g	$181	Buy
TRC-P270325-5G	5g	$84	Buy

4,4,5,5,5-Pentafluoro-1-pentanol Chemical Properties,Uses,Production

Description

4,4,5,5,5-Pentafluoro-1-pentanol (PFP; Pentafluoropentanol) is an essential building block primarily used in the commercial manufacture of the API. It is typically activated with a sulfonate leaving group and displaced selectively by the sulfur atom in 9-mercapto-1-nonanol to make 9-[(4,4,5,5,5-pentafluoropentyl)-thio]-1-nonanol (FVS). FVS is subsequently converted into a bromide and coupled with the steroid portion to make fulvestrant. First approved by the FDA in 2002, fulvestrant is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression.

Chemical Properties

Colorless to yellow liquid

Uses

4,4,5,5,5-Pentafluoro-1-pentanol may be used in the preparation of chlorine-capped telechelic poly(methyl methacrylate)s.

Uses

4,4,5,5,5-Pentafluoro-1-pentanol (Pentafluoropentanol) is an intermediate in preparing pentafluoropentane-1-thiol: a vital chain of anti-breast cancer agents.

General Description

4,4,5,5,5-Pentafluoro-1-pentanol, also known as pentafluoropentanol, is a perfluorous solvent.

Synthesis

Pentafluoroiodoethane could used as a starting material to synthesize 4,4,5,5,5-Pentafluoro-1-pentanol. Specific steps are as follows: under an inert gas atmosphere, iron acetylacetonate, 6,6'-dimethyl-2,2'-bipyridine, and 1,2-dichloroethane were added to the reactor, reacted at RT for 0.5 h; added allyl alcohol, cesium carbonate, pentafluoroiodoethane successively, triisopropylsilane, warmed up to 80 ℃ and reacted for 24 h. Sampling and detection confirmed that the reaction of allyl alcohol was complete, stopped the reaction, and cooled to room temperature. The excess pentafluoroiodoethane was recovered, nitrogen was introduced into the system, hydrochloric acid was added to quench the reaction, washed, separated to obtain an organic phase, distilled to remove the solvent, and rectified to obtain 4,4,5,5,5-pentafluoro Amyl alcohol. Yield: 90.4%.
4,4,5,5,5-Pentafluoro-1-pentanol

4,4,5,5,5-Pentafluoro-1-pentanol synthesis

Synthesis of 4,4,5,5,5-Pentafluoro-1-pentanol from Iodopentafluoroethane and Allyl alcohol

4,4,5,5,5-Pentafluoro-1-pentanol Preparation Products And Raw materials

Raw materials

Iodopentafluoroethane

Preparation Products

4,4,5,5,5-Pentafluoro-1-pentanol Suppliers

Global( 312)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Lewoo Pharmatech(Shanghai)Co.,Ltd	+86-15800805830	miao@lewoopharma.com.cn	China	184	58
Liaoning Pharmaceutical Innovation Co., Ltd	+86-16588669988	sales@pipharma.com.cn	China	151	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	13343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Tianjin Huiren Chemtech Co., Ltd	+86-86-22-23707858 +86-86-13672008665	huirentech@foxmail.com	China	171	58

Supplier	Advantage
Lewoo Pharmatech(Shanghai)Co.,Ltd	58
Liaoning Pharmaceutical Innovation Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
Fluoropharm Co., Ltd.	60
career henan chemical co	58
Tianjin Huiren Chemtech Co., Ltd	58

View Lastest Price from 4,4,5,5,5-Pentafluoro-1-pentanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	4,4,5,5,5-Pentafluoro-1-pentanol 148043-73-6		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-04-15	4,4,5,5,5-Pentafluoro-1-pentanol 148043-73-6	$65.00	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd
2025-04-04	4,4,5,5,5-Pentafluoro-1-pentanol 148043-73-6		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

4,4,5,5,5-Pentafluoro-1-pentanol
148043-73-6
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

4,4,5,5,5-Pentafluoro-1-pentanol
148043-73-6
$65.00
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

4,4,5,5,5-Pentafluoro-1-pentanol
148043-73-6
98%
Henan Aochuang Chemical Co.,Ltd.

4,4,5,5,5-Pentafluoro-1-pentanol Spectrum

4,4,5,5,5-Pentafluoro-1-pentanol(148043-73-6)¹HNMR

148043-73-6(4,4,5,5,5-Pentafluoro-1-pentanol)Related Search:

4,4,5,5,5-pentafluoropentane-1-thiol Perfluoropentanoic acid ETHYL PENTAFLUOROPROPIONYLACETATE 4,4,5,5,5-Pentafluoro-1-pentanol Fenipentol

ISOAMYL ALCOHOL 1-Pentanol ALLYL PERFLUOROPENTANOATE 2,3,3,3-TETRAFLUORO-2-(PERFLUOROPENTOXY)PROPAN-1-OL (NONAFLUORO-N-BUTYL)EPOXIDE

1H,1H-HEPTAFLUOROBUTYL EPOXIDE PERFLUORO-2-TRIFLUOROMETHYL-4-OXANONANE ETHYL PERFLUOROPENTANOATE 1H,1H-PERFLUOROPENTAN-1-OL METHYL NONAFLUOROVALERATE

METHYL PENTAFLUOROPROPIONYLACETATE 2,2,3,3,4,4,5,5,5-NONAFLUOROPENTYL 2,5,7-TRINITRO-9-OXO-9H-FLUORENE-4-CARBOXYLATE METHYL-3,3-DIMETHOXY-3-(PERFLUOROBUTYL)PROPANOATE

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4,4,5,5,5-PENTAFLUORO-1-PENTANOL 4,4,5,5,5-Pentafluoropentan-1-ol 96% 4,4,5,5,5-Pentafluoropentan-1-ol96% Fulvestrant intermediate C Fulvestrant Impurity 31 1,1,5,5,5-pentafluoro-1-pentanol 4,4,5,5,5-pentafluoropentyl alcohol 4,4,5,5,5-Pentafluoro-1-pentanol,95% Fulvestrant InterMediates 1-Pentanol,4,4,5,5,5-pentafluoro- 4,4,5,5,5-Pentafluoro-1-pentanol 95% 4,4,5,5,5-Pentafluoro-1-pentanol ,97% 4,4,5,5,5-Pentafluoropentan-1-ol, tech 5-Hydroxy-1,1,1,2,2-pentafluoropentane, 3-(Perfluoroethyl)propan-1-ol 4,4,5,5,5-Pentafluoro-1-pentanol> 4,4,5,5,5-Pentafluoro-1-pentanol(For export only) 4,4,5,5,5-PENTAFLUOROPENTAN-1-OL 4,4,5,5,5-PENTAFLUOROPENTANOL Pentafluoropentanol 148043-73-6 148-043-6 C5H7F5O C2F5CH2CH2CH2OH CF3CF2CH23OH Organic Building Blocks Oxygen Compounds Building Blocks Alcohols C2 to C6 Aliphatics Intermediates & Fine Chemicals Pharmaceuticals Alcohols C2 to C6 Oxygen Compounds Industrial/Fine Chemicals Organic Fluorides