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N-(2-Hydroxyethyl)phthalimide

N-(2-Hydroxyethyl)phthalimide Structure
N-(2-Hydroxyethyl)phthalimide structure
CAS No.
3891-07-4
Chemical Name:
N-(2-Hydroxyethyl)phthalimide
Synonyms
N-(2-HYDROXYETHYL)PHTHALIMIDE;AKOS BBS-00004429;TIMTEC-BB SBB003638;2-PHTHALIMIDOETHANOL;N-Hydroxyethylphthal;Amlodipine Impurity Q;Alogliptin impurity Q;N-hydroethyl phthalimide;N-HYDROXYETHYLPHTHALIMIDE;2-Hydroxyethylphthalimide
CBNumber:
CB4241489
Molecular Formula:
C10H9NO3
Molecular Weight:
191.18
MDL Number:
MFCD00005903
MOL File:
3891-07-4.mol
MSDS File:
SDS
Last updated:2026-01-15 17:05:13
Product description Number Pack Size Price
N-(2-Hydroxyethyl)phthalimide 99% 138339 100g $103.55
N-(2-Hydroxyethyl)phthalimide >98.0%(HPLC)(N) H0245 25g $39
N-(2-Hydroxyethyl)phthalimide >98.0%(HPLC)(N) H0245 500g $317
N-(2-Hydroxyethyl)phthalimide H949490 100g $180
N-(2-Hydroxyethyl)phthalimide 97% OR923052 500g $185
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N-(2-Hydroxyethyl)phthalimide Properties

Melting point 126-128 °C(lit.)
Boiling point 326.92°C (rough estimate)
Density 1.2722 (rough estimate)
refractive index 1.5310 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 14.40±0.10(Predicted)
form Crystalline Powder
color White
BRN 147214
InChI InChI=1S/C10H9NO3/c12-6-5-11-9(13)7-3-1-2-4-8(7)10(11)14/h1-4,12H,5-6H2
InChIKey MWFLUYFYHANMCM-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=CC=C2)C(=O)N1CCO
CAS DataBase Reference 3891-07-4(CAS DataBase Reference)
FDA UNII 61842K53O1
NIST Chemistry Reference N-2-hydroxyethyl phthalimide(3891-07-4)
EPA Substance Registry System 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-26-36/37/39-24/25
WGK Germany  3
TSCA  TSCA listed
HS Code  29251900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
NFPA 704
1
0 0

N-(2-Hydroxyethyl)phthalimide price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 138339 N-(2-Hydroxyethyl)phthalimide 99% 3891-07-4 100g $103.55 2025-07-31 Buy
TCI Chemical H0245 N-(2-Hydroxyethyl)phthalimide >98.0%(HPLC)(N) 3891-07-4 25g $39 2025-07-31 Buy
TCI Chemical H0245 N-(2-Hydroxyethyl)phthalimide >98.0%(HPLC)(N) 3891-07-4 500g $317 2025-07-31 Buy
TRC H949490 N-(2-Hydroxyethyl)phthalimide 3891-07-4 100g $180 2021-12-16 Buy
Apolloscientific OR923052 N-(2-Hydroxyethyl)phthalimide 97% 3891-07-4 500g $185 2021-12-16 Buy
Product number Packaging Price Buy
138339 100g $103.55 Buy
H0245 25g $39 Buy
H0245 500g $317 Buy
H949490 100g $180 Buy
OR923052 500g $185 Buy

N-(2-Hydroxyethyl)phthalimide Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601

General Description

N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.

Synthesis

A synthetic method of N-(2-Hydroxyethyl)phthalimide. It was prepared by allowing 147.2g (1.0 mole) of phthalimide to react in an autoclave with 53.0g (1.20 moles) of ethylene oxide in the presence of 1.47g (1%) of active chromium III tri-2-ethylhexanoate (COT) and 400 ml of methylisobutyl ketone (MiBK) at 160° to 165°C for two hours. On cooling, the N-(2-Hydroxyethyl)phthalimide crystallized and was collected by filtration. A 94.7% yield of the hydroxyethyl imide was obtained.
synthesis of N-(2-Hydroxyethyl)phthalimide

N-(2-Hydroxyethyl)phthalimide synthesis

85-44-9
141-43-5
3891-07-4
Synthesis of N-(2-Hydroxyethyl)phthalimide from Phthalic anhydride and Monoethanolamine

N-(2-Hydroxyethyl)phthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2-fluoroethyl)- 2-[(2-Chlorophenyl)Methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester 2-[2-(2-METHOXY-PHENOXY)-ETHYL]-ISOINDOLE-1,3-DIONE Methanesulfonic acid, trifluoro-, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl ester

N-(2-Hydroxyethyl)phthalimide Suppliers

Global( 418)Suppliers
Supplier Tel Email Country ProdList Advantage
YiZheng HaiFan Chemical CO., LTD.
+86-13852506708 +86-13852506708 zcw@yzhaifan.com China 53 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5242 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13799 58
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Supplier Advantage
YiZheng HaiFan Chemical CO., LTD.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Shanghai Time Chemicals CO., Ltd. 		55
career henan chemical co 		58

View Lastest Price from N-(2-Hydroxyethyl)phthalimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-(2-hydroxyethyl)phthalimide pictures 2026-02-15 N-(2-hydroxyethyl)phthalimide
3891-07-4
 US $0.00 / kgs/paper bag 25kgs/paper bag 99% 20 tons YiZheng HaiFan Chemical CO., LTD.
N-Hydroxyethylphthalimide pictures 2026-01-30 N-Hydroxyethylphthalimide
3891-07-4
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
N-Hydroxyethylphthalimide pictures 2025-11-19 N-Hydroxyethylphthalimide
3891-07-4
 US $0.00 / kg 1kg 98% 500kg Shanghai Joiny Pharmaceutical Co.,LTD

N-(2-Hydroxyethyl)phthalimide Spectrum

N-Hydroxyethylphthalimide(3891-07-4)1HNMRN-Hydroxyethylphthalimide(3891-07-4)13CNMRN-Hydroxyethylphthalimide(3891-07-4)IR1N-Hydroxyethylphthalimide(3891-07-4)Raman

3891-07-4(N-(2-Hydroxyethyl)phthalimide)Related Search:

3-Nitrophthalimide Bismaleimide N-Methylphthalimide Succinimide 4-Nitrophthalimide
2-(METHYLSULFONYL)ETHANOL Methyl 2-hydroxyethyl cellulose Hydroxyethyl starch Hydroxyethyl Cellulose O-Phthalimide
4-Aminophthalimide N-Hydroxyphthalimide Aztreonam Amide N-CHLOROSACCHARIN N-(Hydroxymethyl)phthalimide
Potassium phthalimide Desmethyl amolodipine Amlodipine Impurity 26

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AKOS BBS-00004429 2-PHTHALIMIDOETHANOL 2-(2-hydroxyethyl)-1h-isoindole-1,3(2h)-dione N-HYDROXYETHYLPHTHALIMIDE N-(2-HYDROXYETHYL)PHTHALIMIDE N-(BETA-HYDROXYETHYL)PHTHALIMIDE TIMTEC-BB SBB003638 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- 2-(2-hydroxyethyl)-1h-isoindole-3(2h)-dione 2-Hydroxyethylphthalimide Phthalimide, N-(2-hydroxyethyl)- N- hydroxyethyl ortho - two - methimide AMlodipine Related IMpurity 6 (N-(2-Hydroxyethyl)phthaliMide) N-(2-Hydroxyethyl)phthaliMide, >=97.0% N-(2-Hydroxyethyl)phthalimide N-(2-Hydroxyethyl)phthalimide 99% N-hydroethyl phthalimide N-(2-Hydroxyethyl)phthalimide, 98+% N-(2-Hydroxyethyl)phthalimide,99% N-Hydroxyethylphthal N-(2-Hydroxyethyl)phthaliMide, 99% 25GR Amlodipine Impurity Q N-(2-Hydroxyethyl)phthalimide> Alogliptin impurity Q N-(2-Hydroxylethyl) Phthalimide N-(2-Hydroxyethyl)phthalimide (Imide) 2-(3,3-dimethylbutan-2-ylcarbamoyl)benzoic acid N-(2-HYDROXYETHYL) PHTHALIMIDE For synthesis N-Hydroxyethylphthalimide End use: Phthaloyl Amlodipine 3891-07-4 891-07-4 389-07-4 3891-7-4 727-38-4 Organic Building Blocks Cyclic Imides N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides Building Blocks Carbonyl Compounds ALCOHOL Building Blocks Carbonyl Compounds Chemical Synthesis Cyclic Imides Organic Building Blocks N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides bc0001