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tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate structure

CAS No.: 637301-19-0

Chemical Name:: tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate

Synonyms: 3-Boc-8-oxo-3-Azabicyclo[...;3-Boc-3-azabicyclo[3.2.1]octan-8-one;3-Boc-8-oxo-3-Azabicyclo[3.2.1]octane;tert-Butyl 8-oxo-3-azabicyclo[3.2.1]octan-3-carboxylate;tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate;1,1-Dimethylethyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate;8-Oxo-3-aza-bicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester;3-Azabicyclo[3.2.1]octane-3-carboxylic acid, 8-oxo-, 1,1-dimethylethyl ester

CBNumber:: CB52537482

Molecular Formula:: C12H19NO3

Molecular Weight:: 225.28

MDL Number:: MFCD21642031

MOL File:: 637301-19-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
tert-Butyl8-Oxo-3-azabicyclo[3.2.1]octane-3-carboxylate	B815088	10mg	$45
3-Boc-8-oxo-3-azabicyclo[3.2.1]octane	FB57605	10mg	$65
3-Boc-8-oxo-3-azabicyclo[3.2.1]octane	FB57605	25mg	$125
3-Boc-8-oxo-3-azabicyclo[3.2.1]octane	4H56-1-022	250mg	$175
tert-Butyl8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate 95%	OR301348	250mg	$195
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tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate Properties

Boiling point	325.8±35.0 °C(Predicted)
Density	1.139±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	-1.58±0.20(Predicted)
Appearance	White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code	2933998090

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B815088	tert-Butyl8-Oxo-3-azabicyclo[3.2.1]octane-3-carboxylate	637301-19-0	10mg	$45	2021-12-16	Buy
Biosynth Carbosynth	FB57605	3-Boc-8-oxo-3-azabicyclo[3.2.1]octane	637301-19-0	10mg	$65	2021-12-16	Buy
Biosynth Carbosynth	FB57605	3-Boc-8-oxo-3-azabicyclo[3.2.1]octane	637301-19-0	25mg	$125	2021-12-16	Buy
SynQuest Laboratories	4H56-1-022	3-Boc-8-oxo-3-azabicyclo[3.2.1]octane	637301-19-0	250mg	$175	2021-12-16	Buy
Apolloscientific	OR301348	tert-Butyl8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate 95%	637301-19-0	250mg	$195	2021-12-16	Buy

Product number	Packaging	Price	Buy
B815088	10mg	$45	Buy
FB57605	10mg	$65	Buy
FB57605	25mg	$125	Buy
4H56-1-022	250mg	$175	Buy
OR301348	250mg	$195	Buy

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate Chemical Properties,Uses,Production

Uses

Tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceuticals and bioactive compounds. Its unique structure and reactivity allow for the development of new drug candidates with potential therapeutic applications.

Synthesis

24424-99-5

83507-33-9

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate

637301-19-0

Di-tert-butyl dicarbonate (5.81 g, 26.6 mmol) and 3-benzyl-3-azabicyclo[3.2.1]octan-8-one (5.0 g, 22.0 mmol) were used as raw materials in ethyl acetate (74 mL) with Pearlman's catalyst (1.55 g, 23.2 mmol). The reaction system was stirred overnight at 25 °C under 100 psi hydrogen pressure after passing through three nitrogen substitutions and two hydrogen substitutions. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with ethyl acetate. The filtrate was concentrated and purified by silica gel column chromatography (elution gradient: heptane/ethyl acetate, 0:100 to 100:0) to afford 3-Boc-3-azabicyclo[3.2.1]octan-8-one (4.49 g, 90% yield) as a solid. The product was analyzed by LC/MS showing [M-Me] = 211.1; 1H NMR (400 MHz, CDCl3) δ 4.38 (d, J = 14.0 Hz, 1H), 4.20 (d, J = 14.0 Hz, 1H), 3.27 (d, J = 13.3 Hz, 1H), 3.17 (d, J = 13.3 Hz, 1H), 2.24 ( d, J = 15.6 Hz, 2H), 1.76-1.99 (m, 4H), 1.49 (s, 9H).

References

[1] Patent: WO2016/120849, 2016, A1. Location in patent: Page/Page column 63
[2] Patent: WO2012/169649, 2012, A1. Location in patent: Page/Page column 207; 208

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate synthesis

Synthesis of tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate from Di-tert-butyl dicarbonate and 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate Preparation Products And Raw materials

Raw materials

3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE Di-tert-butyl dicarbonate Cyclopentanone Ethyl acetate Hydrogen

Preparation Products

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5899	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58

Supplier	Advantage
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
CR Corporation Limited	58
Labnetwork lnc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Golden Pharma Co., Limited	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58

View Lastest Price from tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-08	tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate 637301-19-0	US $3.00 / KG	1KG	99%min	300kg	Career Henan Chemical Co

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate
637301-19-0
US $3.00 / KG
99%min
Career Henan Chemical Co

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate Spectrum

tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate(637301-19-0)¹HNMR

637301-19-0(tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate)Related Search:

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tert-butyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate 3-Boc-8-oxo-3-Azabicyclo[3.2.1]octane 3-Boc-8-oxo-3-Azabicyclo[... 3-Boc-3-azabicyclo[3.2.1]octan-8-one 8-Oxo-3-aza-bicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester 3-Azabicyclo[3.2.1]octane-3-carboxylic acid, 8-oxo-, 1,1-dimethylethyl ester 1,1-Dimethylethyl 8-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate tert-Butyl 8-oxo-3-azabicyclo[3.2.1]octan-3-carboxylate 637301-19-0