Ethyl methanesulfonate
- CAS No.
- 62-50-0
- Chemical Name:
- Ethyl methanesulfonate
- Synonyms
- EMS;ETHYL MESYLATE;METHANESULFONIC ACID ETHYL ESTER;CB 1528;Ethyl methansulfonate;ETHYL METHANESULPHONATE;ethylesterofmethylsulfonicacid;ethylesterofmethanesulfonicacid;ethylesterofmethylsulphonicacid;ethylesterofmethanesulphonicacid
- CBNumber:
- CB4292779
- Molecular Formula:
- C3H8O3S
- Molecular Weight:
- 124.16
- MDL Number:
- MFCD00007559
- MOL File:
- 62-50-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl methanesulfonate liquid | M0880 | 1g | $49 |
| Ethyl methanesulfonate for synthesis | 8.20774 | 5ml | $51.4 |
| Ethyl methanesulfonate for synthesis | 8.20774 | 25mL | $167 |
| Ethyl methanesulfonate certified reference material, TraceCERT | 72945 | 120mg | $144 |
| Ethyl Methanesulfonate >99.0%(GC) | M0607 | 25g | $46 |
| More product size | |||
| Melting point | <25 °C |
|---|---|
| Boiling point | 85-86 °C/10 mmHg (lit.) |
| Density | 1.206 g/mL at 20 °C |
| vapor pressure | 0.27 hPa (25 °C) |
| refractive index |
n |
| Flash point | 100 °C |
| storage temp. | 2-8°C |
| solubility | 50-100g/l |
| form | liquid |
| color | Colourless to Pale Yellow |
| Water Solubility | Miscible with water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,3827 |
| BRN | 773969 |
| Henry's Law Constant | 3.8×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Stability | Stable. Combustible. Incompatible with water, alkalies, oxidizing agents. |
| Major Application |
environmental pharmaceutical |
| InChI | 1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3 |
| InChIKey | PLUBXMRUUVWRLT-UHFFFAOYSA-N |
| SMILES | CCOS(C)(=O)=O |
| CAS DataBase Reference | 62-50-0(CAS DataBase Reference) |
| FDA UNII | 9H154DI0UP |
| IARC | 2B (Vol. 7, Sup 7) 1987 |
| NIST Chemistry Reference | Methanesulfonic acid, ethyl ester(62-50-0) |
| Proposition 65 List | Ethyl Methanesulfonate |
| EPA Substance Registry System | Ethyl methanesulfonate (62-50-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H319-H340-H350-H361f | |||||||||
| Precautionary statements | P202-P280-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 46-22-40-36/37/38-45 | |||||||||
| Safety Statements | 53-23-36/37/39-45-36/37-37/39-26 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PB2100000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29041000 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 4 Oral Carc. 1B Eye Irrit. 2 Muta. 1B Repr. 2 Skin Irrit. 2 Skin Sens. 1 |
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| Hazardous Substances Data | 62-50-0(Hazardous Substances Data) | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Ethyl methanesulfonate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M0880 | Ethyl methanesulfonate liquid | 62-50-0 | 1g | $49 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.20774 | Ethyl methanesulfonate for synthesis | 62-50-0 | 5ml | $51.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.20774 | Ethyl methanesulfonate for synthesis | 62-50-0 | 25mL | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | 72945 | Ethyl methanesulfonate certified reference material, TraceCERT | 62-50-0 | 120mg | $144 | 2026-04-30 | Buy |
| TCI Chemical | M0607 | Ethyl Methanesulfonate >99.0%(GC) | 62-50-0 | 25g | $46 | 2026-04-30 | Buy |
Ethyl methanesulfonate Chemical Properties,Uses,Production
Chemical Properties
colourless liquid
Chemical Properties
Ethyl methane sulfonate is a clear liquid.
Uses
Experimentally as mutagen, teratogen and brain carcinogen.
Uses
Ethyl methanesulfonate is used as mutagen for both mammalian and plant cells. It finds application as a model alkylating agent in the study of deoxyribonucleic acid (DNA) repair processes.
Definition
ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol.
General Description
Clear colorless liquid. Denser than water.
Air & Water Reactions
Water soluble.
Reactivity Profile
Ethyl methanesulfonate alkylates nucleophiles such as hydroxy, amino and sulfhydryl groups in model and biological materials. Is hydrolyzed by excess aqueous alkali to non-corrosive and non-toxic products. Is hydrolyzed by water to a highly corrosive product .
Fire Hazard
Ethyl methanesulfonate is combustible.
Biochem/physiol Actions
Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES and ESTERS.
Synthesis
64-17-5
124-63-0
62-50-0
Ethanol (6.40 mL, 110 mmol) was dissolved in anhydrous dichloromethane (400 mL) and cooled in an ice bath to 0°C. Subsequently, N-methylmorpholine (22.0 mL, 200 mmol) and methanesulfonyl chloride (7.70 mL, 100 mmol) were slowly added to the solution and stirring was continued for 30 minutes under ice bath conditions. Upon completion of the reaction, the ice bath was removed and the reaction mixture was continued to be stirred at room temperature overnight. At the end of the reaction, the mixture was diluted by adding dichloromethane (200 mL), and the organic layer was washed sequentially with aqueous potassium bisulfate (1.0 M, 2 × 200 mL) and deionized water (200 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford ethyl methanesulfonate as a colorless oil (10 g, 80 mmol, 81% yield). The product characterization data were consistent with literature reports.
Potential Exposure
Used as a research tool for mutagenesis and carcinogenesis studies. Was considered as a possible human male contraceptive. Also considered as a reversible male hemosterilant for insects and mammalian pests.
Carcinogenicity
Ethyl methanesulfonate is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.
Incompatibilities
Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Contact with moisture may cause hydrolysis or other forms of decomposition
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 16, p. 3429 - 3435
[2] Journal of the Chemical Society, 1995, p. 7 2420
[3] Journal of Organic Chemistry, 1967, vol. 32, p. 308 - 317
[4] Journal of Organic Chemistry, 1970, vol. 35, p. 1226 - 1227
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 10, p. 2807 - 2813
Ethyl methanesulfonate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei baicao biology science and technology co., ltd | +86-19131911055 +8617824879454 | zhang@hbbocao.com | China | 1029 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5233 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
View Lastest Price from Ethyl methanesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | Ethyl Mesilate
62-50-0
|
US $1.10-9.90 / KG | 1KG | 99% min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-03-20 | Ethyl methanesulfonate
62-50-0
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-12 | Ethyl methyl sulfonate
62-50-0
|
US $1.00-0.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- Ethyl Mesilate
62-50-0
- US $1.10-9.90 / KG
- 99% min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Ethyl methanesulfonate
62-50-0
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl methyl sulfonate
62-50-0
- US $1.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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