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MK-677

MK-677 Structure
MK-677 structure
CAS No.
159752-10-0
Chemical Name:
MK-677
Synonyms
nicotinamide mononucleotide powder;MK-667;IBUTAMORIN;MK-677(Ibutamoren);Ibutamoren mesilate;MK677 MK 677 IBUTAMOREN;MK677（Ibutamoren Mesylate）;MK-677; CRESCENDO; MK 0677; MK-0677; MK0677;MK677;MK 677;CS-1402;MK-0667
CBNumber:
CB42463801
Molecular Formula:
C28H40N4O8S2
Molecular Weight:
624.77
MDL Number:
MFCD00942284
MOL File:
159752-10-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 09:30:42
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MK-677 Properties

Melting point 164-170°C
storage temp. 2-8°C
solubility H2O: soluble5mg/mL, clear
form powder
color white to beige
Water Solubility H2O: 5mg/mL, clear
InChIKey DUGMCDWNXXFHDE-VZYDHVRKSA-N
SMILES S(O)(=O)(=O)C.S(N1C2C=CC=CC=2C2(CCN(C(=O)[C@H](NC(=O)C(N)(C)C)COCC3C=CC=CC=3)CC2)C1)(=O)(=O)C |&1:19,r|
FDA UNII R90JB6QJ2B
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
RTECS  TX1404490
Storage Class 11 - Combustible Solids

MK-677 price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0993 MK-677 ≥98% (HPLC) 159752-10-0 5mg $165 2026-04-30 Buy
Sigma-Aldrich SML0993 MK-677 ≥98% (HPLC) 159752-10-0 25mg $691 2026-04-30 Buy
Cayman Chemical 18003 Ibutamoren (mesylate) ≥98% 159752-10-0 5mg $94 2026-04-30 Buy
Cayman Chemical 18003 Ibutamoren (mesylate) ≥98% 159752-10-0 10mg $174 2026-04-30 Buy
Cayman Chemical 18003 Ibutamoren (mesylate) ≥98% 159752-10-0 25mg $412 2026-04-30 Buy
Product number Packaging Price Buy
SML0993 5mg $165 Buy
SML0993 25mg $691 Buy
18003 5mg $94 Buy
18003 10mg $174 Buy
18003 25mg $412 Buy

MK-677 Chemical Properties, Uses, Production

Description

MK-677 (also known as ibutamoren), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain. Clinical studies describe only the effects ibutamoren has on appetite and as expected, like ghrelin, ibutamoren increases it. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition.

Benefits

The benefits of MK-677 include muscle-building, a reduction in muscle wasting, better bone density, improved sleep, and anti-aging properties. It may also have nootropic effects and it can be beneficial in treating growth hormone deficiencies. 

Uses

Growth hormone releasing factor.MK-677 is a potent, non-peptide ghrelin receptor agonist.

Biochem/physiol Actions

It is also known as ibutamoren mesylate. MK-677 is a mimic of growth hormone (GH)-releasing peptide and is orally active.

Side effects

Reported side effects of MK-677 are typically the result of unnaturally high levels of growth hormone in the body from taking too much too often, which include:
Increased appetite
Lethargy
Joint pain if you have previous medical conditions or elevated hormone levels
Insulin resistance
Possible increase in prolactin levels, which can be controlled
When dosed properly, the side effects of MK-677 are minimal to none compared to the results you get from taking it properly. 

Synthesis

Ibutamoren mesilate (MK-677) is synthesized by sulfonylation of 1’-methyl-1,2-dihydrospiro[3H-indole-3,4’-piperidine], followed by demethylation, coupling with N-Boc-O-benzyl-D-serine, acidic cleavage, coupling with N-Boc-2-aminoisobutyric acid, deprotection, and isolation as the mesylate salt.
Synthesis of MK-677

storage

Store at -20°C

MK-677 Preparation Products And Raw materials

Raw materials

Preparation Products

MK-677 Suppliers

Global Suppliers ( 252)
Supplier Tel Email Country ProdList Advantage
Hunan Fengdu Biotechnology Co., Ltd 13533334465 396587392@qq.com China 28 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Heterochem 027-88041443 13072715837 sales@hetero-chem.com China 695 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Supplier Advantage
Hunan Fengdu Biotechnology Co., Ltd 58
Chembest Research Laboratories Limited 61
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Heterochem 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
AdooQ BioScience, LLC 58

Related articles

Related Questions

Ask a question
Q:Does MK-677 promote height growth?Qing - Mar 31,2026
A:MK-677 (Ibutamoren mesylate) is an orally active, non-peptide growth hormone secretagogue and ghrelin receptor agonist that mimics the action of growth hormone-releasing peptides, thereby significantly elevating endogenous levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It cannot induce height growth in adults whose epiphyseal plates have already fused, as height increase depends on the proliferation of epiphyseal cartilage, and the skeleton ceases to elongate longitudinally once epiphyseal fusion occurs in adulthood. For children or adolescents whose epiphyseal plates have not yet fused, its effect of elevating GH and IGF-1 levels could theoretically aid in height growth; however, there is currently a lack of high-quality clinical studies confirming its safety and efficacy. Furthermore, this substance has not been approved by major global regulatory bodies for use as a growth aid, and it carries various health risks, including edema, elevated blood glucose levels, and endocrine disruption.

View Latest Price from MK-677 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK-677 pictures 2026-09-17 MK-677
159752-10-0
 $5.00 1Box 99.99% 20000 boxes Hebei Jiafan Trading Company Limited
MK677 pictures 2026-09-17 MK677
159752-10-0
 $5.00 1Box 99.99% 20000 boxes Hebei Jiafan Trading Company Limited
MK677 pictures 2026-09-17 MK677
159752-10-0
 $9.00 10VIAL 99.9% 10000 Guangzhou XinPeptide International Co.,Ltd
  • MK-677 pictures
  • MK-677
    159752-10-0
  • $5.00
  • 99.99%
  • Hebei Jiafan Trading Company Limited
  • MK677 pictures
  • MK677
    159752-10-0
  • $5.00
  • 99.99%
  • Hebei Jiafan Trading Company Limited
  • MK677 pictures
  • MK677
    159752-10-0
  • $9.00
  • 99.9%
  • Guangzhou XinPeptide International Co.,Ltd

MK-677 Spectrum

MK-677(159752-10-0)1HNMR

159752-10-0 (MK-677) Related Search:

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Metandienone CHEMBRDG-BB 4011924 CHEMBRDG-BB 4009817 2-[(2-amino-2-methyl-propyl)amino]ethanol MK-677
N-Methyl-N-(4-piperidinylmethyl)-methanesulfonamide 2-(4-Phenylpiperidin-1-yl)ethanamine N-(Piperidinoethyl)ethylenediamine Spiro[indoline-3,4'-piperidine] MK-677
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine

1of4

2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate MK677（Ibutamoren Mesylate） MK-677; CRESCENDO; MK 0677; MK-0677; MK0677;MK677;MK 677 CS-1402 MK677 MK 677 IBUTAMOREN mk677 mk 677 Ibutamoren,whnohe_lucy(at)163.com MK677,Mk677 MK-677 Selective Androgen Receptor Modulators SARMs Bodybuilding CAS 159752-10-0 (R)-1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(Methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] Mesylate Crescendo IbutaMoren Mesylate(MK-677) N-[1(R)-1,2-Dihydro-1-methanesulfonylspiro-3H-indole-3,4′-piperidin)-1′-yl]carbonyl-2-(phenylmethoxy)-ethyl-2-amino-2-methylpropanamide methanesulfonate IBUTAMORIN Ibutamoren, MK-0677 (R)-2-Amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]-1'-yl)-1-oxo 2-Amino-N-[2-benzyloxy-(1R)-[1-(methanesulfonyl)spiro[indoline-3,4'-piperidin]-1'-ylcarbonyl]ethyl]isobutyramide methanesulfonate MK677(mesylate salt) Ibutamoren 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide,methanesulfonic acid MK-677 MK-677 White powder 99% China MK-677 mk 677 mk677 CAS 159752-10-0 supplier CAS NO. 159752-10-0 SARMs MK-677 Fat Burning Steroids CAS 159752-10-0 Ibutamoren For Muscle Gain MK-677,mk677,mk 677 MK677 MK-677 mk677 Sarms powder CAS NO.159752-10-0 MK-677(L163191,Ibutamoren) Ibutamoren mesylate, >=98% Ibutamoren mesilate sarms mk 677 / mk677 ibutamoren MK677/MK-677/Ibutamoren Mesylate Ibutamoren Mesylate/MK677/MK-677 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-pip Ibutamoren mesylate (MK-677) sarms Ibutamoren Sarms 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide,methanesulfonicaci Ibuprofen mesylate (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide methanesulfonate MK-677 USP/EP/BP Pharmaceutical Grade MK677 Ibmoren mesylate High quality MK 677 sarms MK677 powder Propanamide, 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-, methanesulfonate (1:1) 2-Amino-N-[2-benzyloxy-(1R)-[1-(methanesulfonyl)spiro[indoli... MK677 (MK6, Nutrobal)-1 gram(31) MK677 Synonyms: Ibutamoren Mesylate CHEMBL13817 MK 0677 Ibutamoren mesylate nutrobal MK-677，Ibutamoren Mesylate， nutrobal MK677 Ibutamoren mesilate MK 0677,MK 677,Inhibitor,Ibutamoren,MK677,inhibit,Ibutamoren Mesylate,Growth hormone secretagogue receptor,GHSR,MK0677 Ibumolan mesylate MK-0667 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4&apos -piperidine]-1&apos -yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide Ibutamoren Mesylate, 10 mM in DMSO MK 677 25mg MK-677/159752-10-0/98% MK-667