6-Fluoro-1H-indazol-3-ylamine
- CAS No.
- 404827-75-4
- Chemical Name:
- 6-Fluoro-1H-indazol-3-ylamine
- Synonyms
- 6-fluoro-1H-indazol-3-aMine;6-Fluoro-2h-indazol-3-amine;6-Fluoro-1H-indazol-3-ylamine;6-Fluoro-1H-indazol-4-ylamine;1H-Indazol-3-amine, 6-fluoro-;1H-Indazol-3-amine,6-fluoro-(9CI)
- CBNumber:
- CB4296742
- Molecular Formula:
- C7H6FN3
- Molecular Weight:
- 151.14
- MDL Number:
- MFCD06739129
- MOL File:
- 404827-75-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 152-154 °C |
|---|---|
| Boiling point | 379.288±22.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.488±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 13.918±0.10(predicted) |
| Appearance | Light yellow to yellow Solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2933998090 |
6-Fluoro-1H-indazol-3-ylamine price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 277774 | 6-Fluoro-1H-indazol-3-ylamine Asreported | 404827-75-4 | 50mg | $373 | 2026-06-03 | Buy |
| Usbiological | 277774 | 6-Fluoro-1H-indazol-3-ylamine Asreported | 404827-75-4 | 100mg | $519 | 2026-06-03 | Buy |
| Usbiological | 277774 | 6-Fluoro-1H-indazol-3-ylamine Asreported | 404827-75-4 | 250mg | $644 | 2026-06-03 | Buy |
| Usbiological | 277774 | 6-Fluoro-1H-indazol-3-ylamine Asreported | 404827-75-4 | 500mg | $871 | 2026-06-03 | Buy |
| Usbiological | 277774 | 6-Fluoro-1H-indazol-3-ylamine Asreported | 404827-75-4 | 1g | $1188 | 2026-06-03 | Buy |
6-Fluoro-1H-indazol-3-ylamine Chemical Properties, Uses, Production
Synthesis
3939-09-1
404827-75-4
General procedure for the synthesis of 3-amino-6-fluoro-1H-indazole from 2,4-difluorobenzonitrile: 2,4-difluorobenzonitrile (10.00 g, 71.89 mmol) was placed in a 500 mL two-necked round-bottomed flask and n-butanol (200 mL) was added as a solvent. Hydrazine hydrate (70.0 mL, 1443 mmol) was slowly added to the reaction system under nitrogen protection. After addition, the reaction mixture was heated to 150 °C and stirred continuously for 17 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (200 mL x 3). The organic phases were combined, washed sequentially with water (200 mL x 2) and saturated saline (200 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (v/v=1/2) to afford 3-amino-6-fluoro-1H-indazole as a yellow liquid (4.85 g, 44.7% yield). Mass spectrum (ESI, positive ion mode) m/z: 152.2 ([M+H]+).
References
[1] Patent: WO2018/188590, 2018, A1. Location in patent: Paragraph 00316
[2] Patent: US2009/270405, 2009, A1. Location in patent: Page/Page column 82-83
[3] Patent: WO2011/53292, 2011, A1. Location in patent: Page/Page column 133
[4] Patent: JP5714745, 2015, B2. Location in patent: Paragraph 0264; 0265
6-Fluoro-1H-indazol-3-ylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1401 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Xi’an chemsoar Medical Technology Co., ltd | 029-86538357 | China | 234 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Shanghai Devinchem Ltd | 027-65318838 13646286950 | sales@devinchem.com | China | 2983 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4908 | 55 |
View Latest Price from 6-Fluoro-1H-indazol-3-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 6-FLUORO-1H-INDAZOL-3-YLAMINE
404827-75-4
|
1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
-
- 6-FLUORO-1H-INDAZOL-3-YLAMINE
404827-75-4
- $0.01
- 98%; 99%
- Career Henan Chemical Co
