NSC781406
- CAS No.
- 1676893-24-5
- Chemical Name:
- NSC781406
- Synonyms
- NSC781406;NSC-781406;NSC 781406;NSC781406, 10 mM in DMSO;NSC781406;NSC-781406;NSC 781406;NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR;2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-benzenesulfonamide;Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-
- CBNumber:
- CB43334188
- Molecular Formula:
- C29H27F2N5O5S2
- Molecular Weight:
- 627.68
- MDL Number:
- MOL File:
- 1676893-24-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
NSC781406 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29226 | NSC 781406 ≥98% | 1676893-24-5 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29226 | NSC 781406 ≥98% | 1676893-24-5 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 29226 | NSC 781406 ≥98% | 1676893-24-5 | 10mg | $288 | 2026-04-30 | Buy |
| Biosynth | BSC89324 | NSC781406 | 1676893-24-5 | 1mg | $250 | 2026-06-04 | Buy |
| Biosynth | BSC89324 | NSC781406 | 1676893-24-5 | 5mg | $414.1 | 2026-06-04 | Buy |
NSC781406 Chemical Properties, Uses, Production
Description
NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.
Uses
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.
in vivo
In the xenograft models, treatment with 30 mg/kg of NSC781406 results in statistically significant antitumor activity, with a mean reduction in relative tumor volume ratio of 52%. Sorafenib displays an inhibition ratio of 44% at 50 mg/kg. NSC781406 is well tolerated at 30 mg/kg, with no observed mortality or significant reduction of body weight[1].
IC 50
PI3Kα: 2 nM (IC50); PI3Kγ: 2.7 nM (IC50); PI3Kβ: 9.4 nM (IC50); PI3Kδ: 14 nM (IC50); mTOR: 5.4 nM (IC50)
References
[1] Chen Y, et al. Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma. Bioorg Med Chem. 2016 Mar 1;24(5):957-66. DOI:10.1016/j.bmc.2016.01.008
NSC781406 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| YouCoChem (Beijing) Chemical Technology Co., Ltd. | 18800159827 | youcochem@163.com | China | 163 | 50 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2970 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
