(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
- CAS No.
- 90719-30-5
- Chemical Name:
- (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
- Synonyms
- UIC-1005;Locostatin - UIC 1005;Locostatin >=98% (HPLC);(R)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE;(N-CROTONYL)-(4S)-BENZYL-2-OXAZOLIDINONE;(N-Crotonyl)-(R)-4-benzyl-2-oxazolidinone;4-but-2-enyl-3-propan-2-yl-2-oxazolidinone;(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE;(4S)-N-Crotonyl-4-benzyl-2-oxazolidinone,99%
- CBNumber:
- CB4284497
- Molecular Formula:
- C14H15NO3
- Molecular Weight:
- 245.27
- MDL Number:
- MFCD00278769
- MOL File:
- 90719-30-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Locostatin ≥98% (HPLC) | L5670 | 10mg | $72.7 |
| Locostatin ≥98% (HPLC) | L5670 | 50mg | $281 |
| Locostatin | QDA71930 | 50mg | $540 |
| Locostatin | QDA71930 | 100mg | $865 |
| Locostatin | QDA71930 | 250mg | $1620 |
| Melting point | 84-88 °C(lit.) |
|---|---|
| Boiling point | 351.0±25.0 °C(Predicted) |
| Density | 1.205±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥30mg/mL |
| form | powder |
| pka | -1+-.0.40(Predicted) |
| color | white to off-white |
| InChI | 1S/C14H15NO3/c1-2-6-13(16)15-12(10-18-14(15)17)9-11-7-4-3-5-8-11/h2-8,12H,9-10H2,1H3/b6-2+/t12-/m0/s1 |
| InChIKey | UTZAFVPPWUIPBH-QSLRECBCSA-N |
| SMILES | C\C=C\C(=O)N1[C@H](COC1=O)Cc2ccccc2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L5670 | Locostatin ≥98% (HPLC) | 90719-30-5 | 10mg | $72.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | L5670 | Locostatin ≥98% (HPLC) | 90719-30-5 | 50mg | $281 | 2026-04-30 | Buy |
| Biosynth | QDA71930 | Locostatin | 90719-30-5 | 50mg | $540 | 2026-06-04 | Buy |
| Biosynth | QDA71930 | Locostatin | 90719-30-5 | 100mg | $865 | 2026-06-04 | Buy |
| Biosynth | QDA71930 | Locostatin | 90719-30-5 | 250mg | $1620 | 2026-06-04 | Buy |
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Chemical Properties,Uses,Production
Uses
Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
Biochem/physiol Actions
Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
in vivo
Locostatin (0.5 mg/kg; i.p.; once a day for 7 days) aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice[3].
| Animal Model: | 6 weeks, 18-22 g, male ICR mice (TAA model; injected intraperitoneally with 300 mg/kg TAA once a day for 2 days)[3] |
| Dosage: | 0.5 mg/kg |
| Administration: | I.p.; once a day for 7 days |
| Result: | Decreased the expression of RKIP, led to more severe damage, such as steatosis and hepatic lesions, increased the production of ROS in the liver and TNF-α, IL-6 and IL-1β in the sera of mice with acute liver injury, inhibitd Nrf2 and HO-1 expression in the livers of mice, induced NF-κB activation in the livers of mice,increased the phosphorylation of JNK, p38 and ERK in liver tissues. |
References
[1] Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. DOI:10.1615/forumimmundisther.v2.i1.60
[2] Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. DOI:10.1002/1439-7633(20021104)3:11<1105::AID-CBIC1105>3.0.CO;2-S
[3] Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998. DOI:10.3892/etm.2018.6542
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Preparation Products And Raw materials
Raw materials
Preparation Products
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40228 | 62 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17770 | 75 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
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