AMG-208
- CAS No.
- 1002304-34-8
- Chemical Name:
- AMG-208
- Synonyms
- CS-191;AMG-208;AMG-208, >=98%;AMG208; AMG 208;AMG-208 USP/EP/BP;AMG-208;AMG208; AMG 208;7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline;Quinoline, 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)Methoxy]-;7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline AMG 208
- CBNumber:
- CB42561457
- Molecular Formula:
- C22H17N5O2
- Molecular Weight:
- 383.4
- MDL Number:
- MFCD17215205
- MOL File:
- 1002304-34-8.mol
| Density | 1.34 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥3.83 mg/mL in DMSO |
| form | solid |
| pka | 5.98±0.27(Predicted) |
| color | White to off-white |
| FDA UNII | Y2SR66P7VM |
AMG-208 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24197 | AMG 208 ≥98% | 1002304-34-8 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 24197 | AMG 208 ≥98% | 1002304-34-8 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 24197 | AMG 208 ≥98% | 1002304-34-8 | 10mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 24197 | AMG 208 ≥98% | 1002304-34-8 | 25mg | $751 | 2024-03-01 | Buy |
| TRC | A576533 | amg208 | 1002304-34-8 | 5mg | $330 | 2021-12-16 | Buy |
AMG-208 Chemical Properties,Uses,Production
Uses
AMG-208 is an orally active c-Met/RON dual selective inhibitor with an IC50 of 9 nM for c-Met. AMG-208 is a CYP3A4 inhibitor with an IC50 of 32 μM. AMG-208 has anti-cancer activity[1][2][3].
Definition
ChEBI: A member of the class of quinolines that is 7-methoxyquinoline substituted at position 4 by a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group. AMG exhibits antitumour activity, particularly in prostate cancer.
in vivo
In male Sprague Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour[1].
target
Met
IC 50
CYP3A4: 32 μM (IC50); c-Met: 9 nM (IC50)
References
[1] Albrecht BK, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008, 51(10), 2879-2882. DOI:10.1021/jm800043g
[2] Boezio AA, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009, 19(22), 6307-6312. DOI:10.1016/j.bmcl.2009.09.096
[3] Liu X, et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010,16(1), 37-45. DOI:10.1016/j.molmed.2009.11.005
AMG-208 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22866 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
