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N-(2-Hydroxyethyl)phthalimide

N-(2-Hydroxyethyl)phthalimide Structure
N-(2-Hydroxyethyl)phthalimide structure
CAS No.
3891-07-4
Chemical Name:
N-(2-Hydroxyethyl)phthalimide
Synonyms
N-HYDROXYETHYLPHTHALIMIDE;N-(2-HYDROXYETHYL)PHTHALIMIDE;1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)-;N-(2-Hydroxylethyl) Phthalimide;AKOS BBS-00004429;TIMTEC-BB SBB003638;2-PHTHALIMIDOETHANOL;N-Hydroxyethylphthal;Amlodipine Impurity Q;Alogliptin impurity Q
CBNumber:
CB4241489
Molecular Formula:
C10H9NO3
Molecular Weight:
191.18
MDL Number:
MFCD00005903
MOL File:
3891-07-4.mol
MSDS File:
SDS
Last updated:2026-05-28 03:14:50
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N-(2-Hydroxyethyl)phthalimide Properties

Melting point 126-128 °C(lit.)
Boiling point 326.92°C (rough estimate)
Density 1.2722 (rough estimate)
refractive index 1.5310 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Crystalline Powder
pka 14.40±0.10(Predicted)
color White
BRN 147214
InChI InChI=1S/C10H9NO3/c12-6-5-11-9(13)7-3-1-2-4-8(7)10(11)14/h1-4,12H,5-6H2
InChIKey MWFLUYFYHANMCM-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=CC=C2)C(=O)N1CCO
CAS DataBase Reference 3891-07-4(CAS DataBase Reference)
FDA UNII 61842K53O1
NIST Chemistry Reference N-2-hydroxyethyl phthalimide(3891-07-4)
EPA Substance Registry System 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-26-36/37/39-24/25
WGK Germany  3
TSCA  TSCA listed
HS Code  29251900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
REACH Registrations Active
NFPA 704
1
0 0

N-(2-Hydroxyethyl)phthalimide price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 138339 N-(2-Hydroxyethyl)phthalimide 99% 3891-07-4 100g $116 2026-04-30 Buy
TCI Chemical H0245 N-(2-Hydroxyethyl)phthalimide >98.0%(HPLC)(N) 3891-07-4 25g $39 2026-04-30 Buy
TCI Chemical H0245 N-(2-Hydroxyethyl)phthalimide >98.0%(HPLC)(N) 3891-07-4 500g $317 2026-04-30 Buy
TRC TRC-H949490-50G N-(2-Hydroxyethyl)phthalimide 3891-07-4 50g $167 2026-06-03 Buy
TRC TRC-H949490-250G N-(2-Hydroxyethyl)phthalimide 3891-07-4 250g $440 2026-06-03 Buy
Product number Packaging Price Buy
138339 100g $116 Buy
H0245 25g $39 Buy
H0245 500g $317 Buy
TRC-H949490-50G 50g $167 Buy
TRC-H949490-250G 250g $440 Buy

N-(2-Hydroxyethyl)phthalimide Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601

General Description

N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.

Synthesis

A synthetic method of N-(2-Hydroxyethyl)phthalimide. It was prepared by allowing 147.2g (1.0 mole) of phthalimide to react in an autoclave with 53.0g (1.20 moles) of ethylene oxide in the presence of 1.47g (1%) of active chromium III tri-2-ethylhexanoate (COT) and 400 ml of methylisobutyl ketone (MiBK) at 160° to 165°C for two hours. On cooling, the N-(2-Hydroxyethyl)phthalimide crystallized and was collected by filtration. A 94.7% yield of the hydroxyethyl imide was obtained.
synthesis of N-(2-Hydroxyethyl)phthalimide

N-(2-Hydroxyethyl)phthalimide synthesis

85-44-9
141-43-5
3891-07-4
Synthesis of N-(2-Hydroxyethyl)phthalimide from Phthalic anhydride and Monoethanolamine

N-(2-Hydroxyethyl)phthalimide Preparation Products And Raw materials

Raw materials

Phthalic anhydride Monoethanolamine

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2-fluoroethyl)- 2-[(2-Chlorophenyl)Methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester 2-[2-(2-Methoxy-phenoxy)-ethyl]-isoindole-1,3-dione Methanesulfonic acid, trifluoro-, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl ester

N-(2-Hydroxyethyl)phthalimide Suppliers

Global( 430)Suppliers
Supplier Tel Email Country ProdList Advantage
Heze Qiangfa Biotechnology Co., Ltd. 13569032589 624960936@qq.com China 1 58
XI'AN VEDA CHEMICAL CO.,LTD 029-88665278 18392371173 cordelia@vedachem.com China 50 58
Shanghai YouPeng Chemical Co. Ltd. 021-69005955 13701776567; youpengchem@163.com China 4153 56
YiZheng HaiFan Chemical CO., LTD. 0514-83468749 13852506708 zcw@yzhaifan.com China 49 58
shandongbaqianhehuagong 15865655795 263501023@qq.com China 57 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
New Energy Chemicals 0515-82159099 13770142076 info@njuchem.com China 251 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Supplier Advantage
Heze Qiangfa Biotechnology Co., Ltd. 58
XI'AN VEDA CHEMICAL CO.,LTD 58
Shanghai YouPeng Chemical Co. Ltd. 56
YiZheng HaiFan Chemical CO., LTD. 58
shandongbaqianhehuagong 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
New Energy Chemicals 65
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56

View Lastest Price from N-(2-Hydroxyethyl)phthalimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-(2-hydroxyethyl)phthalimide pictures 2026-09-11 N-(2-hydroxyethyl)phthalimide
3891-07-4
 25kgs/paper bag 99% 20 tons YiZheng HaiFan Chemical CO., LTD.
N-(Hydroxyethyl)phthalimide pictures 2026-09-01 N-(Hydroxyethyl)phthalimide
3891-07-4
 1kg 99% 10000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
N-Hydroxyethylphthalimide pictures 2026-08-25 N-Hydroxyethylphthalimide
3891-07-4
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

N-(2-Hydroxyethyl)phthalimide Spectrum

N-Hydroxyethylphthalimide(3891-07-4)1HNMRN-Hydroxyethylphthalimide(3891-07-4)13CNMRN-Hydroxyethylphthalimide(3891-07-4)IR1N-Hydroxyethylphthalimide(3891-07-4)Raman

3891-07-4(N-(2-Hydroxyethyl)phthalimide)Related Search:

N-Hydroxyphthalimide 3-Nitrophthalimide Bismaleimide N-Methylphthalimide Succinimide
4-Nitrophthalimide Methyl 2-hydroxyethyl cellulose Hydroxyethyl starch Hydroxyethyl Cellulose 4-Aminophthalimide
Aztreonam Amide N-(Hydroxymethyl)phthalimide Potassium phthalimide Phthalimide 2-(Methylsulfonyl)ethanol
N-Chlorosaccharin Desmethyl amolodipine Amlodipine Impurity 26

1of4

AKOS BBS-00004429 2-PHTHALIMIDOETHANOL 2-(2-hydroxyethyl)-1h-isoindole-1,3(2h)-dione N-(2-HYDROXYETHYL)PHTHALIMIDE N-(BETA-HYDROXYETHYL)PHTHALIMIDE TIMTEC-BB SBB003638 2-(2-hydroxyethyl)-1h-isoindole-3(2h)-dione 2-Hydroxyethylphthalimide Phthalimide, N-(2-hydroxyethyl)- N- hydroxyethyl ortho - two - methimide AMlodipine Related IMpurity 6 (N-(2-Hydroxyethyl)phthaliMide) N-(2-Hydroxyethyl)phthaliMide, >=97.0% N-(2-Hydroxyethyl)phthalimide N-(2-Hydroxyethyl)phthalimide 99% N-hydroethyl phthalimide N-(2-Hydroxyethyl)phthalimide, 98+% N-(2-Hydroxyethyl)phthalimide,99% N-Hydroxyethylphthal N-(2-Hydroxyethyl)phthaliMide, 99% 25GR Amlodipine Impurity Q N-(2-Hydroxyethyl)phthalimide> Alogliptin impurity Q N-(2-Hydroxyethyl)phthalimide (Imide) 2-(3,3-dimethylbutan-2-ylcarbamoyl)benzoic acid N-(2-HYDROXYETHYL) PHTHALIMIDE For synthesis N-Hydroxyethylphthalimide End use: Phthaloyl Amlodipine 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- N-(2-Hydroxylethyl) Phthalimide N-HYDROXYETHYLPHTHALIMIDE 2-(2-hydroxyethyl)isoindole-1,3-dione 3891-07-4 891-07-4 389-07-4 3891-7-4 727-38-4 Organic Building Blocks Cyclic Imides N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides Building Blocks Carbonyl Compounds ALCOHOL Building Blocks Carbonyl Compounds Chemical Synthesis Cyclic Imides Organic Building Blocks N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides bc0001