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ChemicalBook >> CAS DataBase List >>4-(4-Bromopyrimidin-2-yl)morpholine

4-(4-Bromopyrimidin-2-yl)morpholine

4-(4-Bromopyrimidin-2-yl)morpholine Structure
4-(4-Bromopyrimidin-2-yl)morpholine structure
CAS No.
663194-10-3
Chemical Name:
4-(4-Bromopyrimidin-2-yl)morpholine
Synonyms
4-(4-Bromopyrimidin-2-yl);4-BROMO-2-MORPHOLINOPYRIMIDINE;4-(4-Bromopyrimidin-2-yl)morpholine;4-(4-Bromo-2-pyrimidinyl)morpholine;Morpholine, 4-(4-bromo-2-pyrimidinyl)-;4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE ISO 9001：2015 REACH
CBNumber:
CB42448264
Molecular Formula:
C8H10BrN3O
Molecular Weight:
244.09
MDL Number:
MFCD03861153
MOL File:
663194-10-3.mol
Last updated:2026-09-12 18:52:40
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4-(4-Bromopyrimidin-2-yl)morpholine Properties

Boiling point 382.8±52.0 °C(Predicted)
Density 1.570±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 3.03±0.40(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

4-(4-Bromopyrimidin-2-yl)morpholine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 072239 4-(4-Bromopyrimidin-2-yl)morpholine 663194-10-3 250.00mg $260 2026-05-18 Buy
Matrix Scientific 072239 4-(4-Bromopyrimidin-2-yl)morpholine 663194-10-3 1.00g $559 2026-05-18 Buy
Matrix Scientific 072239 4-(4-Bromopyrimidin-2-yl)morpholine 663194-10-3 5.00g $1519 2026-05-18 Buy
aablocks AA006NE4 4-(4-Bromopyrimidin-2-yl)morpholine 97% 663194-10-3 250mg $12 2026-05-28 Buy
aablocks AA006NE4 4-(4-Bromopyrimidin-2-yl)morpholine 97% 663194-10-3 1g $39 2026-05-28 Buy
Product number Packaging Price Buy
072239 250.00mg $260 Buy
072239 1.00g $559 Buy
072239 5.00g $1519 Buy
AA006NE4 250mg $12 Buy
AA006NE4 1g $39 Buy

4-(4-Bromopyrimidin-2-yl)morpholine Chemical Properties, Uses, Production

Synthesis

Morpholine

110-91-8

2,4-DIBROMOPYRIMIDINE

3921-01-5

4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

663194-10-3

4-(2-Bromopyrimidin-4-yl)morpholine

1209459-32-4

A solution of tetrahydrofuran (10 mL) of 2,4-dibromopyrimidine (438.4 mg, 1.84 mmol) and potassium carbonate (1.27 g, 9.21 mmol) was mixed and stirred at room temperature for 5 min. Subsequently, morpholine (174.8 μL, 2.03 mmol) was added dropwise and the reaction mixture continued to be stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was filtered, the filtrate was collected and the solvent was removed by concentration under reduced pressure. The crude product was purified by silica gel column chromatography using hexane and ethyl acetate as eluents to afford 4-(4-bromopyrimidin-2-yl)morpholine (28a) and 4-(2-bromopyrimidin-4-yl)morpholine (28b) in 19% and 66% yields, respectively. 4-(4-Bromopyrimidin-2-yl)morpholine (28a): white solid in 19% yield.1H NMR (500 MHz, CDCl3) δ ppm 3.74-3.77 (m, 4H), 3.79-3.83 (m, 4H), 6.70 (d, J = 4.88 Hz, 1H), 8.05 (d, J = 4.88 Hz, 1H). LCMS m/z found 246.0, [M + H]+. 4-(2-Bromopyrimidin-4-yl)morpholine (28b): white solid, 66% yield.1H NMR (500 MHz, CDCl3) δ ppm 3.66 (br.s, 4H), 3.76-3.83 (m, 4H), 6.43 (d, J = 6.35 Hz, 1H), 8.02 (d, J = 6.35 Hz, 1H).LCMS m /z found 246.0, [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 141, p. 446 - 459

4-(4-Bromopyrimidin-2-yl)morpholine synthesis

19810-79-8
663194-10-3
Synthesis of 4-(4-Bromopyrimidin-2-yl)morpholine from 2-Morpholinopyrimidin-4-ol

4-(4-Bromopyrimidin-2-yl)morpholine Preparation Products And Raw materials

Raw materials

2-Morpholinopyrimidin-4-ol Morpholine 2,4-Dibromopyrimidine Potassium carbonate Tetrahydrofuran

Preparation Products

4-(4-Bromopyrimidin-2-yl)morpholine Suppliers

Global Suppliers ( 52)
Supplier Tel Email Country ProdList Advantage
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai ChriChem Co., Ltd. 021-54880687 China 510 55
Taizhou Tongxin Bio-Tech Co., Ltd 0523-86818997 18652728585 sales@allyrise.com China 2986 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Suzhou Laing Biological Technology Co., LTD 0512-62968256 18550502935 export@laingbiotec.com China 994 58
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Zhengzhou Alfachem Co., Ltd. 0371-53765687 18937137882 3969243885@qq.com China 7734 55
Zhengzhou Acme Chemical Co., Ltd. 0371-0371-55629727 13323845623 2885676761@qq.com China 9957 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
SynAsst Chemical. 55
Shanghai ChriChem Co., Ltd. 55
Taizhou Tongxin Bio-Tech Co., Ltd 60
Bide Pharmatech Ltd. 60
Suzhou Laing Biological Technology Co., LTD 58
Shanghai Balmxy Pharmaceutical Co., Ltd 55
JW & Y Pharmlab Co., Ltd. 58
Zhengzhou Alfachem Co., Ltd. 55
Zhengzhou Acme Chemical Co., Ltd. 58
Amadis Chemical Company Limited 58

View Latest Price from 4-(4-Bromopyrimidin-2-yl)morpholine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE pictures 2026-08-20 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE
663194-10-3
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE pictures 2021-07-13 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE
663194-10-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE pictures 2021-07-10 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE
663194-10-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4-(4-Bromopyrimidin-2-yl)morpholine Spectrum

4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE(663194-10-3)1HNMR

663194-10-3 (4-(4-Bromopyrimidin-2-yl)morpholine) Related Search:

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4-BROMO-2-MORPHOLINOPYRIMIDINE 4-(4-Bromopyrimidin-2-yl) Morpholine, 4-(4-bromo-2-pyrimidinyl)- 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE ISO 9001：2015 REACH 4-(4-Bromo-2-pyrimidinyl)morpholine 4-(4-Bromopyrimidin-2-yl)morpholine 663194-10-3