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tert-Butyl 4-hydroxybutylmethylcarbamate

tert-Butyl 4-hydroxybutylmethylcarbamate Structure
tert-Butyl 4-hydroxybutylmethylcarbamate structure
CAS No.
99207-32-6
Chemical Name:
tert-Butyl 4-hydroxybutylmethylcarbamate
Synonyms
tert-butyl N-(4-hydroxybutyl)-N-methylcarbamate;4-[Boc(methyl)amino]-1-butanol;N-Boc-4-(methylamino)butan-1-ol;tert-Butyl 4-hydroxybutylmethylcarbamate;4-(N-tert-Butyloxycarbonyl-N-methylamino)butanol;(4-Hydroxy-butyl)-Methyl-carbaMic acid tert-butyl ester;Carbamic acid, (4-hydroxybutyl)methyl-, 1,1-dimethylethyl ester;Carbamic acid, N-(4-hydroxybutyl)-N-methyl-, 1,1-dimethylethyl ester
CBNumber:
CB42453161
Molecular Formula:
C10H21NO3
Molecular Weight:
203.28
MDL Number:
MFCD09953073
MOL File:
99207-32-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:40
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tert-Butyl 4-hydroxybutylmethylcarbamate Properties

storage temp. 2-8°C
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
HS Code  2924297099

tert-Butyl 4-hydroxybutylmethylcarbamate price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR918265 tert-Butyl 4-hydroxybutylmethylcarbamate 98% 99207-32-6 1g $90 2026-06-04 Buy
Apolloscientific OR918265 tert-Butyl 4-hydroxybutylmethylcarbamate 98% 99207-32-6 5g $360 2026-06-04 Buy
Apolloscientific OR918265 tert-Butyl 4-hydroxybutylmethylcarbamate 98% 99207-32-6 10g $680 2026-06-04 Buy
Apolloscientific OR918265 tert-Butyl 4-hydroxybutylmethylcarbamate 98% 99207-32-6 25g $1360 2026-06-04 Buy
Apolloscientific OR918265 tert-Butyl 4-hydroxybutylmethylcarbamate 98% 99207-32-6 100g $4438 2026-06-04 Buy
Product number Packaging Price Buy
OR918265 1g $90 Buy
OR918265 5g $360 Buy
OR918265 10g $680 Buy
OR918265 25g $1360 Buy
OR918265 100g $4438 Buy

tert-Butyl 4-hydroxybutylmethylcarbamate Chemical Properties,Uses,Production

Synthesis

4-METHYLAMINO BUTANOL

42042-68-2

Di-tert-butyl dicarbonate

24424-99-5

TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE

99207-32-6

General procedure for the synthesis of N-Boc-N-methyl-4-aminomethylbutanol from 4-(methylamino)butan-1-ol and di-tert-butyl dicarbonate: a solution of 4-(methylamino)butan-1-ol (2.76g, 26.8mmol) in triethylamine/methanol (1:7 v/v, 100mL) was stirred for 10 minutes at 0 °C. Subsequently, a solution of di-tert-butyl dicarbonate (8.76 g, 40.2 mmol) in methanol (20 mL) was added dropwise over 10 min. The reaction mixture was stirred under nitrogen protection for 1 hour. After that, the temperature of the reaction system was allowed to gradually increase to room temperature and stirring was continued overnight. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in dichloromethane and washed with deionized water. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated to afford the colorless oily product N-Boc-N-methyl-4-aminomethylbutanol (4.54 g, 84% yield), which could be used in the next reaction without further purification.1H NMR (CDCl3) δ 3.66 (t, 2H), 3.23 (t, 2H), 2.83 (s, 3H), 1.78 (br s, 1H), 1.51-1.60 (m, 4H), 1.44 (s, 9H).

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 14, p. 5819 - 5828
[2] Patent: WO2013/148230, 2013, A1. Location in patent: Page/Page column 30
[3] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7551 - 7556
[4] Patent: US4975439, 1990, A

tert-Butyl 4-hydroxybutylmethylcarbamate Preparation Products And Raw materials

Raw materials

4-Methylamino butanol 4-[(tert-Butoxycarbonyl)(methyl)amino]butanoic acid Di-tert-butyl dicarbonate (E)-N-((tert-Butoxycarbonyl)oxy)benziMidoyl cyanide Triethylamine
Methanol

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Preparation Products

tert-Butyl 4-hydroxybutylmethylcarbamate Suppliers

Global( 48)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Pengque Chemical Technology Co., LTD 15317013857 15901926503 pengque01@sina.com China 977 58
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2283 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Shanghai Sheepchem Co., Ltd. +86 (21) 6715-7650 sheepchem@163.com China 993 60
EnliPharma Technology Co., Ltd 0551-66399836 18955197623 sales@enlipharma.com China 1875 55
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9849 55
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Shanghai JingRon Chemical Technology Co., Ltd. 021-60546673 13701861782; kuanga111@sina.com China 881 58
Supplier Advantage
Shanghai Pengque Chemical Technology Co., LTD 58
Accela ChemBio Co.,Ltd. 64
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Sheepchem Co., Ltd. 60
EnliPharma Technology Co., Ltd 55
Amatek Scientific Co. Ltd. 55
Hangzhou J&H Chemical Co., Ltd. 59
JW & Y Pharmlab Co., Ltd. 58
Shanghai JingRon Chemical Technology Co., Ltd. 58

tert-Butyl 4-hydroxybutylmethylcarbamate Spectrum

TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE(99207-32-6)1HNMR

99207-32-6(tert-Butyl 4-hydroxybutylmethylcarbamate)Related Search:

N-BOC-ISONIPECOTIC ACID Boc-4-phenylpiperidine-4-carboxylic acid 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 4-Amino-1-Boc-piperidine-4-carboxylic acid 4-Boc-1-Fmoc-2-Piperazine acetic acid
1-BOC-4-METHANESULFONYLOXYMETHYL-PIPERIDINE 2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER Boc-L-glutamic acid γ-benzyl ester N-carboxyanhydride
trans-1-Boc-4-(4-chlorophenyl)-3-pyrrolidinecarboxylic acid BOC-N-ME-GLU(OBZL)-OH 1-[(TERT-BUTYL)OXYCARBONYL]-4-PHENYLPYRROLINE-3-CARBOXYLIC ACID Boc-L-transpro(4-CH2OH) 4-(4-Methoxy-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester
1-[(TERT-BUTYL)OXYCARBONYL]-4-(2-CHLOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID Fmoc-d, L-Ala(3-pyrrolidinyl-(2-N-Boc)) 1-[(TERT-BUTYL)OXYCARBONYL]-4-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLINE-3-CARBOXYLIC ACID

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(4-Hydroxy-butyl)-Methyl-carbaMic acid tert-butyl ester N-Boc-4-(methylamino)butan-1-ol Carbamic acid, (4-hydroxybutyl)methyl-, 1,1-dimethylethyl ester 4-(N-tert-Butyloxycarbonyl-N-methylamino)butanol Carbamic acid, N-(4-hydroxybutyl)-N-methyl-, 1,1-dimethylethyl ester 4-[Boc(methyl)amino]-1-butanol tert-butyl N-(4-hydroxybutyl)-N-methylcarbamate tert-Butyl 4-hydroxybutylmethylcarbamate 99207-32-6