ChemicalBook >> CAS DataBase List >>6-(Trifluoromethyl)nicotinoyl chloride
6-(Trifluoromethyl)nicotinoyl chloride
- CAS No.
- 358780-13-9
- Chemical Name:
- 6-(Trifluoromethyl)nicotinoyl chloride
- Synonyms
- 6-(TRIFLUOROMETHYL)NICOTINYL CHLORIDE;6-(Trifluoromethyl)nicotinoyl chloride;6-(Trifluoromethyl)nicotinoylchloride98%;6-(Trifluoromethyl)nicotinoyl chloride 98%;6-(trifluoromethyl)-3-pyridinecarbonyl chloride;6-(Trifluoromethyl)pyridine-3-carbonyl chloride;3-Pyridinecarbonyl chloride, 6-(trifluoromethyl)-;6-(Trifluoromethyl)nicotinoyl chloride, tech grade;6-(Trifluoromethyl)pyridine-3-carbonyl chloride 97%;3-Pyridinecarbonyl chloride, 6-(trifluoromethyl)- (9CI)
- CBNumber:
- CB4267230
- Molecular Formula:
- C7H3ClF3NO
- Molecular Weight:
- 209.55
- MDL Number:
- MFCD01862645
- MOL File:
- 358780-13-9.mol
- MSDS File:
- SDS
Last updated:2026-09-12 18:52:43
| Boiling point | 54 °C2 mm Hg(lit.) |
|---|---|
| Density | 1.438 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 228 °F |
| storage temp. | 2-8°C |
| form | solid |
| pka | -2.05±0.22(Predicted) |
| color | Colourless to white loe melting |
| Sensitive | Moisture Sensitive |
| InChI | 1S/C7H3ClF3NO/c8-6(13)4-1-2-5(12-3-4)7(9,10)11/h1-3H |
| InChIKey | DDIXMUVENCORLG-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1ccc(cn1)C(Cl)=O |
| CAS DataBase Reference | 358780-13-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H314 |
| Precautionary statements | P270-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | C |
| Risk Statements | 22-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3265 8/PG 3 |
| WGK Germany | 3 |
| Hazard Note | Corrosive |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 2933399990 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Acute Tox. 4 Oral Skin Corr. 1B |
6-(Trifluoromethyl)nicotinoyl chloride price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 640069 | 6-(Trifluoromethyl)pyridine-3-carbonyl chloride 97% | 358780-13-9 | 1g | $143 | 2023-06-20 | Buy |
| Sigma-Aldrich | 640069 | 6-(Trifluoromethyl)pyridine-3-carbonyl chloride 97% | 358780-13-9 | 5g | $592 | 2023-06-20 | Buy |
| Usbiological | 289689 | 6-(Trifluoromethyl)nicotinoyl chloride Asreported | 358780-13-9 | 500mg | $326 | 2026-06-03 | Buy |
| Usbiological | 289689 | 6-(Trifluoromethyl)nicotinoyl chloride Asreported | 358780-13-9 | 1g | $452 | 2026-06-03 | Buy |
| Usbiological | 289689 | 6-(Trifluoromethyl)nicotinoyl chloride Asreported | 358780-13-9 | 2g | $642 | 2026-06-03 | Buy |
6-(Trifluoromethyl)nicotinoyl chloride Chemical Properties, Uses, Production
Synthesis
Using a syringe, 6-(trifluoromethyl)nicotinic acid (45 g, 235.5 mmol), dichloromethane (540 mL), and DMF (0.910 mL, 11.77 mmol) were added to a 1 L three-necked flask equipped with a top-mounted stirrer, a Claisen adapter, a nitrogen bubbler, a 60 mL feeding funnel, and a thermocouple. Oxaloyl chloride (24.51 mL, 282.56 mmol) was added to the solution, and the reaction mixture was stirred overnight at ambient temperature. The reaction mixture was then filtered, and the filtrate was concentrated under vacuum to obtain the title compound as a brownish semi-solid.
Application
6-Trifluoromethylnicotinic acid chloride is an organic intermediate that can be used in acylation reactions. It can be prepared in one step from 6-(trifluoromethyl)nicotinic acid and oxalyl chloride.
6-(Trifluoromethyl)nicotinoyl chloride Preparation Products And Raw materials
Global Suppliers ( 102)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Labex Corporation | +91-11-26135922 or +91-11-46160359 | labex@labex.net | India | 389 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
View Latest Price from 6-(Trifluoromethyl)nicotinoyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-26 | 6-TrifluoroMethylnicotinoyl chloride
358780-13-9
|
1KG | 99.0%+ | 600 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 6-TrifluoroMethylnicotinoyl chloride
358780-13-9
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
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358780-13-9
C7 and C8
Heterocyclic Building Blocks
Pyridines
ACIDHALIDE
Heterocycles
Building Blocks
C6 to C7
Chemical Synthesis
Heterocyclic Building Blocks
