(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid
![(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid Structure](CAS/GIF/49855-91-6.gif)
- CAS No.
- 49855-91-6
- Chemical Name:
- (2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid
- Synonyms
- (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid;Z-Dab(Boc);Z-L-DAB(BOC)-OH;N-Cbz-N'-Boc-L-2,4-Diaminobutyric acid;N-α-Z-N-γ-Boc-L-2,4-diaminobutyric acid;(S)-2-(Cbz-amino)-4-(Boc-amino)butanoic Acid;(S)-4-(Boc-amino)-2-(Cbz-amino)butanoic acid;N-α-Carbobenzoxy-N-γ-(t-butoxycarbonyl)-L-α,γ-diaminobutyric acid;(S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid - [B91580];(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid
- CBNumber:
- CB42534565
- Molecular Formula:
- C17H24N2O6
- Molecular Weight:
- 352.38
- MDL Number:
- MOL File:
- 49855-91-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | B91580 | (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid 97% | 49855-91-6 | 1g | $125 | 2026-05-06 | Buy |
| Synthonix | B91580 | (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid 97% | 49855-91-6 | 5g | $140 | 2026-05-06 | Buy |
| Synthonix | B91580 | (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid 97% | 49855-91-6 | 10g | $290 | 2026-05-06 | Buy |
| Synthonix | B91580 | (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid 97% | 49855-91-6 | 25g | $480 | 2026-05-06 | Buy |
| Synthonix | B91580 | (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid 97% | 49855-91-6 | 100g | $960 | 2026-05-06 | Buy |
(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid Chemical Properties, Uses, Production
Synthesis
24424-99-5
62234-40-6
![(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid](/CAS/GIF/49855-91-6.gif)
49855-91-6
GENERAL STEPS: Sodium bicarbonate (3.13 g, 37.3 mmol) was added to a mixed solution of (S)-4-amino-2-(((benzyloxy)carbonyl)amino)butanoic acid (4.70 g, 18.6 mmol) in tetrahydrofuran (50 mL) and water (50 mL). The reaction mixture was stirred at room temperature for 5 minutes, followed by slow dropwise addition of a solution of di-tert-butyl dicarbonate (4.88 g, 22.4 mmol) in tetrahydrofuran (50 mL) over 10 minutes. The reaction mixture was continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, most of the tetrahydrofuran was removed by vacuum concentration. The residual aqueous solution was acidified to pH 2 by dropwise addition of aqueous 2 M hydrochloric acid and subsequently extracted with ethyl acetate (100 mL, then 50 mL). The combined organic phases were washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the target product (S)-2-(((benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid as a colorless oil (6.65 g, 98% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6) and LC/MS (System A): 1H NMR δ 12.60 (s, 1H), 7.57 (d, J = 8.0 Hz, 1H), 7.41-7.24 (m, 5H), 6.87-6.76 (m, 1H), 5.03 (s, 2H), 4.00-3.92 (m, 1H), 3.06-2.90 (m, 2H), 1.92-1.77 (m, 1H), 1.71-1.59 (m, 1H), 1.37 (s, 9H); LC/MS m/z (ESI+) = 375 [M + Na+], Rt = 1.06 min, UV purity = 97%.
References
[1] Patent: WO2018/96325, 2018, A1. Location in patent: Page/Page column 157-158
[2] Patent: WO2009/18549, 2009, A1. Location in patent: Page/Page column 58
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 2, p. 305 - 308
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 10, p. 3150 - 3154
(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(2S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
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