1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-

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1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- manufacturers

  • TC11
  • TC11 pictures
  • $33.00
  • 2026-07-27
  • CAS:100823-03-8
  • Purity: 98.10%
  • Supply Ability: 10g
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-
Synonyms:1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-;TC11;CLT-003;5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11;Cyclin dependent kinase,Apoptotic,Mitotic,Inhibitor,Immunomodulatory,Derivative,inhibit,CDK,TC-11,Bcl-2 Family,TC 11,Antitumor,TC11,Phenylphthalimide,Death,Caspase;CLT-003 TC11;TC11, 10 mM in DMSO
CAS:100823-03-8
MF:C20H22N2O2
MW:322.4
EINECS:
Product Categories:
Mol File:100823-03-8.mol
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Structure
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Chemical Properties
Boiling point 495.2±55.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
form Solid
pka0.76±0.20(Predicted)
color White to yellow
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Usage And Synthesis
UsesTC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1][2] during prolonged mitotic arrest.
IC 50CDK1; Caspase-9; MCL1
References[1] Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258. DOI:10.1016/j.bbrc.2019.10.119
[2] Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878. DOI:10.1371/journal.pone.0038878
1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-(100823-03-8) Related Product Information
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