3,4,5-Trimethoxy-trans-cinnamic acid
- CAS No.
- 20329-98-0
- Chemical Name:
- 3,4,5-Trimethoxy-trans-cinnamic acid
- Synonyms
- (E)-3,4,5-Trimethoxycinnamic Acid;AKOS BBS-00000775;RARECHEM BK HC T328;OTAVA-BB BB7119152925;Cinepazide Impurities4;Cinepazide Impurities1390;(E)-3,4,5-Trimethoxycinnam;(E)-3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxycinnamic acid;trans-3,4,5-TriMethoxycinnaMic acid
- CBNumber:
- CB4236421
- Molecular Formula:
- C12H14O5
- Molecular Weight:
- 238.24
- MDL Number:
- MFCD00004388
- MOL File:
- 20329-98-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (E)-3,4,5-Trimethoxycinnamic Acid >98.0%(GC)(T) | T1104 | 25g | $52 |
| (E)-3,4,5-Trimethoxycinnamic Acid | VAA32998 | 0.25g | $250 |
| (E)-3,4,5-Trimethoxycinnamic Acid | VAA32998 | 2.5g | $855.5 |
| (E)-3,4,5-Trimethoxycinnamic acid ≥98% | CS-0042365 | 100g | $55 |
| (E)-3,4,5-Trimethoxycinnamic acid ≥98% | CS-0042365 | 500g | $169 |
| Melting point | 125-127 °C(lit.) |
|---|---|
| Boiling point | 396.4±37.0 °C(Predicted) |
| Density | 1.209±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 4.48±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+ |
| InChIKey | YTFVRYKNXDADBI-SNAWJCMRSA-N |
| SMILES | C(O)(=O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1 |
| FDA UNII | C9096D920O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | GE0722000 |
| HS Code | 2918.99.4700 |
3,4,5-Trimethoxy-trans-cinnamic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T1104 | (E)-3,4,5-Trimethoxycinnamic Acid >98.0%(GC)(T) | 20329-98-0 | 25g | $52 | 2026-04-30 | Buy |
| Biosynth | VAA32998 | (E)-3,4,5-Trimethoxycinnamic Acid | 20329-98-0 | 0.25g | $250 | 2026-06-05 | Buy |
| Biosynth | VAA32998 | (E)-3,4,5-Trimethoxycinnamic Acid | 20329-98-0 | 2.5g | $855.5 | 2026-06-05 | Buy |
| ChemScene | CS-0042365 | (E)-3,4,5-Trimethoxycinnamic acid ≥98% | 20329-98-0 | 100g | $55 | 2026-06-04 | Buy |
| ChemScene | CS-0042365 | (E)-3,4,5-Trimethoxycinnamic acid ≥98% | 20329-98-0 | 500g | $169 | 2026-06-04 | Buy |
3,4,5-Trimethoxy-trans-cinnamic acid Chemical Properties,Uses,Production
Uses
(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].
Definition
ChEBI: 3,4,5-trimethoxycinnamic acid is a methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions. It has a role as an allergen. It is a conjugate acid of a 3,4,5-trimethoxycinnamate.
in vivo
(E)-3,4,5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects[2].
(E)-3,4,5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice[3].
| Animal Model: | Ault male KunMing-strain mice (18-20 g, maximal electroshock (MES) and pentylenetetrazol (PTZ) models)[2] |
| Dosage: | 5, 10 and 20 mg/kg; 10 mL/kg |
| Administration: | IP, once |
| Result: | Significantly decreased the incidence of MES-induced THE (tonic hindlimb extension) to 50% and 20% of the value of the vehicle controls at 10 and 20 mg/kg. Decreased the incidence of MES-induced THE to only 80% at 5 mg/kg. Significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. The incidence of generalized clonic convulsions (stage 4) disappeared at doses of both 10 and 20 mg/kg. |
| Animal Model: | ICR male mice (25-28 g, 10-12 in each group)[3] |
| Dosage: | 2, 5 and 10 mg/kg |
| Administration: | Orally (p.o.), once, 15 min and 1 h prior to pentobarbital injection |
| Result: | Significantly decreased locomotor activity at 10 mg/kg. Increased NREM and total sleep, but decreased wakefulness. |
IC 50
5-HT1A Receptor: 7.6 μM (IC50); 5-HT2C Receptor: 2.5 μM (IC50); 5-HT2A Receptor: >10 μM (IC50); 5-HT6 Receptor: >10 μM (IC50); 5-HT7 Receptor: >10 μM (IC50)
References
[1] Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227. DOI:10.1016/j.ejmech.2019.04.009
[2] Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131(1):1-5. DOI:10.1016/j.jphs.2015.07.021
[3] Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51. DOI:10.1007/s12272-013-0167-6
3,4,5-Trimethoxy-trans-cinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3,4,5-Trimethoxy-trans-cinnamic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9050 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
View Lastest Price from 3,4,5-Trimethoxy-trans-cinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
|
$2.00-8.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-11 | (E)-3,4,5-Trimethoxycinnamic acid
20329-98-0
|
$40.00-92.00 | 99.83% | 10g | TargetMol Chemicals Inc. |
-
- 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
- $2.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3,4,5-TRIMETHOXYCINNAMIC ACID
20329-98-0
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- (E)-3,4,5-Trimethoxycinnamic acid
20329-98-0
- $40.00-92.00
- 99.83%
- TargetMol Chemicals Inc.
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