Ethyl 2-fluorobenzoylformate
- CAS No.
- 1813-93-0
- Chemical Name:
- Ethyl 2-fluorobenzoylformate
- Synonyms
- ethyl 2-(2-fluorophenyl)-2-oxoacetate;Ethyl 2-fluorobenzoylformate;Ethyl (2-Fluorophenyl)(Oxo)Acetate;2-Fluoro-oxo-benzeneacetic acid ethyl ester;Benzeneacetic acid, 2-fluoro-α-oxo-, ethyl ester
- CBNumber:
- CB42450832
- Molecular Formula:
- C10H9FO3
- Molecular Weight:
- 196.18
- MDL Number:
- MFCD09801420
- MOL File:
- 1813-93-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2918300090 |
Ethyl 2-fluorobenzoylformate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC56936 | Ethyl 2-(2-fluorophenyl)-2-oxo-acetate ≥95% | 1813-93-0 | 250mg | $109 | 2026-06-04 | Buy |
| Apolloscientific | PC56936 | Ethyl 2-(2-fluorophenyl)-2-oxo-acetate ≥95% | 1813-93-0 | 1g | $232 | 2026-06-04 | Buy |
| Apolloscientific | PC56936 | Ethyl 2-(2-fluorophenyl)-2-oxo-acetate ≥95% | 1813-93-0 | 5g | $687 | 2026-06-04 | Buy |
| Matrix Scientific | 302095 | Ethyl 2-(2-fluorophenyl)-2-oxoacetate | 1813-93-0 | 250.00mg | $62 | 2026-05-19 | Buy |
| Matrix Scientific | 302095 | Ethyl 2-(2-fluorophenyl)-2-oxoacetate | 1813-93-0 | 1.00g | $137 | 2026-05-19 | Buy |
Ethyl 2-fluorobenzoylformate Chemical Properties, Uses, Production
Synthesis
1072-85-1
95-92-1
1813-93-0
To a stirred solution of 1-bromo-2-fluorobenzene (10 g, 57 mmol) in tetrahydrofuran (100 mL) was slowly added n-butyllithium (25 mL, 62.9 mmol, 2.5 M hexane solution) under nitrogen protection and at -70 °C. After maintaining the reaction at -70°C for 20 minutes, the solution was slowly added dropwise to a solution of diethyl oxalate (39 mL, 285 mmol) in tetrahydrofuran (100 mL). After the dropwise addition was completed, the reaction mixture was gradually warmed to room temperature. After continued stirring for 1 hour at room temperature, the reaction mixture was poured into water (150 mL) and extracted with ethyl acetate (2 x 100 mL). The organic phases were combined and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (240 g) with ethyl acetate/hexane (1:49) as eluent to afford the target compound ethyl 2-(2-fluorophenyl)-2-oxoacetate as a colorless oil (5.6 g, 50% yield). The product was confirmed by 1H NMR (CDCl3): δ 7.95 (m, 1H), 7.62 (m, 1H), 7.35-7.13 (m, 2H), 4.44 (q, J=7.1Hz, 2H), 1.40 (t, J=7.1Hz, 3H). The mass spectrum (ES+) showed the molecular ion peak m/z = 197 (M+H)+.
References
[1] Patent: WO2012/74784, 2012, A2. Location in patent: Page/Page column 23-24
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3726 - 3732
[3] Angewandte Chemie - International Edition, 2014, vol. 53, # 10, p. 2658 - 2661
[4] Angew. Chem., 2014, vol. 126, # 10, p. 2696 - 2699,4
Ethyl 2-fluorobenzoylformate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai HongMin Pharmaceutical Co., Ltd. | 13651987816 | hongminpharm@163.com | China | 2338 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
