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PD 0332991 HCl

PD 0332991 HCl Structure
PD 0332991 HCl structure
CAS No.
827022-32-2
Chemical Name:
PD 0332991 HCl
Synonyms
Palbociclib HCl;CS-365;PD 0332991 HCl;Palbociclib-025;Palbociclib-019-HCl;PD 0332991;PD-0332991;StemSelect PD 0332991;PD 0332991 hydrochloride;PD-0332991 (Palbociclib);PD 0332991 HCl USP/EP/BP
CBNumber:
CB22593007
Molecular Formula:
C24H30ClN7O2
Molecular Weight:
484
MDL Number:
MFCD22420809
MOL File:
827022-32-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-09 13:54:35
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PD 0332991 HCl Properties

storage temp. = -70C
solubility ≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form Yellow liquid
color Light yellow to yellow
Water Solubility water: 10mg/mL
InChIKey STEQOHNDWONVIF-UHFFFAOYSA-N
SMILES O=C1C(=C(C)C2=CN=C(NC3N=CC(N4CCNCC4)=CC=3)N=C2N1C1CCCC1)C(=O)C.Cl
FDA UNII BKC4F3Q5XL
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany  WGK 3
HS Code  29399990
Storage Class 11 - Combustible Solids

PD 0332991 HCl price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.30487 StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem 827022-32-2 5mg $156 2026-04-30 Buy
Cayman Chemical 16273 PD 0332991 (hydrochloride) ≥95% 827022-32-2 1mg $41 2026-04-30 Buy
Cayman Chemical 16273 PD 0332991 (hydrochloride) ≥95% 827022-32-2 5mg $119 2026-04-30 Buy
Cayman Chemical 16273 PD 0332991 (hydrochloride) ≥95% 827022-32-2 10mg $215 2026-04-30 Buy
Cayman Chemical 16273 PD 0332991 (hydrochloride) ≥95% 827022-32-2 25mg $389 2026-04-30 Buy
Product number Packaging Price Buy
5.30487 5mg $156 Buy
16273 1mg $41 Buy
16273 5mg $119 Buy
16273 10mg $215 Buy
16273 25mg $389 Buy

PD 0332991 HCl Chemical Properties, Uses, Production

Description

PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.

Uses

PD 0332991 is an orally active, selective CDK4/6 inhibitor that blocks pRb phosphorylation at serine 780 and 795 in the low nanomolar range and is in clinical development for the treatment of solid tumors[3][4].

General Description

A cell-permeable, orally available and brain permeant, non-toxic pyridopyrimidinone compound that acts as a potent, selective, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC50 = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk6/D2, respectively). Hence, it reduces retinoblastoma protein phosphorylation at Ser780/Ser795 (IC50 = 66 nM in MDA-435 cells) and arrests cell cycle at G1 phase. Acts as a cytostatic agent, but does induce apoptotic cell death when used alone. However, it potentiates the cytotoxicity of dexamethasone (>Cat. No. 265005), bortezomib (>Cat. No. 504314), and tamoxifen (Cat. No. 579000) in estrogen receptor (ER)-positive cell lines. Exhibits only a trivial inhibitory activity towards Cdk2/E2, Cdk2/A, Cdk1/B and Cdk5/p25 in a 36-kinase panel (IC50 >10 μM). Improves endoderm differentiation of late G1-human embryonic stem cells expressing Smad2 or Smad3 (~ 750 nM) and further enhances endoderm differentiation into hepatic and pancreatic progenitor cells. Shown to regress the growth of human breast tumor xenografts in murine models (~150 mg/kg, p.o., daily).

Biochem/physiol Actions

Cell permeable: yes

Synthesis

4-{6-[8-CYCLOPENTYL-6-(1-ETHOXY-VINYL)-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO]-PYRIDIN-3-YL}-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

571189-10-1

PD 0332991 HCl

827022-32-2

Synthesis of 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride from tert-butyl 4-[6-[[8-cyclopentyl-6-(1-ethoxyethenyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-carboxylate. [2,3-d]pyrimidin-7(8H)-one hydrochloride was prepared in the following general procedure: to tert-butyl 4-[6-[[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-D]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carboxylate under ice-bath cooling conditions (4.50 g. 0.00783 mol, as prepared in Example 2) in a solution of dichloromethane (100 mL) was bubbled with hydrogen chloride gas. The resulting suspension was sealed and stirred overnight at room temperature and subsequently diluted with ether (200 mL). The solid was collected by filtration, washed with ether and dried to afford 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride as a yellow solid (4.01 g, 92% yield).

target

CDK4/cyclin D1

References

[1] ivan diaz-padilla, lillian l. siu and ignacio duran. cyclin-dependent kinase inhibitors as potential targeted anticancer agents. invest new drugs. 2009, 27: 586–594.
[2] richard s finn, judy dering, dylan conklin, ondrej kalous, david j cohen, amrita j desai, charles ginther, mohammad atefi, isan chen, camilla fowst, gerret los and dennis j slamon. pd 0332991, a selective cyclin d kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. breast cancer research. 2009, 11: r77.
[3]Nguyen, L., Zhong, W.-Z., Painter, C. L., Zhang, C., Rahavendran, S. V., & Shen, Z. (2010). Quantitative analysis of PD 0332991 in xenograft mouse tumor tissue by a 96-well supported liquid extraction format and liquid chromatography/mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 53(3), 228–234. https://doi.org/10.1016/j.jpba.2010.02.031
[4]Nemoto, A., Saida, S., Kato, I., Kikuchi, J., Furukawa, Y., Maeda, Y., Akahane, K., Honna-Oshiro, H., Goi, K., Kagami, K., Kimura, S., Sato, Y., Okabe, S., Niwa, A., Watanabe, K., Nakahata, T., Heike, T., Sugita, K., & Inukai, T. (2016). Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia. Molecular Cancer Therapeutics, 15(1), 94–105. https://doi.org/10.1158/1535-7163.mct-14-1065

PD 0332991 HCl synthesis

571189-10-1
827022-32-2
Synthesis of PD 0332991 HCl from 4-{6-[8-Cyclopentyl-6-(1-ethoxy-vinyl)-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl}-piperazine-1-carboxylic acid tert-butyl ester

PD 0332991 HCl Preparation Products And Raw materials

Raw materials

Palbociclib 4-{6-[8-Cyclopentyl-6-(1-ethoxy-vinyl)-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl}-piperazine-1-carboxylic acid tert-butyl ester Hydrochloric acid Dichloromethane

Preparation Products

PD 0332991 HCl Suppliers

Global Suppliers ( 243)
Supplier Tel Email Country ProdList Advantage
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101 1276242629@qq.com China 9977 58
Taizhou Tongxin Bio-Tech Co., Ltd 0523-86818997 18652728585 sales@allyrise.com China 2986 60
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Supplier Advantage
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. 58
Taizhou Tongxin Bio-Tech Co., Ltd 60
Shanghai Boyle Chemical Co., Ltd. 55
Nanbu County Chengxin Technology Co., Ltd. 55
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Jinan Trio PharmaTech Co., Ltd. 62
Shanghai civi chemical technology co.,Ltd 52

View Latest Price from PD 0332991 HCl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PD 0332991 HCl pictures 2026-09-02 PD 0332991 HCl
827022-32-2
 $1.20-31.00 1kg 99% Henan Fengda Chemical Co., Ltd
PD 0332991 HCl USP/EP/BP pictures 2026-08-20 PD 0332991 HCl USP/EP/BP
827022-32-2
 $1.10 1g 99.9% 100 Tons min Dideu Industries Group Limited
PD 0332991 HCl pictures 2026-07-03 PD 0332991 HCl
827022-32-2
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
  • PD 0332991 HCl pictures
  • PD 0332991 HCl
    827022-32-2
  • $1.20-31.00
  • 99%
  • Henan Fengda Chemical Co., Ltd

PD 0332991 HCl Spectrum

PD 0332991 HCl(827022-32-2)1HNMR

827022-32-2 (PD 0332991 HCl) Related Search:

PD0332991 Isethionate 6-acetyl-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride
4-[[(4-Fluorophenyl)imino]methyl]-phenol Flupirtine maleate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
Palbociclib 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one MK-2206 2HCl Ribociclib Trametinib
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol tert-Butyl 4-(6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido(2,3-d)pyrimidin-2-ylamino)-pyridin-3-yl)-piperazine-1-carboxylate (4S)-3-[(5R)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

1of4

PD 0332991 HCl PALBOCICLIB HCL; PD0332991 HCL 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride Palbociclib (PD-0332991) HCl Palbociclib hydrochloride, >=98% PD-0332991 (Palbociclib) PD 0332991 hydrochloride Palbociclib (hydrochloride) Palbociclib (PD-0332991) HCl 6-acetyl-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one hydrochloride 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride PD 0332991 HCl (Palbociclib) Palbociclib-025 PD 0332991 (Palbociclib) HCl CS-365 Palbociclib-019-HCl PD 0332991;PD-0332991 Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-,monohydrochloride Palbociclib (PD-0332991) hydrochloride 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one hydrochloride 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin- Palbociclib hydrochloride, 99%, a highly selective CDK4/6 inhibitor PALBOCICLIB;PD-0332991 HYDROCHLORIDE;PD0332991 HYDROCHLORIDE;PD 0332991 HYDROCHLORIDE Palbociclib, brand name: Ibrance PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; PALBOCICLIB, BRAND NAME: IBRANCE PD 0332991 HCl USP/EP/BP Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-me... Palbociclib (monohydrochloride) TIANFU-CHEM CAS:827022-32-2 PD 0332991 HCl 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride1 PALBOCICLIB (PD-0332991) (HCL SALT) Palbociclib Impurity 22 HCl Palbociclib Impurity 20 HCl PD 0332991 hydrochloride(1:1) StemSelect PD 0332991 PD-0332991 HCl (Palbociclib HCl) Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8- cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2- pyridinyl]amino]-, hydrochloride (1:1) Palbociclib hydrochloride (PD-0332991 hydrochloride 6-ethylacyl-8-cyclopentyl-5-methyl-2-[[5-(azine-1-yl)pyridine-2-yl]amino]-8H-pyridinebenzo[2,3-d]pyrimidine-7-onehydrochloride Palbociclib HCl 827022-32-2 C24H29N7O2HCl C24H30ClN7O2 C24H29N7O2ClH Inhibitors