Thiophene-2-sulfonamide
- CAS No.
- 6339-87-3
- Chemical Name:
- Thiophene-2-sulfonamide
- Synonyms
- BUTTPARK 44\07-11;2-Thienylsulfonamide;2-thiophenesulfonamide;Thiophene-Α-Sulfonamide;THIOPHENE-A-SULFONAMIDE;THIOPHENE-2-SULFONAMIDE;Thiophene-2-sulphonamide;THIOPHENE-ALPHA-SULFONAMIDE;THIOPHENE-2-SULFONIC ACID AMIDE;2-Thiophenesulfonamide(6CI,7CI,8CI,9CI)
- CBNumber:
- CB4308056
- Molecular Formula:
- C4H5NO2S2
- Molecular Weight:
- 163.22
- MDL Number:
- MFCD00185853
- MOL File:
- 6339-87-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 137-141 °C |
|---|---|
| Boiling point | 338.1±34.0 °C(Predicted) |
| Density | 1.513±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 9.94±0.60(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| InChI | 1S/C4H5NO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H,(H2,5,6,7) |
| InChIKey | KTFDYVNEGTXQCV-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1cccs1 |
| CAS DataBase Reference | 6339-87-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | P6Q26TS6AU |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XN0294000 | |||||||||
| HS Code | 29350090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Thiophene-2-sulfonamide price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 706655 | 2-Thiophenesulfonamide 96% | 6339-87-3 | 1g | $57.7 | 2023-06-20 | Buy |
| Sigma-Aldrich | 706655 | 2-Thiophenesulfonamide 96% | 6339-87-3 | 5g | $184 | 2023-06-20 | Buy |
| TCI Chemical | T2851 | 2-Thiophenesulfonamide >98.0%(GC) | 6339-87-3 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | T2851 | 2-Thiophenesulfonamide >98.0%(GC) | 6339-87-3 | 5g | $80 | 2026-04-30 | Buy |
| AstaTech | CL1301 | 2-THIENYLSULFONAMIDE 97% | 6339-87-3 | 25G | $44 | 2026-04-30 | Buy |
Thiophene-2-sulfonamide Chemical Properties, Uses, Production
Definition
ChEBI: 2-Thiophenesulfonamide is a member of thiophenes.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6
Synthesis
16629-19-9
6339-87-3
General procedure for the synthesis of 2-thiophenesulfonamide from 2-thiophenesulfonyl chloride: Example: preparation of 2-thiophenesulfonamide 2-Thiophenesulfonyl chloride (0.5 g, 2.74 mmol) was added to 25% ammonium hydroxide solution (5 mL, 33.45 mmol), refluxed and stirred at 50°C for 15 hours. Upon completion of the reaction, the reaction mixture was filtered while hot and the residue was washed with boiling aqueous 25% ammonium hydroxide solution. Subsequently, the ammonium hydroxide solution was removed by vacuum distillation until there was no ammonia odor. Eventually, 2-thiophenesulfonamide was recrystallized from water to give a white solid (0.328 g, 77% yield). Product Characterization: Melting point: 145-146°C; IR spectrum (KBr, cm1): 3290 (N-H stretching vibration), 3224 (N-H stretching vibration); NMR hydrogen spectrum (400 MHz, DMSO-d6, δ): 7.15 (1H, dd, J = 5.0, 3.7 Hz, C(4)H), 7.55 (1H, dd, J = 3.7, 1.4 Hz, C(3)H), 7.66 (2H, s, NH2), 7.85 (1H, dd, J = 5.0, 1.4 Hz, C(5)H); NMR carbon spectrum (100 MHz, DMSO-d6, δ): 127.3, 130.0, 131.1, 145.7; Mass spectrum (ESI): m/z 162 ([M-H] , 100%); High-resolution mass spectrum (ESI): C4H4NO2S2 ([M-H]) Calculated value 161.9689, measured value 161.9695.
References
[1] Journal of the American Chemical Society, 2010, vol. 132, # 10, p. 3238 - 3239
[2] Patent: WO2011/55142, 2011, A2. Location in patent: Page/Page column 47
[3] Phosphorus and Sulfur and the Related Elements, 1981, vol. 10, p. 111 - 120
[4] Phosphorus and Sulfur and the Related Elements, 1980, vol. 8, p. 197 - 200
[5] Justus Liebigs Annalen der Chemie, 1933, vol. 501, p. 174,182
Thiophene-2-sulfonamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Thiophene-2-sulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Thiophene-2-sulfonamide
6339-87-3
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-02-04 | 2-Thiophenesulfonamide
6339-87-3
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- Thiophene-2-sulfonamide
6339-87-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Thiophenesulfonamide
6339-87-3
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
