ChemicalBook >> CAS DataBase List >>7,10-Dimethoxy-10-DAB III
7,10-Dimethoxy-10-DAB III
- CAS No.
- 183133-94-0
- Chemical Name:
- 7,10-Dimethoxy-10-DAB III
- Synonyms
- 12a;Cabazitaxel Impurity;11S;12S;(2aR;4]benz[1;11-dihydroxy-4;6-dimethoxy-4a;7,10-MeO-10-DAB;13-tetramethyl-7
- CBNumber:
- CB42630016
- Molecular Formula:
- C31H40O10
- Molecular Weight:
- 572.64
- MDL Number:
- MFCD23100710
- MOL File:
- 183133-94-0.mol
- MSDS File:
- SDS
Last updated:2025-07-16 09:56:26
| Product description | Number | Pack Size | Price |
| 4-Deacetyl-4-propionyl Cabazitaxel | 432029 | 1mg | $523 |
| 4-Deacetyl-4-propionyl Cabazitaxel | 432029 | 10mg | $2796 |
| 10-Deacetyl-7,10-dimethoxy-Baccatin III Asreported | 411612 | 50mg | $468 |
| 10-Deacetyl-7,10-dimethoxy-Baccatin III Asreported | 411612 | 100mg | $871 |
| 10-Deacetyl-7,10-dimethoxy-Baccatin III | TRC-D198890-50MG | 50mg | $233 |
| More product size | |||
| Melting point | >225°C (dec.) |
|---|---|
| Boiling point | 675.8±55.0 °C(Predicted) |
| Density | 1.31 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF (Slightly, Heated, Sonicated), DMSO (Very Slightly, Heated), Methanol |
| form | Solid |
| pka | 12.82±0.70(Predicted) |
| color | White to Off-White |
| optical activity | -27.00°(C=0.01g/mL, DMF, 589nm) |
| Stability | Hygroscopic |
| InChIKey | MGJMLMORVVDLIU-VHLOTGQHSA-N |
| SMILES | O1C[C@@]2(OC(C)=O)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](O)C4)[C@@H](OC)C(=O)[C@]3(C)[C@@H](OC)C[C@@]12[H] |
7,10-Dimethoxy-10-DAB III price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 432029 | 4-Deacetyl-4-propionyl Cabazitaxel | 1mg | $523 | 2026-06-03 | Buy | |
| Usbiological | 432029 | 4-Deacetyl-4-propionyl Cabazitaxel | 10mg | $2796 | 2026-06-03 | Buy | |
| Usbiological | 411612 | 10-Deacetyl-7,10-dimethoxy-Baccatin III Asreported | 183133-94-0 | 50mg | $468 | 2026-06-03 | Buy |
| Usbiological | 411612 | 10-Deacetyl-7,10-dimethoxy-Baccatin III Asreported | 183133-94-0 | 100mg | $871 | 2026-06-03 | Buy |
| TRC | TRC-D198890-50MG | 10-Deacetyl-7,10-dimethoxy-Baccatin III | 183133-94-0 | 50mg | $233 | 2026-06-03 | Buy |
7,10-Dimethoxy-10-DAB III Chemical Properties,Uses,Production
Description
Cabazitaxel is a kind of Second line Drug for the treatment of prostate cancer, FDA Priority Review status approval listing is obtained because its curative effect is remarkable, for the advanced prostate cancer patients to the invalid even aggravation of Docetaxel, the first-selected medicine being used for the treatment of late period, hormone antagonist type prostate cancer.7,10-dimethoxy-10-Dab III is the important intermediate preparing Cabazitaxel.
Uses
4-Deacetyl-4-propionyl Cabazitaxel is an impurity of Cabazitaxel (C046500).A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
Synthesis
Solvent is methylene dichloride, and alkali is the two dimethylamino naphthalene of 1,8-, and the mol ratio of 10-deacetylate Bakating III and trimethylammonium oxygen Tetrafluoroboric acid is 1:35; The mol ratio of 10-deacetylate Bakating III and alkali is 1:45;By 10-Dab (10g, 18.4mmol) be dissolved in methylene dichloride (200ml), add 1, the two dimethylamino naphthalene (177.2g of 8-, 828mmol), stirring at room temperature half an hour, add trimethylammonium oxygen Tetrafluoroboric acid (95.2g, 643.4mmol) again, stirring at room temperature 20h, suction filtration reaction solution, filter cake methylene dichloride washes 3 times, collects filtrate, and after concentrated, column chromatography (chloroform: methyl alcohol=100:3) obtains 7,10-dimethoxy-10Dab III 4.6g, yield 43.7%.
7,10-Dimethoxy-10-DAB III Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 198)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9666 | 58 |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29094 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15050 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9035 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhuoer Chemical Co., Ltd | 02120970332; | sales@zhuoerchem.com | China | 2901 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
View Lastest Price from 7,10-Dimethoxy-10-DAB III manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-25 | 7,10-Dimethoxy-10-DAB III
183133-94-0
|
$80.00 | 1KG | 99% | 10Tons | Hebei Senko Biotechnology Co., Ltd. | |
 |
2021-07-13 | 7.10-Dimethoxy-10-DAB III
183133-94-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-09 | 7.10-Dimethoxy-10-DAB III
183133-94-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 7,10-Dimethoxy-10-DAB III
183133-94-0
- $80.00
- 99%
- Hebei Senko Biotechnology Co., Ltd.
-
- 7.10-Dimethoxy-10-DAB III
183133-94-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 7.10-Dimethoxy-10-DAB III
183133-94-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
183133-94-0(7,10-Dimethoxy-10-DAB III)Related Search:
Dapoxetine
7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III
(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid
"7-(triMethylsilyl)-13-O-[((4S,5R)-2,4-diphenyl-4,5-dihydro oxazol-5-yl)carbonyl]baccatin Ⅲ
7-Troc-paclitaxel
Cabazitaxel N-3
7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III
2',3'-O,N-[(S)-(p-Methoxybenzylidene)]-7-O-(triethylsilyl)paclitaxel
Deacetyltaxol
7-O-(TRIETHYLSILYL) BACCATIN III
1of4
7β,10β-diMethoxy-10-deacetylbaccatin III
Cabazitaxel interMediate 1
7,10-MeO-10-DAB
7β,10β-Dimethoxy-10-dabⅢ
7β,10β-diMethoxy-10-DAB-II
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxe
7,1-DiMethoxy-1-DAB III
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-oneChemicalBook
(2aR
11-dihydroxy-4
11-methano-5H-cyclodeca[3
11S
12b-dodecahydro-9
12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1
12S
13-tetramethyl-7
2-b]oxet-5-oneChemicalBook
4]benz[1
6-dimethoxy-4a
2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-diMethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-Methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
7,10-Dimethoxy-10-DAB III (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
4-Deacetyl-4-propionyl Cabazitaxel
Cabazitaxel Impurity 17
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
7,10-Dimethoxy-10-DAB III
(2aR,4S,4aS,6R,9S,11S,12S,12
10-Deacetyl-7,10-dimethoxy-Baccatin III
Cabazitaxel intermediate
Cabazitaxel IMP
Cabazitaxel Deacyl Impurity
Cabazitaxel Initiator 1 impurity A
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
Cabazitaxel lmpurities
4,6-Dimethoxy Baccatin III
7β,10β-dimethoxy-10-DAB-III
(2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-di...
183133-94-0 7, 10-Dimethoxy-10-DAB III
7,10-dimethoxy -10-DAB
7,10-dimethoxy-Baccatin III
10-Dimethoxy-10-DAB III
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,15-dihydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-on
7,10-dimethoxy-Baccatin
7β,10β-Dimethyl-10-deacetylbaccatinIII
7,10-Dimethoxy-10-DA
(4R,5S)-5-((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-12-(benzoyloxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl) 3-tert-butyl 2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate
(4R,5S)-5-((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-12-(benzoyloxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca
12a
Cabazitaxel Impurity
183133-94-0
API
Intermediates
183133-94-0
