HM30181 (Mesylate)
- CAS No.
- 849675-87-2
- Chemical Name:
- HM30181 (Mesylate)
- Synonyms
- Encequidar mesylate;HM30181A mesylate;HM30181 (Mesylate);PEKXWELLWNPUOK-UHFFFAOYSA-N;Encequidar mesylate (HM-30181;Encequidar mesylate, 10 mM in DMSO;HM30181 mesylate (Encequidar mesylate);Encequidar mesylate (HM30181 (mesylate));HM30181 mesylate (Synonyms: Encequidar mesylate);N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate
- CBNumber:
- CB42668516
- Molecular Formula:
- C39H40N6O10S
- Molecular Weight:
- 784.84
- MDL Number:
- MOL File:
- 849675-87-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO:25.0(Max Conc. mg/mL);31.85(Max Conc. mM) |
| form | Solid |
| color | Light yellow to yellow |
| InChIKey | PEKXWELLWNPUOK-UHFFFAOYSA-N |
| SMILES | S(O)(=O)(=O)C.N(C1C=C(OC)C(OC)=CC=1C1N=NN(C2C=CC(CCN3CCC4=CC(OC)=C(OC)C=C4C3)=CC=2)N=1)C(C1=CC(=O)C2=CC=CC=C2O1)=O |
| FDA UNII | I089S56002 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H335 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
HM30181 (Mesylate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ZIB67587 | Encequidar mesylate | 849675-87-2 | 25mg | $775.75 | 2026-06-05 | Buy |
| Biosynth | ZIB67587 | Encequidar mesylate | 849675-87-2 | 50mg | $1241.5 | 2026-06-05 | Buy |
| Biosynth | ZIB67587 | Encequidar mesylate | 849675-87-2 | 100mg | $1728 | 2026-06-05 | Buy |
| ChemScene | CS-0007532 | Encequidar (mesylate) 99.82% | 849675-87-2 | 5mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-0007532 | Encequidar (mesylate) 99.82% | 849675-87-2 | 10mg | $108 | 2026-06-04 | Buy |
HM30181 (Mesylate) Chemical Properties, Uses, Production
Uses
Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor.
in vivo
The plasma concentrations of Encequidar (HM30181) are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar (HM30181) in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction[1].
References
[1] Kim JC, et al. Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of NSC 125973 as a novel P-glycoprotein inhibitor. Int J Pharm. 2016 Jun 15;506(1-2):93-101. DOI:10.1016/j.ijpharm.2016.04.034
[2] Joo KM, et al. Response of brain specific microenvironment to P-glycoprotein inhibitor: an important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors. Int J Oncol. 2008 Oct;33(4):705-12. PMID:18813783
HM30181 (Mesylate) Preparation Products And Raw materials
Raw materials
Preparation Products
HM30181 (Mesylate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Shanyuan pharmaceutical technology co., LTD | 021-31761238 13167072949 | 3146446224@qq.com | China | 1420 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
View Latest Price from HM30181 (Mesylate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Encequidar mesylate
849675-87-2
|
$56.00-157.00 | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Encequidar mesylate
849675-87-2
|
$56.00-157.00 | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | HM30181 (Mesylate)
849675-87-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Encequidar mesylate
849675-87-2
- $56.00-157.00
- 99.84%
- TargetMol Chemicals Inc.
-
- Encequidar mesylate
849675-87-2
- $56.00-157.00
- 99.84%
- TargetMol Chemicals Inc.
-
- HM30181 (Mesylate)
849675-87-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
