3,5-Dibromo-1H-pyrazole
- CAS No.
- 67460-86-0
- Chemical Name:
- 3,5-Dibromo-1H-pyrazole
- Synonyms
- 3,5-Dibromopyrazole;3,5-dibromo-1H-pyrazole(WXC07881);3,5-Dibromo-1H-pyrazoL;3.5dibromo-1H-pyrazole;3,5-Bibromo-1H-pyrazole;1H-Pyrazole, 3,5-dibromo-
- CBNumber:
- CB43164871
- Molecular Formula:
- C3H2Br2N2
- Molecular Weight:
- 225.87
- MDL Number:
- MFCD00159645
- MOL File:
- 67460-86-0.mol
- MSDS File:
- SDS
| Boiling point | 321.8±22.0 °C(Predicted) |
|---|---|
| Density | 2.419±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 7.76±0.10(Predicted) |
| InChI | InChI=1S/C3H2Br2N2/c4-2-1-3(5)7-6-2/h1H,(H,6,7) |
| InChIKey | UQFIWKBFQXGMJD-UHFFFAOYSA-N |
| SMILES | N1C(Br)=CC(Br)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933199090 |
3,5-Dibromo-1H-pyrazole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR510228 | 3,5-Dibromo-1H-pyrazole 98% | 67460-86-0 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR510228 | 3,5-Dibromo-1H-pyrazole 98% | 67460-86-0 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR510228 | 3,5-Dibromo-1H-pyrazole 98% | 67460-86-0 | 25g | $75 | 2026-06-04 | Buy |
| Apolloscientific | OR510228 | 3,5-Dibromo-1H-pyrazole 98% | 67460-86-0 | 100g | $229 | 2026-06-04 | Buy |
| Activate Scientific | AS95034 | 3,5-Dibromo-1H-pyrazole 97% | 67460-86-0 | 5g | $29 | 2026-06-04 | Buy |
3,5-Dibromo-1H-pyrazole Chemical Properties, Uses, Production
Chemical Properties
3,5-Dibromo-1H-pyrazole is a chemical compound that belongs to the group of c1-c6 alkoxy. It has been shown to be a solid catalyst for copolymerization reactions and also has been used in the synthesis of polymers with ethyl groups, hydroxyl groups, and active methylene groups. Its regulatory properties are related to its valency and stereoisomers. 3,5-Dibromo-1H-pyrazole can be found in Alzheimer's disease as a quaternary ammonium salt.
Uses
3,5-Dibromo-1H-pyrazole is a pale yellow powder and should be stored at 2-8°C under a nitrogen or argon atmosphere. As an important pharmaceutical intermediate, 3,5-Dibromopyrazole can be used to synthesize drugs that selectively bind to and inhibit G12C mutants of KRAS, HRAS, or NRAS, and can be used to treat cancer, particularly cancers characterized by G12C mutations in KRAS, HRAS, or NRAS. As a bromine-containing small organic molecule, it can serve as an important bromine domain in the synthesis of small-molecule BRD4 inhibitors. BRD4 is a bromine-containing protein, and studies have shown that dysregulation of BRD4 expression is associated with the development of various cancers, including leukemia, breast cancer, and colon cancer.
Synthesis Reference(s)
[1] Huettel; Schoen [Justus Liebigs Annalen der Chemie, 1959, vol. 625, p. 55,60.
Safety
3,5-Dibromo-1H-pyrazole is irritating to the skin and eyes. In addition, it is acutely toxic.
Synthesis
The 3,5-dibromo-1H-pyrazole-4-carboxylic acid was treated with trifluorosulfonic anhydride to yield sulphonate, and the bromo-benzene was treated with bromine water, the corresponding Grignard reagent was prepared, then the benzene ring was hydrolyzed, to yield the product 3,5-Dibromo-1H-pyrazole [1].
3,5-Dibromo-1H-pyrazole Preparation Products And Raw materials
3,5-Dibromo-1H-pyrazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Jianzhu Biotechnology Co., Ltd. | 15855184105 | 3150278607@qq.com | China | 64 | 58 |
| Zhenjiang Carbochem Pharmatech Co.,LTD | 0511-81886918 18136818960 | sales4@carbo-chem.com | China | 357 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| SHANGHAI SAGACHEM CO., LTD. | 021-68404722 13816115801 | david_si@shjlchem.com | China | 228 | 58 |
| Fengcheng Meditech (Tianjin)Co., Ltd | 022-59002498-8008; 15122574756 | info@fcmeditech.com | China | 83 | 58 |
| Changzhou Standard Chemicals Ltd. | 0519-85607885 13776800733 | email@standardschem.com | China | 118 | 62 |
| Jinan New Synharmony PharmaTech Co., Ltd. | 13806405245 18560110739 | 1073692093@qq.com | China | 111 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
View Latest Price from 3,5-Dibromo-1H-pyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | 3,5-dibromo-1H-pyrazole
67460-86-0
|
1KG | ≥99.0% | SHANGHAI SAGACHEM CO., LTD. | |||
 |
2026-05-28 | 3,5-Dibromo-1H-pyrazole
67460-86-0
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2020-01-15 | 3.5dibromo-1H-pyrazole
67460-86-0
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3,5-dibromo-1H-pyrazole
67460-86-0
- ≥99.0%
- SHANGHAI SAGACHEM CO., LTD.
-
- 3,5-Dibromo-1H-pyrazole
67460-86-0
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3.5dibromo-1H-pyrazole
67460-86-0
- $9.80
- ≥99%
- Career Henan Chemical Co
