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5-bromo-2-methylisoindolin-1-one

5-bromo-2-methylisoindolin-1-one Structure
5-bromo-2-methylisoindolin-1-one structure
CAS No.
868066-91-5
Chemical Name:
5-bromo-2-methylisoindolin-1-one
Synonyms
5-bromo-2-methylisoindolin-1-on;5-bromo-2-methylisoindolin-1-one;5-bromo-2-methyl-3h-isoindol-1-one;5-Bromo-2-methyl-2,3-dihydroisoindol-1-one;5-broMo-2-Methyl-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 5-bromo-2,3-dihydro-2-methyl-
CBNumber:
CB42470489
Molecular Formula:
C9H8BrNO
Molecular Weight:
226.07
MDL Number:
MFCD12755780
MOL File:
868066-91-5.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:53
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5-bromo-2-methylisoindolin-1-one Properties

Boiling point 356.2±42.0 °C(Predicted)
Density 1.589
storage temp. Sealed in dry,Room Temperature
pka -1.60±0.20(Predicted)
Appearance Off-white to light brown Solid

SAFETY

Risk and Safety Statements

HS Code  2933998090

5-bromo-2-methylisoindolin-1-one price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR306525 5-Bromo-2-methylisoindolin-1-one 97% 868066-91-5 250mg $21 2026-06-04 Buy
Apolloscientific OR306525 5-Bromo-2-methylisoindolin-1-one 97% 868066-91-5 1g $22 2026-06-04 Buy
Apolloscientific OR306525 5-Bromo-2-methylisoindolin-1-one 97% 868066-91-5 5g $92 2026-06-04 Buy
Apolloscientific OR306525 5-Bromo-2-methylisoindolin-1-one 97% 868066-91-5 25g $361 2026-06-04 Buy
Apolloscientific OR306525 5-Bromo-2-methylisoindolin-1-one 97% 868066-91-5 100g $1335 2026-06-04 Buy
Product number Packaging Price Buy
OR306525 250mg $21 Buy
OR306525 1g $22 Buy
OR306525 5g $92 Buy
OR306525 25g $361 Buy
OR306525 100g $1335 Buy

5-bromo-2-methylisoindolin-1-one Chemical Properties, Uses, Production

Synthesis

Methylamine

74-89-5

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

78471-43-9

5-bromo-2-methylisoindolin-1-one

868066-91-5

The general procedure for the synthesis of 5-bromo-2-methylisodihydroindol-1-one from methyl 4-bromo-2-(bromomethyl)benzoate (1.2 g, 3.0 mmol) and methylamine (2.0 M THF solution, 10 mL, 20 mmol) is as follows: 1. add a THF solution of methyl 4-bromo-2-(bromomethyl)benzoate and methylamine to the reaction tube. 2. the reaction tube was sealed, the mixture was stirred and heated at 50 °C overnight. 3. Upon completion of the reaction, the mixture was cooled to room temperature. 4. The reaction mixture was filtered and the precipitate was washed with THF. 5. The filtrate was concentrated under vacuum to give the crude product. 6. The crude product was purified by column chromatography using 0-100% ethyl acetate/heptane as eluent to afford 5-bromo-2-methylisodihydroindol-1-one (623 mg, 2.75 mmol, 71% yield) as a white solid. The product characterization data are as follows: 1H NMR (CDCl3, 400MHz) δ/ppm: 7.73-7.68 (1H, m), 7.64-7.56 (2H, m), 4.36 (2H, s), 3.19 (3H, s). MS Method 3: RT: 3.18min, m/z 226.0/228.0 [M + H]+.

References

[1] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00527; 00530; 00531
[2] Patent: US10112955, 2018, B2. Location in patent: Page/Page column 29
[3] Patent: WO2013/148603, 2013, A1. Location in patent: Paragraph 0233-0234
[4] Patent: EP3406612, 2018, A1. Location in patent: Paragraph 0086; 0087

5-bromo-2-methylisoindolin-1-one Preparation Products And Raw materials

Raw materials

Benzamide, 4-bromo-2-(hydroxymethyl)-N-methyl- 5-Bromo-2,3-dihydro-isoindol-1-one Methylamine Methyl 4-bromo-2-bromomethyl-benzoate Iodomethane

Preparation Products

5-bromo-2-methylisoindolin-1-one Suppliers

Global Suppliers ( 94)
Supplier Tel Email Country ProdList Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Candia Thamtech Company Limited 0371-86615086 18203638366 0371-86159066 13526786601 China 2011 60
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4905 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 02161555100 China 820 58
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Supplier Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Shanghai Topbiochem Technology Co., Ltd 58
Candia Thamtech Company Limited 60
Shanghai Raise Chemical Technology Co.,Ltd 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Bide Pharmatech Ltd. 60
ShangHai KenEn Chemical Technology Co., Ltd. 55
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 58
Hangzhou J&H Chemical Co., Ltd. 59
Cool Pharm, Ltd 58

View Latest Price from 5-bromo-2-methylisoindolin-1-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-bromo-2-methylisoindolin-1-one pictures 2020-01-13 5-bromo-2-methylisoindolin-1-one
868066-91-5
 $1.00 1KG 98%-99.9% 100kg Career Henan Chemical Co

5-bromo-2-methylisoindolin-1-one Spectrum

5-bromo-2-methylisoindolin-1-one(868066-91-5)1HNMR

868066-91-5 (5-bromo-2-methylisoindolin-1-one) Related Search:

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5-bromo-2-methylisoindolin-1-one 5-broMo-2-Methyl-2,3-dihydro-1H-isoindol-1-one 5-Bromo-2-methyl-2,3-dihydroisoindol-1-one 5-bromo-2-methylisoindolin-1-on 5-bromo-2-methyl-3h-isoindol-1-one 1H-Isoindol-1-one, 5-bromo-2,3-dihydro-2-methyl- 868066-91-5