LB-80317
- CAS No.
- 441785-24-6
- Chemical Name:
- LB-80317
- Synonyms
- ANA317;ANA 317;ANA-317;LB-80317;[[[1-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphonic acid;Phosphonic acid, P-[[[1-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-
- CBNumber:
- CB43133224
- Molecular Formula:
- C10H14N5O5P
- Molecular Weight:
- 315.22
- MDL Number:
- MFCD34469159
- MOL File:
- 441785-24-6.mol
- TDS File:
- TDS
| FDA UNII | W017G7IF4S |
|---|
LB-80317 Chemical Properties, Uses, Production
Uses
LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment[1][2].
in vivo
Forty percent of the amount of LB80331/LB80317 in the mouse liver is detected as the phosphorylated form. LB80380 is rapidly absorbed and converted to LB80331. LB80317 has a long half-life at steady-state (T1/2=8.3-9.9 hours)[1].
References
[1] Man-Fung Yuen, et al. Pharmacokinetics of LB80331 and LB80317 Following Oral Administration of LB80380, a New Antiviral Agent for Chronic Hepatitis B (CHB), in Healthy Adult Subjects, CHB Patients, and Mice. Antimicrob Agents Chemother. 2009 May;53(5):177 DOI:10.1128/AAC.01290-08
[2] Lung-Yi Mak, et al. Pharmacokinetic Evaluation of Besifovir for the Treatment of HBV Infection. Expert Opin Drug Metab Toxicol. 2018 Jan;14(1):101-106. DOI:10.1080/17425255.2018.1417983
LB-80317 Preparation Products And Raw materials
Raw materials
Preparation Products
LB-80317 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Ningbo Chemrio Chemtech Co,.Ltd. | 0574-27891269 18667892864 | frank.xiaodong@chemriotech.com | China | 3962 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
