Sodium chlorodifluoroacetate
- CAS No.
- 1895-39-2
- Chemical Name:
- Sodium chlorodifluoroacetate
- Synonyms
- Sodium 2-chloro-2,2-difluoroacetate;2-chloro-2,2-difluoroacetate;SodiuM Difluorochloroacetate;CHLORODIFLUOROACETIC ACID SODIUM SALT;DIFLUOROCHLOROACETIC ACID SODIUM SALT;orodifL;Sodiumchlorodifluoride;Sodiumdifluorochlorate;Roflumilast impurity 24;SODIUM CHLORODIFLUOROACETATE
- CBNumber:
- CB3135211
- Molecular Formula:
- C2HClF2O2.Na
- Molecular Weight:
- 153.47
- MDL Number:
- MFCD00064771
- MOL File:
- 1895-39-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 196-198 °C (lit.) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in dimethoxyethane, diglyme (0.60 g mL-1), triglyme, dimethyl formamide. |
| form | Powder |
| color | White to off-white |
| BRN | 4162363 |
| InChI | InChI=1S/C2HClF2O2.Na.H/c3-2(4,5)1(6)7;;/h(H,6,7);; |
| InChIKey | MRTAVLDNYYEJHK-UHFFFAOYSA-M |
| SMILES | C(F)(F)(Cl)C(=O)O.[NaH] |
| CAS DataBase Reference | 1895-39-2(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, chlorodifluoro-, sodium salt (1895-39-2) |
| UNSPSC Code | 12352302 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT, HYGROSCOPIC | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Sodium chlorodifluoroacetate price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 374067 | Sodium chlorodifluoroacetate 96% | 1895-39-2 | 25g | $96.7 | 2026-04-30 | Buy |
| TCI Chemical | C0991 | Sodium Chlorodifluoroacetate >99.0%(T) | 1895-39-2 | 25g | $29 | 2026-04-30 | Buy |
| TCI Chemical | C0991 | Sodium Chlorodifluoroacetate >99.0%(T) | 1895-39-2 | 100g | $82 | 2026-04-30 | Buy |
| Usbiological | 289074 | Sodium chlorodifluoroacetate Asreported | 1895-39-2 | 50g | $333 | 2026-06-03 | Buy |
| Usbiological | 289074 | Sodium chlorodifluoroacetate Asreported | 1895-39-2 | 100g | $460 | 2026-06-03 | Buy |
Sodium chlorodifluoroacetate Chemical Properties, Uses, Production
Chemical Properties
white to off-white powder
Uses
It is used as pharmaceutical intermediate. Reactions of aldehydes with triphenylphosphine and sodium chlorodifluoroacetate yield 1,1-difluoro olefins. It is a general reaction and a one step synthesis.
Application
Sodium chlorodifluoroacetate is used for generation of difluorocarbene and the synthesis of difluorocyclopropanes and difluoroalkenes.
Preparation
Sodium chlorodifluoroacetate is prepared by careful neutralization of 130.5 g (1.0 mol) of chlorodifluoroacetic acid in 300 mL of Et2O with 53 g (0.5 mol) of anhydrous Na2CO3. The Et2O and water are removed under reduced pressure. The salt is then dried in a vacuum desiccator over P2O5. [1]
storage
Sodium chlorodifluoroacetate is an irritant and is hygroscopic.
References
1. Herkes, F. E.; Burton, D. J. OSC 1973, 5, 949
Sodium chlorodifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhongshan Dixin Chemical Co., Ltd | 15327055492 15327055492 | 2470479589@qq.com | China | 1747 | 58 |
| Ji'nan Langhua Chemical Co. Ltd. | 0531-85906691 18660816586 | 325912680@qq.com | China | 100 | 50 |
| HuBei ZhuoXi Fluorochemical Co., Ltd., | 0712-3586991 13801737011;13361903612 | xxg@hbzxchem.com | China | 9 | 58 |
| Shanghai Furui Fine Chemicals Co., Ltd. | 021-36041048 13361903612 | 13361903612@189.cn | China | 12 | 55 |
| chengqiaotech.ltd | 0533-2196219; 13864320634 | lijindu01@163.com | China | 197 | 58 |
| Fuxin Kaituo Fine Chemical Technology Co., Ltd | 15714082442 | 3757845877@qq.com | China | 343 | 58 |
| SHANG FLUORO | 021-65170832 15601903708 | qinba_1@163.com | China | 401 | 60 |
| Jinan Wanxingda New Material Technology Co., Ltd. | 0531-88064106 18253116016 | zhangjia@wxdchem.com | China | 44 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
View Latest Price from Sodium chlorodifluoroacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Sodium chlorodifluoroacetate
1895-39-2
|
$75.00-750.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-03-20 | Sodium chlorodifluoroacetate
1895-39-2
|
$9.90 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | Sodium chlorodifluoroacetate
1895-39-2
|
1kg | 99%min | 100 tons | Hangzhou Verychem Science And Technology Co.Ltd |
-
- Sodium chlorodifluoroacetate
1895-39-2
- $75.00-750.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Sodium chlorodifluoroacetate
1895-39-2
- $9.90
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Sodium chlorodifluoroacetate
1895-39-2
- 99%min
- Hangzhou Verychem Science And Technology Co.Ltd
