p-Toluenesulfonamide
- CAS No.
- 70-55-3
- Chemical Name:
- p-Toluenesulfonamide
- Synonyms
- PTSA;4-METHYLBENZENESULFONAMIDE;Tosylamide;Tosylamine;4-TOLUENESULFONAMIDE;TOLUENE-4-SULFONAMIDE;P-TOLUENESULPHONAMIDE;p-Tosylamide;p-Toluenesulfoamide;P-TOLUENESULFONYLAMIDE
- CBNumber:
- CB7330843
- Molecular Formula:
- C7H9NO2S
- Molecular Weight:
- 171.22
- MDL Number:
- MFCD00011692
- MOL File:
- 70-55-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Toluenesulfonamide for synthesis | 8.08230 | 100g | $27.5 |
| 4-Toluenesulfonamide for synthesis | 8.08230 | 1kg | $94.5 |
| 4-Toluenesulfonamide for synthesis | 8.08230 | 25kg | $607 |
| p-Toluenesulfonamide reagent grade, 98% | 105902 | 250g | $47.2 |
| p-Toluenesulfonamide reagent grade, 98% | 105902 | 1kg | $86.83 |
| More product size | |||
| Melting point | 134-137 °C (lit.) |
|---|---|
| Boiling point | 221 °C (10 mmHg) |
| Density | 1.2495 (rough estimate) |
| vapor density | 5.9 (vs air) |
| refractive index | 1.6100 (estimate) |
| Flash point | 202 °C |
| storage temp. | Store below +30°C. |
| solubility | DMSO: soluble |
| pka | 10.20±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| Odor | Odorless |
| Water Solubility | 0.32 g/100 mL (25 º C) |
| BRN | 472689 |
| Cosmetics Ingredients Functions |
PLASTICISER SKIN CONDITIONING - MISCELLANEOUS |
| InChI | 1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10) |
| InChIKey | LMYRWZFENFIFIT-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1)S(N)(=O)=O |
| LogP | 0.820 |
| Indirect Additives used in Food Contact Substances | TOLUENESULFONAMIDE, P- |
| CAS DataBase Reference | 70-55-3(CAS DataBase Reference) |
| EWG's Food Scores | 1-3 |
| FDA UNII | I8266RI90M |
| NCI Drug Dictionary | para-toluenesulfonamide |
| NIST Chemistry Reference | 4-Methylbenzenesulfonamide(70-55-3) |
| EPA Substance Registry System | p-Toluenesulfonamide (70-55-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | XT5075000 | |||||||||
| TSCA | TSCA listed | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29350090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazardous Substances Data | 70-55-3(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
p-Toluenesulfonamide price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.08230 | 4-Toluenesulfonamide for synthesis | 70-55-3 | 100g | $27.5 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.08230 | 4-Toluenesulfonamide for synthesis | 70-55-3 | 1kg | $94.5 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.08230 | 4-Toluenesulfonamide for synthesis | 70-55-3 | 25kg | $607 | 2025-07-31 | Buy |
| Sigma-Aldrich | 105902 | p-Toluenesulfonamide reagent grade, 98% | 70-55-3 | 250g | $47.2 | 2025-07-31 | Buy |
| Sigma-Aldrich | 105902 | p-Toluenesulfonamide reagent grade, 98% | 70-55-3 | 1kg | $86.83 | 2025-07-31 | Buy |
p-Toluenesulfonamide Chemical Properties,Uses,Production
Role and purpose
P-toluene sulfonamide is a kind of excellent solid plasticizer used for thermoset plastic. It is suitable for being applied to phenolic resin, melamine resin, urea-formaldehyde resins and polyamide resins. Combination with a small amount can improve workability and make the solidification be uniform, and thus endowing the products with a good gloss. However, P-toluene sulfonamide has no softening effect as the liquid plasticizer, and is incompatible with polyvinyl chloride and vinyl chloride copolymer and is partially compatible with cellulose acetate, cellulose acetate butyrate and cellulose nitrate.
p-Toluene sulfonamide has a low toxicity. It has been approved by the US Food and Drug Administration for being applied into adhesives as food packaging materials.
p-Toluene sulfonamide is briefly called TSH and is commonly used for nickel plating. It can improve the coating structure by the adsorption on the electrode so that it has some degree of surface glossing effect; it is generally not strictly limited for the added amount of brighteners lax; moreover it also has very light effects on the coating characteristics. However, it can only give semi-bright coatings, and the surface gloss is related to the polishing quality of the matrix before plating.
Currently, the brightener agents of nickel plating used is mostly some kinds of organic compounds. And the used amount of these organic compound, although are very little, but with a significant effect. In addition to brightening the coating, it can also largely determine the mechanical properties and chemical properties of the coating. But it must be realized that, since the bright nickel plating solution has been added to the organic brightener, it naturally makes the nickel plating layer contain a relative big amount of organic sulfur and other impurities, thus inevitably enlarging the internal stress, so its mechanical properties is a bitter lower than the conventional nickel-plate, and is prone to crack layer when the plating gets stress; its antirust ability is also worse than the dark nickel. Thus, a single layer of bright nickel is unable to improve the corrosion resistance and mechanical properties of the nickel layer; it must need to form a bi-layer and multilayer nickel or chromium to form a multilayer combination of decorative protective coatings.
When toluene sulfonamide is heated to 105 °C, it will be decomposed and there will be nitrogen released (gas evolution 130 mL/g); p-toluene sulfonamide foaming agents can give a fine foaming with small product shrinkage. It also has a high tear strength and good stability. Thereby, it has a wide range of applications.
The above information is edited by the chemicalbook of Dai xiongfeng.
Uses
1. It is used in the manufacture of dyes, synthetic resins, paints, disinfectants and wood processing brightener.
2. It is used for the manufacture of plasticizers, disinfectants; it can also be used for the production of synthetic resins, paints, and fluorescent dyes.
3. It can be used as primary brightener in the bright nickel plating. It is sued for bright nickel plating for multilayer to obtain uniform bright coating. It has a commonly used amount of 0.2~0.3 g/L.
4. It can be used as plasticizers, also used for synthesis of organics, resins and saccharin.
Production methods
It is obtained by the reaction between toluenesulfonyl chloride and ammonia.
First, add part of HN3 water into the reaction pot, stirring for adding p-toluenesulfonyl chloride with the temperature rising naturally to above 50 °C; after the temperature has dropped, add the remaining ammonia and have reaction for 0.5 h at 85~90 °C. Stop the reaction when the pH reaches 8 to 9. Cool to 20 °C, filter, and wash the filter cake with water to obtain the crude. Then further go through bleaching via activated carbon, alkali dissolution, acid precipitation, rejection filter, drying to get products.
Chemical Properties
White leaflets. Soluble in alcohol; very slightly soluble inwater.Combustible.
Uses
p-Toluenesulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate.
Uses
4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs.
Uses
Used in the manufacture of plasticizer, disinfectant, fungicide, fungicides, wood brightener. Also can be used in the production of synthetic resin, the coating, the fluorescent dye, pharmaceutical, etc.
Definition
ChEBI: A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.
Synthesis Reference(s)
The Journal of Organic Chemistry, 47, p. 4327, 1982 DOI: 10.1021/jo00143a031
Synthetic Communications, 20, p. 293, 1990 DOI: 10.1080/00397919008052297
Synthesis, p. 1031, 1986 DOI: 10.1055/s-1986-31862
General Description
p-Toluenesulfonamide undergoes FeCl3-catalyzed direct substitution reaction with benzylic and allylic alcohols.It is employed as nucleophile in tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction.
Purification Methods
Crystallise the amide from hot water, then from EtOH or Et2O/pet ether. [Beilstein 11 H 104, 11 IV 376.]
p-Toluenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shouguang Nuomeng Chemical Co Ltd. | 536-5119508 18363669993; | export@nuomengchem.com | China | 46 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +86-18124244216 +86-18124244216 | info@upharm.cn | China | 998 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13799 | 58 |
Related articles
- P-Toluenesulfonamide: A Versatile Compound in the Chemical Industry
- P-Toluenesulfonamide (p-TSA) is a vital chemical compound widely used across various industries, particularly in the chemical ....
- Sep 2，2024
View Lastest Price from p-Toluenesulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-30 | p-Toluenesulfonamide
70-55-3
|
US $19.90 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-01-16 | P-Toluenesulfonamide;PTSA;Para Toluenesulphonamide
70-55-3
|
US $3900.00 / ton | 1ton | 99.5% MIn. | 300 tons per month | Shouguang Nuomeng Chemical Co Ltd. | |
 |
2025-12-01 | p-Toluenesulfonamide
70-55-3
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- p-Toluenesulfonamide
70-55-3
- US $19.90 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- P-Toluenesulfonamide;PTSA;Para Toluenesulphonamide
70-55-3
- US $3900.00 / ton
- 99.5% MIn.
- Shouguang Nuomeng Chemical Co Ltd.
-
- p-Toluenesulfonamide
70-55-3
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
70-55-3(p-Toluenesulfonamide )Related Search:
1of4
