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4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester structure

CAS No.: 183673-66-7

Chemical Name:: 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Synonyms: FMOC-PIP(BOC)-OH;1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID;Fmoc-L-Pip(Boc)-OH;1-BOC-4-FMOC-PIP-OH;FMOC-4,4-ACP(1-N-BOC);BOC-PIC(4)(4-NHBOC)-OH;1-N-Boc-4-N-Fmoc-Aminopiperi;1-BOC-4-N-FMOC-AMINO-PIPERIDINE;1-Boc-4-(Fmoc-amino)piperidine-4;1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE

CBNumber:: CB2673000

Molecular Formula:: C26H30N2O6

Molecular Weight:: 466.53

MDL Number:: MFCD01318741

MOL File:: 183673-66-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:23

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4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Properties

Melting point	80-82 °C
Boiling point	569.36°C (rough estimate)
Density	1.2464 (rough estimate)
refractive index	1.5300 (estimate)
storage temp.	Inert atmosphere,2-8°C
pka	3.80±0.20(Predicted)
Appearance	White to off-white Solid
CAS DataBase Reference	183673-66-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	10
HS Code	29225090

4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	262885	N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	183673-66-7	250mg	$446	2026-06-03	Buy
Usbiological	262885	N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	183673-66-7	500mg	$679	2026-06-03	Buy
Usbiological	262885	N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	183673-66-7	1g	$1044	2026-06-03	Buy
Usbiological	262885	N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	183673-66-7	2g	$1650	2026-06-03	Buy
Usbiological	262885	N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	183673-66-7	5g	$2696	2026-06-03	Buy

Product number	Packaging	Price	Buy
262885	250mg	$446	Buy
262885	500mg	$679	Buy
262885	1g	$1044	Buy
262885	2g	$1650	Buy
262885	5g	$2696	Buy

4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Chemical Properties, Uses, Production

Chemical Properties

N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylic Acid is white to cream crystalline powder or chunks

Uses

N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylic acid is used in the preparation of synthetic peptide amides as kappa opioid receptor agonists for treatment of pain, pruritis and inflammation associated w ith a variety of diseases.

Uses

Cyclic ,-disubstituted amino acid for the preparation of water-soluble highly helical peptides.

Synthesis

28920-43-6

4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID

183673-71-4

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

183673-66-7

The general procedure for the synthesis of 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid from methyl chloroformate-9-fluorenylmethyl and 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid was as follows: 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (5 g, 20.5 mmol) was dissolved in THF (300 mL), an aqueous solution of Na2CO3 (6.45 g, 61.5 mmol, 3.0 eq.) was added (64.5 mL) and cooled to 0 °C. A THF solution (30 mL) of methyl 9-fluorenyl chloroformate (5.3 g, 30.7 mmol, 1.5 eq.) was added slowly and dropwise. The reaction mixture was gradually warmed to 25 °C and stirring was continued for 12 hours. After completion of the reaction, the reaction solution was carefully acidified with 1 M HCl and the crude product was extracted three times with EtOAc. The organic layers were combined, dried with Na2SO4, concentrated and purified by combiflash column chromatography (eluent: 0 to 10% MeOH/DCM) to afford the target product 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid (4.02 g, 42% yield). The product was confirmed by 1H NMR, 13C NMR and HRMS characterization.

References

[1] Organic Syntheses, 2005, vol. 81, p. 213 - 224
[2] Patent: WO2015/184349, 2015, A2. Location in patent: Paragraph 0225-0226

4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Preparation Products And Raw materials

Raw materials

9-Fluorenylmethyl chloroformate 4-Amino-1-Boc-piperidine-4-carboxylic acid Sodium carbonate Tetrahydrofuran

Preparation Products

4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Suppliers

Global Suppliers ( 181)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Suzhou haiyu Biochem Industrial Co., LTD	512-68097639 18013585858	744942877@qq.com	China	915	62
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
Suzhou haiyu Biochem Industrial Co., LTD	62
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60

View Latest Price from 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-08	4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 183673-66-7	$31.00-85.00		99.90%	10g	TargetMol Chemicals Inc.
	2020-01-05	4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 183673-66-7	$7.00	1KG	99%	100KG	Career Henan Chemical Co

4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
183673-66-7
$31.00-85.00
99.90%
TargetMol Chemicals Inc.

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
183673-66-7
$7.00
99%
Career Henan Chemical Co

4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Spectrum

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER(183673-66-7)¹HNMR

183673-66-7 (4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester) Related Search:

1-Boc-4-Methylaminopiperidine 1-Amino-1-cyclohexanecarboxylic acid 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde tert-Butyl N-(3-aminopropyl)-N-methylcarbamate N-Boc-4-piperidinemethanol

Fmoc-Aib-OH Propamocarb Isopropyl 4-aminopiperidine-1-carboxylate 4-Amino-1-Boc-piperidine 1-Boc-piperidine

Ethyl 4-hydroxypiperidine-1-carboxylate Nα-Fmoc-Nγ-Boc-D-2,4-diaminobutyric acid Fmoc-Dab(Boc)-OH 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Fmoc-Dab-OH HCl

Fmoc-D-Dab-OH N-Boc-isonipecotic acid 1-Boc-4-methylpiperidine

1of4

1-(TERT-BUTOXYCARBONYL)-4-([(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO)PIPERIDINE-4-CARBOXYLIC ACID 1-(TERT-BUTOXYCARBONYL)-4-FLUORENYLMETHOXYCARBONYLAMINOPIPERIDINE-4-CARBOXYLIC ACID 1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE 1-N-BOC-4-N-FMOC-AMINOPIPERIDINE-4-CARBOXYLIC ACID 1-BOC-4-FMOC-PIP-OH 1-BOC-4-(FMOC-AMINO)-PIPERIDINE-4-CARBOXYLIC ACID 4-(FMOC-AMINO)-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-[[(9H-Fluoren-9-ylMethoxy)carbonyl]aMino]-1,4-piperidinedicarboxylic Acid 1-(1,1-DiMethylethyl) Ester 1-BOC-4-N-FMOC-AMINO-PIPERIDINE 1-Boc-4-(FMoc-aMino)-4-piperidinecarboxylic acid BOC-PIC(4)(4-NHBOC)-OH FMOC-4,4-ACP(1-N-BOC) FMOC-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID N-ALPHA,GAMMA-DI-T-BUTOXYCARBONYL-4-AMINO-4-PIPECOLIC ACID N-BOC-4-N-FMOC-AMINO-4-PIPERIDINYLCARBOXYLIC ACID N-BOC-4-(FMOC-AMINO)PIPERIDINE-4-CARBOXYLIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-AMINO-(4-N-(TERT-BUTOXYCARBONYL)-PIPERIDINYL)CARBOXYLIC ACID 1-[(tert-butoxy)carbonyl]-4-[(9H-fluoren-9-ylMethoxy)carbonyl]piperidine-4-carboxylic acid 1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-piperidinecarboxylic acid N-FMOC-AMINO-(4-N-BOC-PIPERIDINYL) CARBOXYLIC ACID 4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 4-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic aci 1-Boc-piperidine-4-Fmoc-amino-4-carboxylic acid≥ 97% (HPLC) Fmoc-L-Pip(Boc)-OH 1-Boc-4-(N-Fmoc-amino)piperidine-4-carboxylic acid 1,4-Piperidinedicarboxylicacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,1-(1,1-dimethylethyl)ester(9CI) 1-Boc-piperidine-4-N-Fmoc-amino-4-carboxylicacid N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylicacid,95% 1-N-Boc-4-N-Fmoc-Aminopiperi 4-N-Fmoc-amino-1-N-Bocpiperidine-4-carboxylic acid 1-(N-Boc)-4-(Fmoc-amino)-piperidine-4-carboxylic acid 4-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylicaci 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER USP/EP/BP 4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid 1-Boc-4-(Fmoc-amino)piperidine-4 1-(1,1-Dimethylethyl) 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-piperidinedicarboxylate 1-Boc-Pi'ceridine-4-Fmoc-amino-4-carboxylic acid 4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester, 10 mM in DMSO 1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID FMOC-PIP(BOC)-OH 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 183673-66-7 83673-66-7 C26H30N2O6 Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Others Heterocycles Others Peptide Synthesis Unnatural Amino Acid Derivatives FMOC amino acids Amino Acid Derivatives Amino Acids & Derivatives