4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester
- CAS No.
- 492431-11-5
- Chemical Name:
- 4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate;Zinc02563759;1-Boc-4-(6-Chloropyridazin-3-yl);1-Boc-4-(6-chloro-3-pyridazinyl)piperazine;1-Boc-4-(6-chloropyridazin-3-yl)piperazine;1-N-Boc-4-(6-chloropyridazin-3-yl)piperazine;4-(6-Chloropyridazin-3-yl)piperazine, N1-BOC protected;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid t-Butyl Ester;4-(6-chloro-3-pyridazinyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylicacidtert-butylester95%
- CBNumber:
- CB4326962
- Molecular Formula:
- C13H19ClN4O2
- Molecular Weight:
- 298.77
- MDL Number:
- MFCD05864738
- MOL File:
- 492431-11-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 30063 | 1-N-BOC-4-(6-CHLOROPYRIDAZIN-3-YL)PIPERAZINE 97% | 492431-11-5 | 1G | $24 | 2026-04-30 | Buy |
| AK Scientific | B121 | 4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 98% | 492431-11-5 | 1g | $16 | 2026-06-04 | Buy |
| AK Scientific | B121 | 4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 98% | 492431-11-5 | 5g | $62 | 2026-06-04 | Buy |
| Synthonix | B57149 | 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 98% | 492431-11-5 | 250mg | $51 | 2026-05-06 | Buy |
| Synthonix | B57149 | 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 98% | 492431-11-5 | 1g | $57 | 2026-05-06 | Buy |
4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production
Uses
4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid tert-Butyl Ester
Synthesis
141-30-0
57260-71-6
492431-11-5
To 3,6-dichloropyridazine (57.3 g, 385 mmol) and N-BOC-piperazine (71.6 g, 358 mmol) in 1,4-dioxane (250 mL) was added N,N-diisopropylethylamine (66.9 mL, 385 mmol). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (3 L) and washed sequentially with 10% citric acid solution, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from ethyl acetate to give tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate as an off-white solid (101 g, 88% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (ESI): 1H NMR δ 1.25 (9H, s), 3.26-3.47 (8H, m), 6.67 (1H, d, J = 9.6 Hz), 7.00 (1H, d, J = 9.6 Hz); MS (ESI) m/z: 299.0 [M + H]+.
References
[1] Patent: US2015/353542, 2015, A1. Location in patent: Paragraph 0539
[2] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0204; 0205
[3] Patent: WO2017/197051, 2017, A1. Location in patent: Page/Page column 299
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5361 - 5379
[5] Patent: US2005/176722, 2005, A1. Location in patent: Page/Page column 19
4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Kahn Pharmaceutical Co., Ltd. | 021-34979681; 17701870669 | 41513101@qq.com | China | 1789 | 55 |
| Shanghai Qing Cang Chemical Technology Co., Ltd. | 00000000000 | sales@qingcangchem.com | China | 508 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from 4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
492431-11-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-15 | 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
492431-11-5
|
1KG | 99% | 20Tons | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-12-20 | 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
492431-11-5
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
492431-11-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
492431-11-5
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
492431-11-5
- $1.00
- 99%
- Career Henan Chemical Co
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