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2-chloro-5-hydroxyisonicotinaldehyde

2-chloro-5-hydroxyisonicotinaldehyde Structure
2-chloro-5-hydroxyisonicotinaldehyde structure
CAS No.
1060804-53-6
Chemical Name:
2-chloro-5-hydroxyisonicotinaldehyde
Synonyms
2-chloro-5-hydroxyisonicotinaldehyde;2-CHLORO-5-HYDROXYPYRIDINE-4-CARBALDEHYDE;4-Pyridinecarboxaldehyde, 2-chloro-5-hydroxy-;2-chloro-5-hydroxyisonicotinaldehyde ISO 9001：2015 REACH
CBNumber:
CB42582935
Molecular Formula:
C6H4ClNO2
Molecular Weight:
157.55
MDL Number:
MFCD13189121
MOL File:
1060804-53-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:43
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2-chloro-5-hydroxyisonicotinaldehyde Properties

Boiling point 353.3±37.0 °C(Predicted)
Density 1.504±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 6.71±0.10(Predicted)
Appearance Yellow to brown Solid

SAFETY

Risk and Safety Statements

HS Code  2933399990

2-chloro-5-hydroxyisonicotinaldehyde price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth KSB80453 2-Chloro-5-hydroxyisonicotinaldehyde 1060804-53-6 250mg $332.5 2026-06-04 Buy
Biosynth KSB80453 2-Chloro-5-hydroxyisonicotinaldehyde 1060804-53-6 2.5g $1504.5 2026-06-04 Buy
Apolloscientific OR939481 2-Chloro-5-hydroxyisonicotinaldehyde 98% 1060804-53-6 100mg $93 2026-06-04 Buy
Apolloscientific OR939481 2-Chloro-5-hydroxyisonicotinaldehyde 98% 1060804-53-6 250mg $109 2026-06-04 Buy
Activate Scientific AS42443 2-Chloro-5-hydroxyisonicotinaldehyde 95% 1060804-53-6 250mg $247 2026-06-04 Buy
Product number Packaging Price Buy
KSB80453 250mg $332.5 Buy
KSB80453 2.5g $1504.5 Buy
OR939481 100mg $93 Buy
OR939481 250mg $109 Buy
AS42443 250mg $247 Buy

2-chloro-5-hydroxyisonicotinaldehyde Chemical Properties, Uses, Production

Synthesis

2-chloro-5-(MethoxyMethoxy)isonicotinaldehyde

1282516-32-8

2-chloro-5-hydroxyisonicotinaldehyde

1060804-53-6

2-Chloro-5-(methoxymethoxy)pyridine-4-carboxaldehyde (12 g, 59.52 mmol, 1.00 eq.) was used as a starting material, which was dissolved in tetrahydrofuran (80 mL) and 3M hydrochloric acid (130 mL) was added. The reaction mixture was stirred at 60°C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with 5% aqueous sodium carbonate to 7. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (400 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography, the eluent was ethyl acetate/petroleum ether (1:3), to obtain 2-chloro-5-hydroxypyridine-4-carbaldehyde (6g, yield 64%) as a light yellow solid. the TLC detection conditions: petroleum ether/ethyl acetate = 2:1, Rf = 0.3.

References

[1] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 95; 96
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 18, p. 8345 - 8368

2-chloro-5-hydroxyisonicotinaldehyde synthesis

1282516-32-8
1060804-53-6
Synthesis of 2-chloro-5-hydroxyisonicotinaldehyde from 2-chloro-5-(MethoxyMethoxy)isonicotinaldehyde

2-chloro-5-hydroxyisonicotinaldehyde Preparation Products And Raw materials

Raw materials

2-chloro-5-(MethoxyMethoxy)isonicotinaldehyde Hydrochloric acid Tetrahydrofuran Water

Preparation Products

2-chloro-5-hydroxyisonicotinaldehyde Suppliers

Global Suppliers ( 58)
Supplier Tel Email Country ProdList Advantage
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Hebei Summedchem Co.,Ltd 0319-5801333-8008 15630992918 sales@summedchem.com China 1000 58
Shanghai Hong-chuang Pharma Tech Co., Ltd. 18151128828 hc-sales@foxmail.com China 2635 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Changzhou Hopschain Chemical Co.,Ltd. 85528066 13775048983 sales@hopschem.com China 31548 55
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Supplier Advantage
Acorn PharmaTech Co., Ltd. 60
Hebei Summedchem Co.,Ltd 58
Shanghai Hong-chuang Pharma Tech Co., Ltd. 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Changzhou Hopschain Chemical Co.,Ltd. 55
Shanghai SuperLan Chemcial Technique Centre 58
Amadis Chemical Company Limited 58
Wuxi AppTec 58
Capot Chemical Co.,Ltd. 60

View Latest Price from 2-chloro-5-hydroxyisonicotinaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-chloro-5-hydroxyisonicotinaldehyde pictures 2026-08-20 2-chloro-5-hydroxyisonicotinaldehyde
1060804-53-6
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-chloro-5-hydroxyisonicotinaldehyde pictures 2019-12-20 2-chloro-5-hydroxyisonicotinaldehyde
1060804-53-6
 1g 95%min 20kg/month Nanjing jinheyou Trading Co., Ltd.

2-chloro-5-hydroxyisonicotinaldehyde Spectrum

2-chloro-5-hydroxyisonicotinaldehyde(1060804-53-6)1HNMR2-chloro-5-hydroxyisonicotinaldehyde(1060804-53-6)13CNMR
2-chloro-5-hydroxyisonicotinaldehyde 2-CHLORO-5-HYDROXYPYRIDINE-4-CARBALDEHYDE 4-Pyridinecarboxaldehyde, 2-chloro-5-hydroxy- 2-chloro-5-hydroxyisonicotinaldehyde ISO 9001：2015 REACH 1060804-53-6