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BS-181 hydrochloride

BS-181 hydrochloride Structure
BS-181 hydrochloride structure
CAS No.
1092443-52-1
Chemical Name:
BS-181 hydrochloride
Synonyms
BS 181;CS-507;CS-2137;BS-181 HCl;BS-181 free base;BS-181 hydrochloride;N5-(6-Aminohexyl)-3-isopropyl-N7-benzylpyrazolo[1,5-a]pyrimidine-5,7-diamine;Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-;5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride
CBNumber:
CB42561462
Molecular Formula:
C22H32N6
Molecular Weight:
380.53
MDL Number:
MFCD22056527
MOL File:
1092443-52-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:42
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BS-181 hydrochloride Properties

Density 1.16
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 10.62±0.10(Predicted)
color White to off-white
FDA UNII 75M620LLBN

BS-181 hydrochloride price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17996 BS-181 ≥98% 1092443-52-1 1mg $35 2021-12-16 Buy
Cayman Chemical 17996 BS-181 ≥98% 1092443-52-1 5mg $158 2021-12-16 Buy
Biosynth STB44352 BS-181 1092443-52-1 25mg $801.75 2026-06-05 Buy
Biosynth STB44352 BS-181 1092443-52-1 50mg $1282.5 2026-06-05 Buy
Biosynth STB44352 BS-181 1092443-52-1 100mg $1785 2026-06-05 Buy
Product number Packaging Price Buy
17996 1mg $35 Buy
17996 5mg $158 Buy
STB44352 25mg $801.75 Buy
STB44352 50mg $1282.5 Buy
STB44352 100mg $1785 Buy

BS-181 hydrochloride Chemical Properties,Uses,Production

Uses

BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].

Definition

ChEBI: N5-(6-aminohexyl)-N7-(phenylmethyl)-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine is a pyrazolopyrimidine.

in vivo

BS-181 (intraperitoneal injection; 5 mg/kg or 10 mg/kg twice daily; total daily doses of 10 mg/kg or 20 mg/kg; 14 days) inhibitstumor growth in a dose-dependent manner.Tumor growth exhibits 25% and 50% reduction compared with the control group, for 10 mg/kg/day and 20 mg/kg/day, respectively[1].

Animal Model:7-week old female nu/nu-BALB/c athymic nude micewith MCF-7 cells[1]
Dosage:5 mg/kg or 10 mg/kg; 10 mg/kg or 20 mg/kg
Administration:Intraperitoneal injection; twice daily or once total daily; 14 days
Result:Inhibited tumor growth significantly.

IC 50

CDK7/CycH/MAT1: 0.021 μM (IC50); CDK2/Cyc E: 0.88 μM (IC50); CDK5/p35NCK: 3 μM (IC50); CDK9/cycT: 4.2 μM (IC50); CDK1/cycB: 8.1 μM (IC50); CDK4/Cyc D1: 33 μM (IC50); CDK6/cycD1: 47 μM (IC50)

References

[1] Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15. DOI:10.1158/0008-5472.CAN-09-0301
[2] Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9. DOI:10.2147/DDDT.S86317

BS-181 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

BS-181 hydrochloride Suppliers

Global( 110)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
Zhengzhou Saifun Biotechnology Co., Ltd. 022-60688926 China 60 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Shanghai civi chemical technology co.,Ltd 52
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
AdooQ BioScience, LLC 58
AdooQ Bioscience CHINA 60
Shanghaizehan biopharma technology co., Ltd. 55
Zhengzhou Saifun Biotechnology Co., Ltd. 55

View Lastest Price from BS-181 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BS-181 hydrochloride pictures 2019-12-31 BS-181 hydrochloride
1092443-52-1
 $1.00 1KG Min98% HPLC Career Henan Chemical Co

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BS-181 free base CS-2137 CS-507 5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride BS-181 hydrochloride BS 181 N5-(6-Aminohexyl)-3-isopropyl-N7-benzylpyrazolo[1,5-a]pyrimidine-5,7-diamine BS-181 HCl Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)- 1092443-52-1 Inhibitors