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Atorvastatin lactone

Atorvastatin lactone structure

CAS No.: 125995-03-1

Chemical Name:: Atorvastatin lactone

Synonyms: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide;PD-130694;ATORVASTATIN LACTONE;Atorvastatin USP RC H;Atorvastatin calcium-6;Atorvastatin d-Lactone;Atorvastatin Impurity H;LACTONE IMPURITY(IMP-H);(RS) Atorvastatin Lactone;Atorvastatin lactone ,97%

CBNumber:: CB4313438

Molecular Formula:: C33H33FN2O4

Molecular Weight:: 540.62

MDL Number:: MFCD00899262

MOL File:: 125995-03-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:15

Product description	Number	Pack Size	Price
Atorvastatin Related Compound H Pharmaceutical Secondary Standard; Certified Reference Material	PHR1873	30 mg	$793
Atorvastatin Related Compound H United States Pharmacopeia (USP) Reference Standard	1044582	20MG	$1290
Atorvastatin Lactone >95.0%(HPLC)	A3114	25mg	$122
Atorvastatin Lactone >95.0%(HPLC)	A3114	100mg	$362
Atorvastatin lactone ≥95%	20951	1mg	$36
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Atorvastatin lactone Properties

Melting point	103-106°C
alpha	D +26.05° (c = 1 in chloroform)
Boiling point	674.8±55.0 °C(Predicted)
Density	1.24±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	13.39±0.40(Predicted)
form	Solid
color	White to Light Yellow
optical activity	Consistent with structure
Merck	14,864
Major Application	pharmaceutical (small molecule)
InChIKey	OUCSEDFVYPBLLF-KAYWLYCHSA-N
SMILES	Fc1ccc(cc1)c2[n](c(c(c2c5ccccc5)C(=O)Nc4ccccc4)C(C)C)CC[C@H]3OC(=O)C[C@@H](C3)O
FDA UNII	7876IL7J2N
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

WGK 3

HS Code

2933.99.7500

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

Atorvastatin lactone price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1873	Atorvastatin Related Compound H Pharmaceutical Secondary Standard; Certified Reference Material	125995-03-1	30 mg	$793	2026-04-30	Buy
Sigma-Aldrich	1044582	Atorvastatin Related Compound H United States Pharmacopeia (USP) Reference Standard	125995-03-1	20MG	$1290	2026-04-30	Buy
TCI Chemical	A3114	Atorvastatin Lactone >95.0%(HPLC)	125995-03-1	25mg	$122	2026-04-30	Buy
TCI Chemical	A3114	Atorvastatin Lactone >95.0%(HPLC)	125995-03-1	100mg	$362	2026-04-30	Buy
Cayman Chemical	20951	Atorvastatin lactone ≥95%	125995-03-1	1mg	$36	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR1873	30 mg	$793	Buy
1044582	20MG	$1290	Buy
A3114	25mg	$122	Buy
A3114	100mg	$362	Buy
20951	1mg	$36	Buy

Atorvastatin lactone Chemical Properties,Uses,Production

Chemical Properties

Slightly Yellow Solid

Uses

Atorvastatin intermediate as inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation

Uses

Atorvastatin Lactone (Atorvastatin EP Impurity H) is an intermediate of Atorvastatin, a inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation.

Synthesis

134523-03-8

125995-03-1

Calcium salt of (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid (500 mg, 0.413 mmol) was used as a raw material, which was suspended in water (8 mL), EtOAc (4 mL) was added, and the mixture was cooled in an ice bath (4°C). An aqueous 0.2 M HCl solution (4.55 mL, 0.910 mmol) was added slowly and dropwise under vigorous stirring until a clarified solution was formed. The reaction mixture was gradually warmed to room temperature, followed by separation of the organic and aqueous layers. The aqueous layer was extracted with EtOAc (3 x 5 mL), the combined organic layers were washed with brine (5 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resulting foam (469 mg) was dissolved in toluene (20 mL) and the mixture was heated to 0°C and refluxed for 2.5 h under a Dean-Stark apparatus. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. Purification by fast column chromatography (eluent: heptane/EtOAc, gradient from 1:3 to 1:5) afforded the target product 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide (394 mg. (white foamy substance). NMR hydrogen spectrum (400 MHz, CDCl3) δ 7.24-7.10 (m, 9H), 7.09-6.96 (m, 5H), 6.92-6.82 (br s, 1H), 4.57-4.47 (m, 1H), 4.34-4.27 (m, 1H), 4.27-4.16 (m, 1H), 4.09-3.97 (m , 1H), 3.62-3.47 (m, 1H), 2.66 (ABdd, J = 17.7, 4.8 Hz, 1H), 2.55 (ABddd, J = 17.7, 3.4, 1.5 Hz, 1H), 2.11 (d, J = 2.9 Hz, 1H), 1.95-1.82 (m, 1H), 1.81-1.67 (m, 2H) , 1.63-1.57 (m, 1H), 1.56-1.45 (m, 6H).

References

[1] Patent: WO2017/137469, 2017, A1. Location in patent: Page/Page column 62
[2] Patent: CN105085497, 2017, B. Location in patent: Paragraph 0115; 0116; 0117

Atorvastatin lactone Preparation Products And Raw materials

Raw materials

Atorvastatin Atorvastatin calcium Hydrochloric acid Water Ethyl acetate

Preparation Products

Atorvastatin lactone Suppliers

Global( 221)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Guangzhou PI PI BIOTECH INC	+86-86-020-81716320 +8613602409664	Sales@pipitech.com	China	973	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Guangzhou PI PI BIOTECH INC	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Win-Win chemical CO., Limited	58

View Lastest Price from Atorvastatin lactone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-04	5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide 125995-03-1	US $0.00-0.00 / KG	1KG	99%	500	Hangzhou ICH Biofarm Co., Ltd
2025-12-19	Atorvastatin Impurity H(EP) 125995-03-1	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC
2025-12-19	Atorvastatin Impurity E Intermediate	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC

5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
125995-03-1
US $0.00-0.00 / KG
99%
Hangzhou ICH Biofarm Co., Ltd

Atorvastatin Impurity H(EP)
125995-03-1
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

Atorvastatin Impurity E Intermediate
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

Atorvastatin lactone Spectrum

Atorvastatin lactone(125995-03-1)¹HNMR

125995-03-1(Atorvastatin lactone)Related Search:

Phenyl salicylate Diphenyl ether Atorvastatin calcium N-Methyl-2-pyrrolidone Pyrrolidine

PHENYL VALERATE ISOPROPYL LAURATE N-Vinyl-2-pyrrolidone TRIOXSALEN Atorvastatin

tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate Defluoro Atorvastatin Atorvastatin Impurity 40 Isopropyl alcohol Polyvinylpyrrolidone

PHENYL RESIN Phenylacetic acid 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt

1of4

1-[2-[[(2R)-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2α-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-4,N-diphenyl-1H-pyrrole-3-carboxamide Atorvastatin EPIMp H (USP RCH) Atorvastatin EP IMpurity H Atorvastatin Related Compound H (20 mg) (5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide) Diepoxide Atorvastatin Lactone Diepoxide Atorvastatin Calcium Impurity D Atorvastatin Impurity H (RS) Atorvastatin Lactone ATORVASTATIN LACTONE Atorvastatin lactone (EP impurity H) (4R,6R)-6-[2-[2-(4-flfluorophenyl)-5-(1-methylethyl)-3- phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4- hydroxytetrahydro-2H-pyran-2-one Atorvastatin Impurity H(EP) Atorvastatin USP RC H Atorvastatin EP Impurity H (USP RC H)Ator. Lacton Atorvastatin impurity 9/Atorvastatin EP Impurity H/Atorvastatin Lactone/5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide Atorvastatin calcium-6 5-(4-fluorophenyl)-1-(2-((2R,4R) Atorvastatin Calcium Hydrate impurity H Atorvastatin EP Impurity H (Atorvastatin Lactone) 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide Atorvastatin d-Lactone (4R,6R)-6-{2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-4-hydroxytetrahydro-2H-pyran-2-one 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-yl]-3,5-dihydroxyheptanoic acid 1,5-lactone (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5- Atorvastatin Lactone (Atorvastatin EP Impurity H) PD-130694 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]- Atorvastatin lactone ( imp H) USP Atorvastatin Related Compound H Atorvastatin EP Impurity H/ Atorvastatin Related Compound H (Atorvastatin Lactone) Atorvastatin D5 LactoneQ: What is Atorvastatin D5 Lactone Q: What is the CAS Number of Atorvastatin D5 Lactone Q: What is the storage condition of Atorvastatin D5 Lactone Q: What are the applications of Atorvastatin D5 Lactone Atorvastatin LactoneQ: What is Atorvastatin Lactone Q: What is the CAS Number of Atorvastatin Lactone Q: What is the storage condition of Atorvastatin Lactone Q: What are the applications of Atorvastatin Lactone Atorvastatin Related Compound H (1044582)Q: What is Atorvastatin Related Compound H (1044582) Q: What is the CAS Number of Atorvastatin Related Compound H (1044582) AtorvastatinEPImpurityH-d5 Atorvastatin Calcium Trihydrate Impurity H Atorvastatin Calcium Trihydrate EP Impurity H Atorvastatin USP Related Compound H Atorvastatin calcium impurity H 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-carboxamide Atorvastatin EP Impurity H (Atorvastatin USP Related Compound H, Atorvastatin Lactone) LACTONE IMPURITY(IMP-H) (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl Atorvastatin lactone, 10 mM in DMSO Atorvastatin lactone ,97% (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone) Atorvastatin Related Compound H/Atorvastatin Acid - Impurity Q (Sodium Salt) 5-(4-fluorophenyl)-2-(1-methyl)-N,4-dibiphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxy-2H-pyran-2-yl]ethyl]-1H-pyridine-3-carboxamide 125995-03-1 12599-03-1 C33H33FN2O4 Inhibitors Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals