1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl-
- CAS No.
- 1254319-51-1
- Chemical Name:
- 1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl-
- Synonyms
- 6-broMo-2-Methyl-2,3-dihydro-1H-isoindol-1-one;6-bromo-2-methyl-3H-isoindol-1-one;6-Bromo-2-methyl-2,3-dihydro-isoindol-1-one;6-Bromo-2,3-dihydro-2-methyl-1H-isoindol-1-one;1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl-
- CBNumber:
- CB42597731
- Molecular Formula:
- C9H8BrNO
- Molecular Weight:
- 226.07
- MDL Number:
- MFCD17676936
- MOL File:
- 1254319-51-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P260-P271-P280 |
| HS Code | 2933998090 |
1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl- price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR306541 | 6-Bromo-2-methylisoindolin-1-one >99% | 1254319-51-1 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR306541 | 6-Bromo-2-methylisoindolin-1-one >99% | 1254319-51-1 | 250mg | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR306541 | 6-Bromo-2-methylisoindolin-1-one >99% | 1254319-51-1 | 1g | $67 | 2026-06-04 | Buy |
| Apolloscientific | OR306541 | 6-Bromo-2-methylisoindolin-1-one >99% | 1254319-51-1 | 5g | $308 | 2026-06-04 | Buy |
| Apolloscientific | OR306541 | 6-Bromo-2-methylisoindolin-1-one >99% | 1254319-51-1 | 25g | $1449 | 2026-06-04 | Buy |
1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl- Chemical Properties, Uses, Production
Synthesis
675109-26-9
74-88-4
1254319-51-1
GENERAL METHODS: 6-Bromoisoindolin-1-one (2.0 g, 9.43 mmol) was dissolved in N,N-dimethylformamide (DMF, 150 mL) under heating conditions and subsequently cooled to 0°C. The reaction was carried out under nitrogen protection by slowly adding sodium hydride (NaH, 415 mg, 10.4 mmol) to the reaction system. Sodium hydride (NaH, 415 mg, 10.4 mmol) was slowly added to the reaction system under nitrogen protection and the reaction mixture was stirred at 0 °C for 30 min. Subsequently, iodomethane (0.65 mL, 10.4 mmol) was added dropwise and the reaction system was gradually warmed up to room temperature with continued stirring for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of a small amount of water, followed by evaporation of DMF under reduced pressure to give a yellow oily residue. The residue was dissolved in ethyl acetate (EtOAc, 150 mL), washed sequentially with water (3 x 100 mL), saturated saline (100 mL) and dried with anhydrous sodium sulfate (Na2SO4). The organic solvent was removed by concentration under reduced pressure to obtain the crude product, which was purified by silica gel column chromatography (eluent: 10% acetone/dichloromethane). N-methyl-6-bromoisoindolin-1-one was finally obtained as a very light yellow crystalline solid (1.64 g, 80% yield).1H NMR (400 MHz, (CD3)2SO) δ: 7.85 (dd, J = 1.5, 0.6 Hz, 1H), 7.66 (dd, J = 8.0, 1.7 Hz, 1H), 7.59 (d, J = 8.0 Hz , 1H), 4.46 (s, 2H), 3.05 (s, 3H).LRMS (APCI) Calculated C9H8BrNO2 [M+H]+: 226, 228, Measured: 226, 228.
References
[1] Patent: WO2014/28968, 2014, A1. Location in patent: Page/Page column 64; 107
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9542 - 9555
[3] E-Journal of Chemistry, 2011, vol. 8, # 3, p. 1108 - 1113
1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl- Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Shanghai SunSyn Pharmaceutical Co., Ltd. | 021-18621020637 18621020637 | sales@sunsynpharma.com | China | 297 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | 1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl-
1254319-51-1
|
$1.00 | 1g | 99.0% | 100 kg | Career Henan Chemical Co |
-
- 1H-Isoindol-1-one, 6-broMo-2,3-dihydro-2-Methyl-
1254319-51-1
- $1.00
- 99.0%
- Career Henan Chemical Co
