4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde
- CAS No.
- 847560-50-3
- Chemical Name:
- 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde
- Synonyms
- 5-Formyl-2-methylphenylboronic Acid Pinacol Ester;4-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde;4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde;Benzaldehyde, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB43071788
- Molecular Formula:
- C14H19BO3
- Molecular Weight:
- 246.11
- MDL Number:
- MFCD18731017
- MOL File:
- 847560-50-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | M57868 | 100mg | $34 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | M57868 | 250mg | $38 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | M57868 | 1g | $40 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | M57868 | 5g | $170 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | AA00G8W4 | 100mg | $17 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | M57868 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | 847560-50-3 | 100mg | $34 | 2026-05-06 | Buy |
| Synthonix | M57868 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | 847560-50-3 | 250mg | $38 | 2026-05-06 | Buy |
| Synthonix | M57868 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | 847560-50-3 | 1g | $40 | 2026-05-06 | Buy |
| Synthonix | M57868 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | 847560-50-3 | 5g | $170 | 2026-05-06 | Buy |
| aablocks | AA00G8W4 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 97% | 847560-50-3 | 100mg | $17 | 2026-05-28 | Buy |
4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde Chemical Properties,Uses,Production
Synthesis
36276-24-1
73183-34-3
847560-50-3
General procedure for the synthesis of 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde from 3-bromo-4-methylbenzaldehyde and pinacol bis(borate) ester: To a stirred solution of 3-bromo-4-methylbenzaldehyde (3.0 g, 15.1 mmol) in 1,4-dioxane (30 mL) was added pinacol bis(borate) ester ( 4.5 g, 17.7 mmol) and potassium acetate (2.98 g, 30.4 mmol). The reaction mixture was degassed with nitrogen for 20 min. Subsequently, Pd(dppf)Cl2 (0.62 g, 0.75 mmol) was added. The reaction system was heated and reacted at 90 °C overnight. After completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed sequentially with water and saturated saline and then concentrated. Purification by combiflash column chromatography afforded the target product 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (3.4 g, 91.39% yield) as a yellow semi-solid.LCMS: (M + H)+ = 247.2; 1H NMR (CDCl3, 300MHz) δ 9.99 (s , 1H), 8.26 (s, 1H), 7.82-7.85 (dd, J=7.8, 1.5 Hz, 1H), 7.26-7.33 (m, 1H), 2.62 (s, 3H), 1.37 (s, 12H).
References
[1] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 79
[2] Patent: WO2014/202528, 2014, A1. Location in patent: Page/Page column 65
[3] Patent: WO2005/21552, 2005, A1. Location in patent: Page/Page column 62-63
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 3973 - 4001
4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Shanghai ShiXian Chemical Technology Co., Ltd. | 13764359345 | 990877971@qq.com | China | 1898 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai Baozhi Biological Technology Co., Ltd. | 13764058804 | 3438424070@qq.com | China | 381 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 52641 | 58 |
| Yangzhou modier Electronic Materials Co., Ltd | 13918702962 13761402923 | market@modeltemol.com | China | 7804 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 13611835272 13611835272 | mmwang@sunwaypharm.com | China | 44091 | 58 |
