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ChemicalBook >> CAS DataBase List >>2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Structure
2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride structure
CAS No.
199864-86-3
Chemical Name:
2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
Synonyms
MT 500 Hydrochloride;RS 127445 hydrochloride NEW;RS-127445 hydrochloride, 10 mM in DMSO;4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine;2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride;2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride;4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride;2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
CBNumber:
CB42609717
Molecular Formula:
C17H17ClFN3
Molecular Weight:
317.7883832
MDL Number:
MFCD11112196
MOL File:
199864-86-3.mol
MSDS File:
SDS
Last updated:2025-05-06 17:57:48
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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Properties

Melting point 158 °C
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
color white to tan
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933.59.5300
NFPA 704
0
2 0

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R2533 RS-127445 hydrochloride ≥98% (HPLC), powder 199864-86-3 5mg $129 2024-03-01 Buy
Sigma-Aldrich R2533 RS-127445 hydrochloride ≥98% (HPLC), powder 199864-86-3 25mg $500 2024-03-01 Buy
TCI Chemical R0221 RS-127445 Hydrochloride 199864-86-3 10MG $211 2024-03-01 Buy
TCI Chemical R0221 RS-127445 Hydrochloride 199864-86-3 50MG $756 2024-03-01 Buy
Cayman Chemical 23451 RS 127445 (hydrochloride) ≥98% 199864-86-3 1 mg $32 2024-03-01 Buy
Product number Packaging Price Buy
R2533 5mg $129 Buy
R2533 25mg $500 Buy
R0221 10MG $211 Buy
R0221 50MG $756 Buy
23451 1 mg $32 Buy

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Chemical Properties,Uses,Production

Uses

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Biological Activity

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

in vivo

In rats, the fraction of RS-127445 that is bioavailable via the oral or intraperitoneal routes is 14 and 60% respectively. Intraperitoneal administration of RS-127445 (5 mg/kg) produced plasma concentrations predicted to fully saturate accessible 5-HT2B receptors for at least 4 h.RS-127445 (5 mg/kg) is administered to rats by oral, intraperitoneal and intravenous routes. Peak plasma concentrations are rapidly achieved with the highest concentrations being found at the first time-point measured following intravenous and intraperitonael administration (0.08 h) and by 0.25 h following dosing by the oral route of administration. RS-127445 is cleared from plasma with an estimated terminal elimination half-life of approximately 1.7 h. The bioavailability of RS-127445, when administered by the oral and intraperitoneal routes is approximately 14 and 62% of that obtained by intravenous administration. Approximately 60% of an intraperitoneal dose and 14% of the oral dose of RS-127445 (5 mg/kg) is bioavailable[1]. RS-127445 (1-30 mg/kg), dose-dependently reduces faecal output, reaching significance at 10 and 30 mg/kg (n=6-11). In blood and brain, >98% of RS-127445 is protein-bound[2].

IC 50

sPLA2: 5.5 (pKi); 5-HT3 Receptor: <6 (pKi); 5-HT5 Receptor: <6 (pKi); 5-HT6 Receptor: <6 (pKi); 5-HT2A Receptor: 6.3 (pKi); 5-HT2C Receptor: 6.4 (pKi); 5-HT2B Receptor: 9.5 (pKi)

storage

Desiccate at +4°C

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Suppliers

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9297 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jk.info@jkchemical.com China 96815 76
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Henan Aochuang Chemical Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76

View Lastest Price from 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RS-127445 hydrochloride pictures 2025-05-06 RS-127445 hydrochloride
199864-86-3
 US $30.00-85.00 / mg 99.48% 10g TargetMol Chemicals Inc.
RS 127445 hydrochloride pictures 2025-04-04 RS 127445 hydrochloride
199864-86-3
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Spectrum

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride(199864-86-3)1HNMR

199864-86-3(2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride)Related Search:

Methylcyclohexane Ethyl nonafluorobutyl ether 2-Methyl-4-isothiazolin-3-one 2-(Perfluorohexyl)ethyl methacrylate
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride 2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride MT 500 Hydrochloride 4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride RS 127445 hydrochloride NEW RS-127445 hydrochloride, 10 mM in DMSO 199864-86-3 17H16FN3HCl