ChemicalBook >> CAS DataBase List >>7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester structure

CAS No.: 161157-50-2

Chemical Name:: 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester

Synonyms: 1-Boc-3,4-epoxypiperidine;N-BOC-3,4-epoxypiperidine;tert-butyl (1RS,6SR)-7-ox...;7-Oxa-3-azabicyclo[4.1.0]heptan;N-Boc-7-oxa-3-azabicyclo[4.1.0]heptane;1-tert-Butoxycarbonyl-3,4-epoxypiperidine;Tert-butyl 7-oxa-3-azabicyclo[4.1.]heptane-3-carboxylate;tert-butyl 7-oxa-4-azabicyclo[4.1.0]heptane-4-carboxylate;tert-Butyl 7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate;7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dime...

CBNumber:: CB42525211

Molecular Formula:: C10H17NO3

Molecular Weight:: 199.25

MDL Number:: MFCD12407050

MOL File:: 161157-50-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:23:14

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7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester Properties

Boiling point	272.5±23.0 °C(Predicted)
Density	1.141±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-0.83±0.20(Predicted)
form	clear liquid
color	Colorless to Light orange to Yellow
InChI	InChI=1S/C10H17NO3/c1-10(2,3)14-9(12)11-5-4-7-8(6-11)13-7/h7-8H,4-6H2,1-3H3
InChIKey	MMPWHAJQEZIIEH-UHFFFAOYSA-N
SMILES	C12C(O1)CCN(C(OC(C)(C)C)=O)C2
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

WGK Germany

WGK 3

HS Code

2918300090

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5969	tert-Butyl 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate	161157-50-2	1G	$53	2026-04-30	Buy
TCI Chemical	B5969	tert-Butyl 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate	161157-50-2	5G	$179	2026-04-30	Buy
Apolloscientific	OR308133	tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate >98%	161157-50-2	250mg	$21	2026-06-04	Buy
Apolloscientific	OR308133	tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate >98%	161157-50-2	1g	$24	2026-06-04	Buy
Apolloscientific	OR308133	tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate >98%	161157-50-2	5g	$29	2026-06-04	Buy

Product number	Packaging	Price	Buy
B5969	1G	$53	Buy
B5969	5G	$179	Buy
OR308133	250mg	$21	Buy
OR308133	1g	$24	Buy
OR308133	5g	$29	Buy

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester Chemical Properties, Uses, Production

Synthesis

85838-94-4

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester

161157-50-2

The general procedure for the synthesis of tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate from N-Boc-1,2,3,6-tetrahydropyridine was carried out as follows: tert-butyl 5,6-dihydropyridine-1(2H)-carboxylate (2.00 g, 10.9 mmol) was dissolved in dichloromethane (DCM) as described in the literature WO 97/10212 and added with m-chloroperoxybenzoic acid (MCPBA, 4.16 g, 18.6 mmol). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was washed sequentially with saturated aqueous sodium metabisulfite solution, saturated aqueous sodium bicarbonate solution, 1N aqueous sodium hydroxide solution and saturated brine. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (2.04 g, 94% yield) as an oil. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shift δ of 1.45 (s, 9H), 1.91 (m, 1H), 2.04 (br, 1H), 3.11 (m, 1H), 3.21 (br, 1H), 3.29 (m, 1H), 3.45 (br, 1H), 3.70 (br, 1H), 3.88 (br 1H).

References

[1] Tetrahedron Letters, 2004, vol. 45, # 37, p. 6841 - 6845
[2] Organic Process Research and Development, 2014, vol. 18, # 2, p. 321 - 330
[3] Patent: WO2008/11130, 2008, A2. Location in patent: Page/Page column 136-137
[4] Patent: WO2013/138210, 2013, A1. Location in patent: Paragraph 0243
[5] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 39 - 52

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

N-Boc-3,4-dihydro-2H-pyridine N-Boc-1,2,3,6-tetrahydropyridine 3-Chloroperoxybenzoic acid Dichloromethane

Preparation Products

N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester Suppliers

Global Suppliers ( 109)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai AQBioPharma Co., Ltd.	13661411401	yinglv.que@aqbiopharma.com.cn	China	2976	58
Doly Chemical CO.,LTD.	021-34716221 15800796336	sales@dolypharm.com	China	294	55
Shanghai AQ BioPharma Co., Ltd.	13512160998; 13512160998	sales@aqbiopharma.com.cn	China	3007	58
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Nan Jing Dirise Chemcial Co.,LTD	025-52161033 15312098939	2432674894@qq.com	China	585	64
Tongchuang Pharma(Suzhou). Co., Ltd.	0512-63263366 18912765016	tongtf110@sina.com	China	984	62

Supplier	Advantage
Shanghai AQBioPharma Co., Ltd.	58
Doly Chemical CO.,LTD.	55
Shanghai AQ BioPharma Co., Ltd.	58
Shanghai Hobor Chemical Co., Ltd	60
Shanghai Boyle Chemical Co., Ltd.	55
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64
Nan Jing Dirise Chemcial Co.,LTD	64
Tongchuang Pharma(Suzhou). Co., Ltd.	62

View Latest Price from 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-17	1-Boc-3,4-epoxypiperidine 161157-50-2		100g	97%	500kg/M	Changsha YuTeng New Materials Co., Ltd.
	2019-07-06	tert-Butyl 7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate 161157-50-2	$500.00	1KG	98%	10tons	Career Henan Chemical Co

1-Boc-3,4-epoxypiperidine
161157-50-2
97%
Changsha YuTeng New Materials Co., Ltd.

tert-Butyl 7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate
161157-50-2
$500.00
98%
Career Henan Chemical Co

7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester Spectrum

tert-butyl (1RS,6SR)-7-ox...(161157-50-2)¹HNMR

161157-50-2 (7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethyl ester) Related Search:

tert-butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate Tert-Butyl 7-Oxo-5-Azaspiro[2.4]Heptane-5-Carboxylate Tert-Butyl7-oxo-3-azabicyclo[3.3.1]nonane-3-carboxylate tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate tert-Butyl 8-oxa-2-azaspiro[4.5]decane-2-carboxylate

tert-butyl 7-oxo-4-azaspiro[2.5]octane-4-carboxylate tert-Butyl 7-oxo-2-azaspiro[3.5]nonane-2-carboxylate tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate

1of2

tert-Butyl 7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-diMethylethyl ester tert-butyl (1RS,6SR)-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate Tert-butyl 7-oxa-3-azabicyclo[4.1.]heptane-3-carboxylate 1,1-Dimethylethyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 1-tert-Butoxycarbonyl-3,4-epoxypiperidine 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid tert-butyl ester N-BOC-3,4-epoxypiperidine 7-Oxa-3-azabicyclo[4.1.0]heptan N-Boc-7-oxa-3-azabicyclo[4.1.0]heptane tert-butyl 7-oxa-4-azabicyclo[4.1.0]heptane-4-carboxylate 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dime... tert-butyl (1RS,6SR)-7-ox... tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 1-Boc-3,4-epoxypiperidine 161157-50-2