ChemicalBook >> CAS DataBase List >>(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid structure

CAS No.: 230961-21-4

Chemical Name:: (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid

Synonyms: UK 370106;UK 370106,UK370106;(R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylaMino)-3,3-diMethyl-1-o;(R)-3-(((S)-1-(((S)-2-Methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-m;(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid;(3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid;(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoicacid;[1,1'-Biphenyl]-4-hexanoic acid, β-[[[(1S)-1-[[[(1S)-2-methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-, (βR)-

CBNumber:: CB42514857

Molecular Formula:: C35H44N2O5

Molecular Weight:: 572.73

MDL Number:: MFCD12828744

MOL File:: 230961-21-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-29 13:23:30

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(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid Properties

Melting point	178-180 °C
Boiling point	802.7±65.0 °C(Predicted)
Density	1.122±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	<57.27mg/ml in DMSO; <14.32mg/ml in ethanol
form	solid
pka	4.68±0.10(Predicted)
color	White

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	257020	UK 370106 Asreported	230961-21-4	10mg	$516	2026-06-03	Buy
Biosynth	FJA96121	UK 370106	230961-21-4	50mg	$3710	2026-06-04	Buy
ChemScene	CS-0029038	UK-370106 96.70%	230961-21-4	1mg	$173	2026-06-04	Buy
ChemScene	CS-0029038	UK-370106 96.70%	230961-21-4	5mg	$509	2026-06-04	Buy
ChemScene	CS-0029038	UK-370106 96.70%	230961-21-4	10mg	$867	2026-06-04	Buy

Product number	Packaging	Price	Buy
257020	10mg	$516	Buy
FJA96121	50mg	$3710	Buy
CS-0029038	1mg	$173	Buy
CS-0029038	5mg	$509	Buy
CS-0029038	10mg	$867	Buy

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid Chemical Properties, Uses, Production

Uses

UK 370106 is a selective, insoluble MMP-3 inhibitor used for the topical treatment of chronic dermal ulcers and wound healing wafers.

Biological Activity

(mmp-3)stromelysin-1 also known as matrix metalloproteinase-3 (mmp-3) is an enzyme that in humans is encoded by the mmp3 gene. proteins of the matrix metalloproteinase (mmp) family are involved in the breakdown of extracellular matrix and during tissue remodeling in normal physiological processes, such as embryonic development and reproduction, as well as in disease processes, such as arthritis, and tumour metastasis.

in vitro

uk-370106, a potent inhibitor of mmp-3 (ic50 ) 23 nm) with >1200-fold weaker potency vs mmp-1, -2, -9, and -14. mmp-13, may contribute to the pathology of chronic wounds. uk-370106 potently inhibited cleavage of [3h]-fibronectin by mmp-3 (ic50 ) 320 nm) but not cleavage of [3h]-gelatin by either mmp-2 or -9 (up to 100 ím). uk-370106 had little effect, at mmp-3 selective concentrations, on keratinocyte migration over a collagen matrix in vitro, which is a model of the re-epithelialization process [1].

in vivo

following iv (rat) or topical administration to dermal wounds (rabbit), uk-370106 was cleared rapidly (t1/2=23 min) from plasma, but slowly (t1/2 ~ 3 days) from dermal tissue. in a model of chronic dermal ulcers, topical administration of uk-370106 for 6 days substantially inhibited mmp-3 ex vivo. these data suggest uk-370106 is sufficiently potent to inhibit mmp-3-mediated matrix degradation while leaving unaffected cellular migration mediated by mmps 1, 2, and 9.

IC 50

23 nm

storage

Store at -20°C

References

[1] fray mj, dickinson rp, huggins jp, occleston nl. a potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. j med chem. 2003;46(16):3514-25.
[2] whitlock ga, dack kn, dickinson rp, lewis ml. a novel series of highly selective inhibitors of mmp-3. bioorg med chem lett. 2007;17(24):6750-3.

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid Suppliers

Global Suppliers ( 39)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ChemCell Biomedicine Co.,Ltd.	020-13556033878 2965585218 13556033878	chemcell@hotmail.com	China	369	52
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7717	56
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19904	58
Energy Chemical	400-0056266	marketing1@energy-chemical.com	China	44927	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8137	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ChemCell Biomedicine Co.,Ltd.	52
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
EMMX Biotechnology LLC	60
TargetMol Chemicals Inc.	58
Nextpeptide Inc	58
Energy Chemical	58
MedBioPharmaceutical Technology Inc	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58

View Latest Price from (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-29	(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid 230961-21-4		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-07-27	UK-370106 230961-21-4	$1120.00			10g	TargetMol Chemicals Inc.
2025-07-18	UK-370106 230961-21-4				10g	TargetMol Chemicals Inc.

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
230961-21-4
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

UK-370106
230961-21-4
$1120.00
TargetMol Chemicals Inc.

UK-370106
230961-21-4
$0.00
TargetMol Chemicals Inc.

230961-21-4 ((R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid) Related Search:

Sulfanilamide methyl (2S,5S,8S,11S)-8-benzyl-2-isobutyl-11-isopropyl-5-methyl-3,6,9,12,17-pentaoxo-1,4,7,10,13-pentaazacycloheptadecane-14-carboxylate (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid DC-Y13-27 ADAM8 Protein, MOUSE (HEK293, HIS)

MMP-9 Protein, RAT (HEK293, HIS)

1of2

(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoicacid UK 370106 (R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylaMino)-3,3-diMethyl-1-o (R)-3-(((S)-1-(((S)-2-Methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-m (3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid [1,1'-Biphenyl]-4-hexanoic acid, β-[[[(1S)-1-[[[(1S)-2-methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-, (βR)- UK 370106,UK370106 230961-21-4 C35H44N2O5