ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- structure

CAS No.: 100823-03-8

Chemical Name:: 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-

Synonyms: TC11;CLT-003;CLT-003 TC11;TC11, 10 mM in DMSO;5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione;2-(2,6-Diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-;1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11;Cyclin dependent kinase,Apoptotic,Mitotic,Inhibitor,Immunomodulatory,Derivative,inhibit,CDK,TC-11,Bcl-2 Family,TC 11,Antitumor,TC11,Phenylphthalimide,Death,Caspase

CBNumber:: CB43176540

Molecular Formula:: C20H22N2O2

Molecular Weight:: 322.4

MDL Number:

MOL File:: 100823-03-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Properties

Boiling point	495.2±55.0 °C(Predicted)
Density	1+-.0.06 g/cm3(Predicted)
form	Solid
pka	0.76±0.20(Predicted)
color	White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	AEA82303	2-(2,6-Diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione	100823-03-8	50mg	$1252.5	2026-06-04	Buy
Biosynth	AEA82303	2-(2,6-Diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione	100823-03-8	100mg	$1743	2026-06-04	Buy
ChemScene	CS-0105753	TC11 99.55%	100823-03-8	5mg	$76	2026-06-04	Buy
ChemScene	CS-0105753	TC11 99.55%	100823-03-8	10mg	$130	2026-06-04	Buy
ChemScene	CS-0105753	TC11 99.55%	100823-03-8	25mg	$271	2026-06-04	Buy

Product number	Packaging	Price	Buy
AEA82303	50mg	$1252.5	Buy
AEA82303	100mg	$1743	Buy
CS-0105753	5mg	$76	Buy
CS-0105753	10mg	$130	Buy
CS-0105753	25mg	$271	Buy

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Chemical Properties, Uses, Production

Uses

TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1][2] during prolonged mitotic arrest.

IC 50

CDK1; Caspase-9; MCL1

References

[1] Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258. DOI:10.1016/j.bbrc.2019.10.119
[2] Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878. DOI:10.1371/journal.pone.0038878

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Suppliers

Global Suppliers ( 24)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9778	55
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Zhejiang Huida Biotech Co., LTD	0571-89903022 18679456698	zilong@hizyme.com	China	8001	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
PureChemland Co.,Ltd.	13540909846 13882008651	3848291069@qq.com	China	3000	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 17801761073	Gsiyu@solarbio.com	China	50460	58

Supplier	Advantage
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Tianjin Kailiqi Biotechnology Co., Ltd.	55
TargetMol Chemicals Inc.	58
Zhejiang Huida Biotech Co., LTD	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Bide Pharmatech Ltd.	58
PureChemland Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Beijing Solarbio Science & Tecnology Co., Ltd.	58

View Latest Price from 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	TC11 100823-03-8	$33.00-119.00		98.10%	10g	TargetMol Chemicals Inc.

TC11
100823-03-8
$33.00-119.00
98.10%
TargetMol Chemicals Inc.

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Spectrum

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-(100823-03-8)¹HNMR

100823-03-8 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-) Related Search:

5HPP-33 N-M-TOLYLPHTHALIMIDE 2-[2-(2,3-Dihydro-1H-indol-1-yl)ethyl]-1H-isoindole-1,3(2H)-dione Quinoline, 1-benzoyl-1,2,3,4-tetrahydro- 2-(4-ethylphenyl)-1-isoindolinone

Benzamide, N-(1-ethyl-2,3-dihydro-2-oxo-1H-indol-5-yl)-2-methyl-

1of2

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- TC11 CLT-003 5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 Cyclin dependent kinase,Apoptotic,Mitotic,Inhibitor,Immunomodulatory,Derivative,inhibit,CDK,TC-11,Bcl-2 Family,TC 11,Antitumor,TC11,Phenylphthalimide,Death,Caspase CLT-003 TC11 TC11, 10 mM in DMSO 2-(2,6-Diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione 100823-03-8