1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- CAS No.
- 1206640-82-5
- Chemical Name:
- 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Synonyms
- 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(Difluoromethyl)pyrazole-4-boronic aci;1-(Difluoromethyl)pyrazole-4-boronic acid pinacol ester;1-(Difluoromethyl)-1H-pyrazole-4-boronic acid pinacol ester;1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan;(1-(DIFLUOROMETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;1-(difluoroMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-y;1-(difluoromethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1H-Pyrazole, 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB42514877
- Molecular Formula:
- C10H15BF2N2O2
- Molecular Weight:
- 244.05
- MDL Number:
- MFCD17011852
- MOL File:
- 1206640-82-5.mol
- MSDS File:
- SDS
| Boiling point | 294.9±40.0 °C(Predicted) |
|---|---|
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | -1.01±0.19(Predicted) |
| form | solid |
| color | White |
| InChI | InChI=1S/C10H15BF2N2O2/c1-9(2)10(3,4)17-11(16-9)7-5-14-15(6-7)8(12)13/h5-6,8H,1-4H3 |
| InChIKey | SACVSUQLLHEZLY-UHFFFAOYSA-N |
| SMILES | N1(C(F)F)C=C(B2OC(C)(C)C(C)(C)O2)C=N1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933199090 |
1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FD105889 | 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan | 1206640-82-5 | 500mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD105889 | 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan | 1206640-82-5 | 5000mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD105889 | 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan | 1206640-82-5 | 2000mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD105889 | 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan | 1206640-82-5 | 1000mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD105889 | 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan | 1206640-82-5 | 10000mg | $900 | 2026-06-04 | Buy |
1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties, Uses, Production
Synthesis
269410-08-4
1895-39-2
1206640-82-5
Step 1: Synthesis of 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole To a 100 mL round bottom flask was added 4-pyrazole boronic acid pinacol ester (1.0 g, 5.15 mmol), 18-crown-6 (0.27 g, 1.03 mmol) and anhydrous acetonitrile (25 mL). The mixture was stirred until a colorless homogeneous solution was formed and then sodium difluorochloroacetate (0.94 g, 6.18 mmol) was added. The reaction mixture was heated to reflux and held for 18 hours. After completion of the reaction, the mixture was cooled to room temperature. Insoluble solids were removed by filtration through a diatomaceous earth pad and the filter cake was washed with ethyl acetate (3 x 20 mL). The filtrate and washings were combined, filtered through a hydrophobic glassine and concentrated under reduced pressure to give a light yellow oily crude product. The crude product was purified by fast silica gel column chromatography (gradient elution, hexane to 33% ethyl acetate/isohexane) to afford 1-(difluoromethyl)-4-boronic acid pinacol ester-based-1H-pyrazole as a colorless solid (1.06 g, 84% yield). The mass spectrum (electrospray positive ion mode) showed the molecular ion peak (M+H)+ consistent with the target compound.
References
[1] Patent: WO2014/159218, 2014, A1. Location in patent: Paragraph 00218
[2] Patent: WO2014/159224, 2014, A1. Location in patent: Paragraph 00256
[3] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0324; 0325
[4] Patent: US2010/197651, 2010, A1. Location in patent: Page/Page column 84
[5] Patent: WO2014/1377, 2014, A1. Location in patent: Page/Page column 119; 120
1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rong Lin Medical Technology Co., Ltd. | 18602194589 | lincy-110@163.com | China | 873 | 58 |
| Nanjing xiangrui technology co. LTD | 021-021-00000000 15715199582 | njrich168@163.com | China | 501 | 58 |
| Shandong Xuande Pharmaceutical Technology Co. LTD | 18866895588 | dingjiaying@shiningpharm.com | China | 184 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
View Latest Price from 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1206640-82-5
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1206640-82-5
- $1.00
- 95%
- Career Henan Chemical Co
