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2,5-Dichloroquinoline

2,5-Dichloroquinoline Structure
2,5-Dichloroquinoline structure
CAS No.
59412-12-3
Chemical Name:
2,5-Dichloroquinoline
Synonyms
2,5-DICHLOROQUINOLINE;DICHLOROQUINOLINE(2,5-);Quinoline, 2,5-dichloro-;2,5-Dichloroquinoline,95%,QC-6736
CBNumber:
CB4257989
Molecular Formula:
C9H5Cl2N
Molecular Weight:
198.05
MDL Number:
MFCD00832074
MOL File:
59412-12-3.mol
MSDS File:
SDS
Last updated:2026-05-28 03:05:30
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2,5-Dichloroquinoline Properties

Melting point 76-77 °C(Solv: hexane (110-54-3))
Boiling point 304.0±22.0 °C(Predicted)
Density 1.407±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.77±0.50(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933499090

2,5-Dichloroquinoline price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth JCA41212 2,5-Dichloroquinoline 59412-12-3 10g $472 2026-06-04 Buy
Activate Scientific AS42273 2,5-Dichloroquinoline 95% 59412-12-3 1g $69 2026-06-04 Buy
Activate Scientific AS42273 2,5-Dichloroquinoline 95% 59412-12-3 5g $104 2026-06-04 Buy
Matrix Scientific 121342 2,5-Dichloro-quinoline 59412-12-3 1.00g $800 2026-05-18 Buy
A1 Biochem Labs A1-00342 2,5-Dichloro-quinoline 0.95 59412-12-3 1g $500 2026-06-05 Buy
Product number Packaging Price Buy
JCA41212 10g $472 Buy
AS42273 1g $69 Buy
AS42273 5g $104 Buy
121342 1.00g $800 Buy
A1-00342 1g $500 Buy

2,5-Dichloroquinoline Chemical Properties, Uses, Production

Uses

2,5-Dichloroquinoline can be used as a pharmaceutical synthesis intermediate.

Synthesis

5-chloroquinoline 1-oxide

90224-97-8

2,5-Dichloroquinoline

59412-12-3

Step 2: Preparation of 5-chloro-2-chloroquinoline (compound 181-3) To a solution of 5-chloroquinoline azide (compound 181-2, 19 g, 106 mmol) in dichloromethane (DCM, 250 mL) was added phosphorus oxychloride (POCl3, 32 g, 212 mmol). The reaction mixture was heated to 40°C and stirred for 1.5 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate (NaHCO3) solution (500 mL) was slowly added and the mixture was stirred at 15°C for 10 minutes. Subsequently, the aqueous phase was extracted with ethyl acetate (300 mL x 3). The organic phases were combined, washed with brine (500 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum. The residue was purified by column chromatography (silica gel 100-200 mesh, column height: 250 mm, diameter: 100 mm, eluent: petroleum ether/ethyl acetate=50/1~20/1) to afford 5-chloro-2-chloroquinoline (Compound 181-3, 9.8 g, 40% yield) as a white solid.

References

[1] Patent: WO2016/54491, 2016, A1. Location in patent: Paragraph 00625
[2] Bioorganic and medicinal chemistry, 2002, vol. 10, # 8, p. 2611 - 2623
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1472 - 1476

2,5-Dichloroquinoline Preparation Products And Raw materials

Raw materials

5-chloroquinoline 1-oxide Dichloromethane trichlorophosphate

Preparation Products

2,5-Dichloroquinoline Suppliers

Global Suppliers ( 85)
Supplier Tel Email Country ProdList Advantage
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Goodee Pharma Co., Ltd. 0512-62956210 yongyan@goodeepharma.com China 132 60
Chimica Laboratories Co., Ltd 0086-573-82585213 bai@chimicalabs.com China 861 64
Shanghai XIYU Chemical Technology Co.,Ltd. 021-15000143735 15221126179 sala@xiyuchem.com China 375 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4875 55
Nanjing ERan Biological Pharmaceutical Co., Ltd. 13770809694 googlexu_0114@sina.com China 992 58
Jiaxing Rich Biological Technology Co., Ltd. 0573-11111111-1111 18969316891 richmol@163.com China 446 50
Supplier Advantage
Daicel Chiral Technologies (China)CO.,LTD 65
Goodee Pharma Co., Ltd. 60
Chimica Laboratories Co., Ltd 64
Shanghai XIYU Chemical Technology Co.,Ltd. 55
Bide Pharmatech Ltd. 60
Shanghai Worldyang Chemical Co.,Ltd. 58
Cool Pharm, Ltd 58
AN PharmaTech Co Ltd 55
Nanjing ERan Biological Pharmaceutical Co., Ltd. 58
Jiaxing Rich Biological Technology Co., Ltd. 50

View Latest Price from 2,5-Dichloroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DICHLOROQUINOLINE(2,5-) pictures 2025-12-24 DICHLOROQUINOLINE(2,5-)
59412-12-3
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2,5-Dichloroquinoline pictures 2020-02-26 2,5-Dichloroquinoline
59412-12-3
 $1.00 1KG 99%+ 100 tons Shaanxi Dideu Medichem Co. Ltd
2,5-Dichloroquinoline pictures 2020-02-26 2,5-Dichloroquinoline
59412-12-3
 1KG 99.0%+ 100 tons Shaanxi Dideu Medichem Co. Ltd

2,5-Dichloroquinoline Spectrum

2,5-Dichloroquinoline(59412-12-3)1HNMR

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DICHLOROQUINOLINE(2,5-) Quinoline, 2,5-dichloro- 2,5-DICHLOROQUINOLINE 2,5-Dichloroquinoline,95%,QC-6736 59412-12-3