(R)-1,4-Benzodioxane-2-carboxylic acid
- CAS No.
- 70918-53-5
- Chemical Name:
- (R)-1,4-Benzodioxane-2-carboxylic acid
- Synonyms
- (R)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid;UNII:T9Z56HV1B0;(R)-1,4-BENZODIOXAN 2-CARBOXYLIC ACID;(R)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID;(R)-1,4-Benzodioxane-2-carboxylic acid;(R)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-CARBOXYLIC ACID;(2R)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid;(3R)-2,3-Dihydro-1,4-benzodioxine-3-carboxylic acid;(R)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID;1,4-Benzodioxin-2-carboxylic acid, 2,3-dihydro-, (2R)-
- CBNumber:
- CB4290760
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD00239407
- MOL File:
- 70918-53-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 96-99 °C |
|---|---|
| Boiling point | 347.2±41.0 °C(Predicted) |
| alpha | 83 º (c=1.5% in chloroform) |
| Density | 1.379±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 2.69±0.20(Predicted) |
| form | solid |
| color | Pale yellow |
| optical activity | [α]20/D +83±2°, c = 1.5% in chloroform |
| BRN | 5742837 |
| InChI | 1S/C9H8O4/c10-9(11)8-5-12-6-3-1-2-4-7(6)13-8/h1-4,8H,5H2,(H,10,11)/t8-/m1/s1 |
| InChIKey | HMBHAQMOBKLWRX-MRVPVSSYSA-N |
| SMILES | OC(=O)[C@H]1COc2ccccc2O1 |
| CAS DataBase Reference | 70918-53-5(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 2932990090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
(R)-1,4-Benzodioxane-2-carboxylic acid price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 463761 | (R)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylic Acid | 70918-53-5 | 100mg | $355 | 2026-06-03 | Buy |
| Usbiological | 463761 | (R)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylic Acid | 70918-53-5 | 250mg | $475 | 2026-06-03 | Buy |
| AstaTech | 60392 | (R)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID 97% | 70918-53-5 | 0.25G | $44 | 2026-04-30 | Buy |
| AstaTech | 60392 | (R)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID 97% | 70918-53-5 | 1G | $123 | 2026-04-30 | Buy |
| AstaTech | 60392 | (R)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID 97% | 70918-53-5 | 5G | $474 | 2026-04-30 | Buy |
(R)-1,4-Benzodioxane-2-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White crystalline powder
Uses
(R)-1,4-Benzodioxane-2-carboxylic acid is a chiral synthon mostly used in the preparation of doxazosin mesylate, a drug treating benign prostatic hyperplasia.
Synthesis
3663-82-9
3663-80-7
General procedure for the synthesis of 4-benzodioxane-2-carboxylic acid from (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol: Accurately weigh (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol, and dissolve it in 0.3 N aqueous KOH (1.3 equiv). Potassium permanganate (KMnO4, 2.0 eq.) was slowly added under ice bath conditions at 0 °C. The reaction mixture was first stirred at low temperature for about 10 minutes, then brought to room temperature and continued to stir overnight. Upon completion of the reaction, the organic phase was extracted with dichloromethane, the organic phase was washed with water sequentially, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a white solid, i.e., the crude product of 4-benzodioxane-2-carboxylic acid. The crude product was purified by silica gel fast column chromatography, and the final pure product was obtained in 92.5% yield.
References
[1] Patent: CN105985328, 2016, A. Location in patent: Paragraph 0063; 0071; 0072
(R)-1,4-Benzodioxane-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
View Latest Price from (R)-1,4-Benzodioxane-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | (R)-1,4-Benzodioxane-2-carboxylic acid
70918-53-5
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- (R)-1,4-Benzodioxane-2-carboxylic acid
70918-53-5
- $6.68
- 97%-99%
- Career Henan Chemical Co
