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Methyl L-tryptophanate hydrochloride

Methyl L-tryptophanate hydrochloride structure

CAS No.: 7524-52-9

Chemical Name:: Methyl L-tryptophanate hydrochloride

Synonyms: L-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE;H-Trp-Ome;L-Trp-OMe.HCL;H-TRP-OME·HCL;(S)-Methyl 2-aMino-3-(1H-indol-3-yl)propanoate hydrochloride;Trp-Ome.HCl;H-Trp-OMe·HC;H-TRP-OME HCL;H-L-Trp-OMe*HCl;TRYPTOPHAN-OME HCL

CBNumber:: CB4292113

Molecular Formula:: C12H15ClN2O2

Molecular Weight:: 254.71

MDL Number:: MFCD00066134

MOL File:: 7524-52-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:16:06

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Methyl L-tryptophanate hydrochloride Properties

Melting point	218-220 °C(lit.)
alpha	18 º (c=5 CH3OH)
refractive index	19.5 ° (C=5, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Sparingly)
form	Powder
color	White to off-white
optical activity	[α]20/D +18°, c = 5 in methanol
BRN	4240280
Major Application	peptide synthesis
Cosmetics Ingredients Functions	HAIR CONDITIONING
InChI	InChI=1/C12H14N2O2.ClH/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11;/h2-5,7,10,14H,6,13H2,1H3;1H/t10-;/s3
InChIKey	XNFNGGQRDXFYMM-MEQOOBBNNA-N
SMILES	C12C=CC=CC=1NC=C2C[C@H](N)C(=O)OC.Cl \|&1:10,r\|
CAS DataBase Reference	7524-52-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	AU62O6861L
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314

Precautionary statements

P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

22-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

Methyl L-tryptophanate hydrochloride price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	364517	L-Tryptophan methyl ester hydrochloride 98%	7524-52-9	5g	$49.6	2026-04-30	Buy
Sigma-Aldrich	PHR2601	L-Tryptophan methyl ester hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material	7524-52-9	100mg	$677	2026-04-30	Buy
Sigma-Aldrich	364517	L-Tryptophan methyl ester hydrochloride 98%	7524-52-9	25g	$141	2026-04-30	Buy
TCI Chemical	T1657	L-Tryptophan Methyl Ester Hydrochloride >98.0%(HPLC)(T)	7524-52-9	5g	$33	2026-04-30	Buy
TCI Chemical	T1657	L-Tryptophan Methyl Ester Hydrochloride >98.0%(HPLC)(T)	7524-52-9	25g	$103	2026-04-30	Buy

Product number	Packaging	Price	Buy
364517	5g	$49.6	Buy
PHR2601	100mg	$677	Buy
364517	25g	$141	Buy
T1657	5g	$33	Buy
T1657	25g	$103	Buy

Methyl L-tryptophanate hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Methyl L-tryptophanate hydrochloride is White to off-white powder

Uses

Amino acid derivative that may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550).

Uses

L-Tryptophan methyl ester hydrochloride can be used as a reactant to prepare:

Oxamoyl derivatives of N-(2-aminobenzoyl)-L-tryptophan (dipeptides) by acylation reaction with 3,1-benzoxazinones.
Tadalafil (Cialis), a type-V phosphodiesterase (PDE5) inhibitor.
Isoroquefortine C.

Uses

Methyl L-tryptophanate hydrochloride may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550)

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

73-22-3

7524-52-9

(2) Preparation of L-tryptophan methyl ester hydrochloride: 60 mL of methanol was added to a 100 mL round-bottomed flask under ice bath conditions. Subsequently, 4 mL of sulfoxide chloride (SOCl2) was slowly added dropwise through a constant-pressure dropping funnel (equipped with a drying tube at the top), and NaOH solution was used to absorb the resulting exhaust gas. After the reaction mixture was reacted under stirring conditions for 1 h, 8 mmol of L-tryptophan (3d) was added and stirring was continued for 30 min at room temperature. After that, the reaction system was warmed up to 66 °C and the reaction was refluxed for 6 hours. The reaction process was monitored by thin-layer chromatography (TLC) using 2% ninhydrin ethanol solution as a color developer until the raw material spot disappeared. Upon completion of the reaction, the solvent was removed by evaporation to give L-tryptophan methyl ester hydrochloride in 100% yield.

References

[1] Tetrahedron, 2001, vol. 57, # 51, p. 10181 - 10189
[2] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0111
[3] European Journal of Medicinal Chemistry, 2016, vol. 114, p. 318 - 327
[4] New Journal of Chemistry, 2018, vol. 42, # 16, p. 13549 - 13557
[5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 41, p. 8280 - 8287

Methyl L-tryptophanate hydrochloride Preparation Products And Raw materials

Raw materials

Methanol L-Tryptophan Thionyl chloride Ethanol

Preparation Products

Methyl L-tryptophanate hydrochloride Suppliers

Global( 423)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Awesome （Beijing）TechnologyCo.,Ltd.	18201687790 18201687790	yunbo12291229@163.com	China	137	58
Shanghai Kaipu New Biotechnology Co. , Ltd.	17821452002; 17821452002	info@shanghaikaipuxin.com	China	35	58
Nanjing Danron Bio-New Materials Co.Ltd	18936428028 18936428028	3806853067@qq.com	China	147	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Awesome （Beijing）TechnologyCo.,Ltd.	58
Shanghai Kaipu New Biotechnology Co. , Ltd.	58
Nanjing Danron Bio-New Materials Co.Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
future industrial shanghai co., ltd	65
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81

View Lastest Price from Methyl L-tryptophanate hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	H-L-Trp-OMe.HCl 7524-52-9		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2025-12-24	L-TRYPTOPHAN METHYL ESTER HCL 7524-52-9		1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2024-01-08	Methyl L-tryptophanate hydrochloride 7524-52-9	$9.00	1KG	99%	50000tons	Wuhan Boyuan Import & Export Co., LTD

H-L-Trp-OMe.HCl
7524-52-9
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

L-TRYPTOPHAN METHYL ESTER HCL
7524-52-9
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

Methyl L-tryptophanate hydrochloride
7524-52-9
$9.00
99%
Wuhan Boyuan Import & Export Co., LTD

Methyl L-tryptophanate hydrochloride Spectrum

Methyl L-tryptophanate hydrochloride(7524-52-9)MS Methyl L-tryptophanate hydrochloride(7524-52-9)¹HNMR Methyl L-tryptophanate hydrochloride(7524-52-9)¹³CNMR Methyl L-tryptophanate hydrochloride(7524-52-9)IR1 Methyl L-tryptophanate hydrochloride(7524-52-9)IR2

7524-52-9(Methyl L-tryptophanate hydrochloride)Related Search:

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1of4

L-A-AMINO-3-INDOLEPROPIONIC ACID METHYL ESTER HYDROCHLORIDE L-2-AMINO-3-INDOLYLPROPANOIC ACID METHYL ESTER HYDROCHLORIDE L-B-3-INDOLYLALANINE METHYL ESTER HYDROCHLORIDE H-TRP-OME HCL TRYPTOPHAN-OME HCL L-TRYPTOPHAN METHYL ESTER HCL L-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE SALT METHYL L-TRYPTOPHANATE HYDROCHLORIDE L-Tryptophan Methyl ester hydrochloride 98% L-Tryptophan Methyl Ester Hydrochloride, 98.0%(LC&T (S)-Methyl 2-aMino-3-(1H-indol-3-yl)propanoate hydrochloride L-Tryptophan methyl ester hydrochloride≥ 99% (HPLC) Methyl L-Tryptophanate Hydrochloride,99%e.e. H-TRP-OME·HCL methyl L-tryptophanate monohydrochloride METHYL TRYPTOPHANATE HCL L-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE 98+% Trp-Ome.HCl L-Tryptophan, methyl ester, monohydrochloride H-L-Trp-OMe*HCl L-Tryptophane methyl ester hydrochloride L-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE extrapure Tryptophan methyl·hydrochloric acid Tryptophan methyl·hydrochloride (S)-Tryptophan Methyl Ester Monohydrochloride Methyl (2S)-2-aMino-3-(1H-indol-3-yl)propanoate hydrochloride H-Trp-OMe·HCl L-tryptophan Methyl ester hydrochloride 2-(HydroxyMethyl)pyridine (Hydrochloride) Methyl L-Tryptophanate Hydrochloride H-Trp-OMe.HCl [(2S)-3-(1H-indol-3-yl)-1-methoxy-1-oxopropan-2-yl]ammonium L-Tryptophan, methylester, hydrochloride (1:1) methyl L-tryptophanate Hcl L-Tryptophan Methyl Ester Hydrochlo L-Tryptophan methyl ester hydrochloride, 98%, for synthesis H-Trp-OMe·HC -Tryptophan MethyL Tryptophan Impurity 4 (L-Tryptophan Methyl Ester) Tryptophan Impurity 50 Methyl L-tryptophanate hydrochloride USP/EP/BP Methyl L-tryptophanate hydrochlorideMethyl L-tryptophanate hydrochloride L-Tryptophan methyl ester hydrochloride Tryptophan Impurity 4 HCl H-Trp-Ome L-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE L-Trp-OMe.HCL 7524-52-9 ESTER Amino Acid Derivatives Specialty Synthesis Tryptophan Peptide Synthesis Amino Acids (C-Protected) Tryptophans Indoles Amino Acid Methyl Esters Protected & Labeled Amino Acids Amino Acids & Derivatives Aromatics