3,4,5-Trimethoxy-trans-cinnamic acid
- CAS No.
- 20329-98-0
- Chemical Name:
- 3,4,5-Trimethoxy-trans-cinnamic acid
- Synonyms
- (E)-3,4,5-Trimethoxycinnamic Acid;AKOS BBS-00000775;RARECHEM BK HC T328;OTAVA-BB BB7119152925;Cinepazide Impurities4;Cinepazide Impurities1390;(E)-3,4,5-Trimethoxycinnam;(E)-3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxycinnamic acid;trans-3,4,5-TriMethoxycinnaMic acid
- CBNumber:
- CB4236421
- Molecular Formula:
- C12H14O5
- Molecular Weight:
- 238.24
- MDL Number:
- MFCD00004388
- MOL File:
- 20329-98-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 125-127 °C(lit.) |
|---|---|
| Boiling point | 396.4±37.0 °C(Predicted) |
| Density | 1.209±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 4.48±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+ |
| InChIKey | YTFVRYKNXDADBI-SNAWJCMRSA-N |
| SMILES | C(O)(=O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1 |
| FDA UNII | C9096D920O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | GE0722000 |
| HS Code | 2918.99.4700 |
3,4,5-Trimethoxy-trans-cinnamic acid price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T1104 | (E)-3,4,5-Trimethoxycinnamic Acid >98.0%(GC)(T) | 20329-98-0 | 25g | $52 | 2026-04-30 | Buy |
| Biosynth | VAA32998 | (E)-3,4,5-Trimethoxycinnamic Acid | 20329-98-0 | 0.25g | $250 | 2026-06-05 | Buy |
| Biosynth | VAA32998 | (E)-3,4,5-Trimethoxycinnamic Acid | 20329-98-0 | 2.5g | $855.5 | 2026-06-05 | Buy |
| ChemScene | CS-0042365 | (E)-3,4,5-Trimethoxycinnamic acid ≥98% | 20329-98-0 | 100g | $55 | 2026-06-04 | Buy |
| ChemScene | CS-0042365 | (E)-3,4,5-Trimethoxycinnamic acid ≥98% | 20329-98-0 | 500g | $169 | 2026-06-04 | Buy |
3,4,5-Trimethoxy-trans-cinnamic acid Chemical Properties, Uses, Production
Uses
(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].
Definition
ChEBI: 3,4,5-trimethoxycinnamic acid is a methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions. It has a role as an allergen. It is a conjugate acid of a 3,4,5-trimethoxycinnamate.
in vivo
(E)-3,4,5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects[2].
(E)-3,4,5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice[3].
| Animal Model: | Ault male KunMing-strain mice (18-20 g, maximal electroshock (MES) and pentylenetetrazol (PTZ) models)[2] |
| Dosage: | 5, 10 and 20 mg/kg; 10 mL/kg |
| Administration: | IP, once |
| Result: | Significantly decreased the incidence of MES-induced THE (tonic hindlimb extension) to 50% and 20% of the value of the vehicle controls at 10 and 20 mg/kg. Decreased the incidence of MES-induced THE to only 80% at 5 mg/kg. Significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. The incidence of generalized clonic convulsions (stage 4) disappeared at doses of both 10 and 20 mg/kg. |
| Animal Model: | ICR male mice (25-28 g, 10-12 in each group)[3] |
| Dosage: | 2, 5 and 10 mg/kg |
| Administration: | Orally (p.o.), once, 15 min and 1 h prior to pentobarbital injection |
| Result: | Significantly decreased locomotor activity at 10 mg/kg. Increased NREM and total sleep, but decreased wakefulness. |
IC 50
5-HT1A Receptor: 7.6 μM (IC50); 5-HT2C Receptor: 2.5 μM (IC50); 5-HT2A Receptor: >10 μM (IC50); 5-HT6 Receptor: >10 μM (IC50); 5-HT7 Receptor: >10 μM (IC50)
References
[1] Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227. DOI:10.1016/j.ejmech.2019.04.009
[2] Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131(1):1-5. DOI:10.1016/j.jphs.2015.07.021
[3] Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51. DOI:10.1007/s12272-013-0167-6
3,4,5-Trimethoxy-trans-cinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3,4,5-Trimethoxy-trans-cinnamic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zaoyang Cixiang Medical Technology Co., Ltd | 19871689299 | 1242417277@qq.com | China | 52 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mei Lan Industrial (Shanghai) Co., Ltd. | 021-58958189 | wouchina@126.com | China | 2658 | 55 |
View Latest Price from 3,4,5-Trimethoxy-trans-cinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
|
$2.00-8.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-04 | (E)-3,4,5-Trimethoxycinnamic acid
20329-98-0
|
$37.00 | 99.83% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
- $2.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- (E)-3,4,5-Trimethoxycinnamic acid
20329-98-0
- $37.00
- 99.83%
- TargetMol Chemicals Inc.
-
- 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
20329-98-0 (3,4,5-Trimethoxy-trans-cinnamic acid) Related Search:
1of4
