PHACLOFEN
- CAS No.
- 114012-12-3
- Chemical Name:
- PHACLOFEN
- Synonyms
- PHACLOFEN;PHACLOFEN GABA(B) RECEPTOR ANTA;3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;3-amino-2-(4-chlorophenyl)*propanephosphonic acid;(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-;Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-;Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci
- CBNumber:
- CB4272748
- Molecular Formula:
- C9H13ClNO3P
- Molecular Weight:
- 249.63
- MDL Number:
- MFCD00069328
- MOL File:
- 114012-12-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 249-252 °C |
|---|---|
| Boiling point | 467.1±55.0 °C(Predicted) |
| Density | 1.432±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | 0.1 M HCl: 13.3 mg/mL |
| form | solid |
| pka | 1.87±0.10(Predicted) |
| color | white |
| InChI | 1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14) |
| InChIKey | VSGNGLJPOGUDON-UHFFFAOYSA-N |
| SMILES | NCC(CP(O)(O)=O)c1ccc(Cl)cc1 |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
PHACLOFEN price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P118 | Phaclofen solid | 114012-12-3 | 5mg | $243 | 2026-04-30 | Buy |
| Sigma-Aldrich | P118 | Phaclofen solid | 114012-12-3 | 25mg | $918 | 2026-04-30 | Buy |
| Usbiological | 462346 | Phaclofen | 114012-12-3 | 5mg | $340 | 2026-06-03 | Buy |
| Usbiological | 462346 | Phaclofen | 114012-12-3 | 10mg | $468 | 2026-06-03 | Buy |
| Usbiological | 256229 | Phaclofen Asreported | 114012-12-3 | 10mg | $389 | 2026-06-03 | Buy |
PHACLOFEN Chemical Properties, Uses, Production
Uses
Phaclofen is a selective GABABreceptor antagonist.
General Description
Phaclofen is a phosphonic acid derivative of baclofen.
Biological Activity
Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).
Biochem/physiol Actions
Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and () baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.
in vivo
Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus[4].
Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum[5].
Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes[3].
| Animal Model: | Sprague–Dawley rats (180–250 g)[4] |
| Dosage: | 2 mg/kg |
| Administration: | I.p． |
| Result: | Fewer neuropeptide Y-like immunoreactive fibers were detected in the stimulated cuneate nucleus. |
| Animal Model: | Male Wistar rats (280–320 g)[5] |
| Dosage: | 2 mg/kg |
| Administration: | S.c. |
| Result: | Antagonized the effects of 6 mg/kg R(＋) baclofen in dorsal striatum. |
PHACLOFEN Preparation Products And Raw materials
Raw materials
Preparation Products
PHACLOFEN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824; | bjkaida@163.com | China | 1597 | 59 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Nanjing LuoDa Chemical Co., Ltd | 025-66016961 13382082786; | China | 276 | 55 | |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2445 | 58 |
