2,4-Difluoro-3-iodoaniline
- CAS No.
- 1437316-91-0
- Chemical Name:
- 2,4-Difluoro-3-iodoaniline
- Synonyms
- HE-CHEMICAL 0400806;2,4-Difluoro-3-iodoaniline;2, 6-dichloro-3-bromoaniline;Benzenamine, 2,4-difluoro-3-iodo-;2,4-difluoro-3-iodoaniline - [AC77843]
- CBNumber:
- CB43367577
- Molecular Formula:
- C6H4F2IN
- Molecular Weight:
- 255
- MDL Number:
- MOL File:
- 1437316-91-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2,4-Difluoro-3-iodoaniline price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS116926 | 2,4-Difluoro-3-iodoaniline 97% | 1437316-91-0 | 1g | $85 | 2026-06-04 | Buy |
| Activate Scientific | AS116926 | 2,4-Difluoro-3-iodoaniline 97% | 1437316-91-0 | 5g | $280 | 2026-06-04 | Buy |
| Activate Scientific | AS116926 | 2,4-Difluoro-3-iodoaniline 97% | 1437316-91-0 | 25g | $991 | 2026-06-04 | Buy |
| Matrix Scientific | 309994 | 2,4-Difluoro-3-iodoaniline | 1437316-91-0 | 1.00g | $76 | 2026-05-19 | Buy |
| Matrix Scientific | 309994 | 2,4-Difluoro-3-iodoaniline | 1437316-91-0 | 5.00g | $124 | 2026-05-19 | Buy |
2,4-Difluoro-3-iodoaniline Chemical Properties, Uses, Production
Uses
2,4-Difluoro-3-iodoaniline is used in the synthetic preparation of purine derivatives that are protein kinase modulators useful in treatment and prevention of protein kinase-mediated diseases.
Synthesis
1145881-54-4
1437316-91-0
General procedure for the synthesis of 2,4-difluoro-3-iodoaniline from 1,3-difluoro-2-iodo-4-nitrobenzene: To a solution of concentrated hydrochloric acid (4 mL) of 1,3-difluoro-2-iodo-4-nitrobenzene (1.14 g, 4 mmol) was added anhydrous stannous chloride (2.71 g, 12 mmol), and the reaction mixture was heated to 50°C and kept for 1 hour. After completion of the reaction, the mixture was diluted with water, neutralized with 5% aqueous sodium hydroxide solution to pH=9, and then extracted with dichloromethane. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2,4-difluoro-3-iodoaniline (0.93 g, 91% yield).1H NMR (CDCl3): δ 6.70-6.93 (2H, m), 6.65 (2H, br).
References
[1] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0501-0503
2,4-Difluoro-3-iodoaniline Preparation Products And Raw materials
2,4-Difluoro-3-iodoaniline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 818 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Yihe Biological Technology Co., Ltd. | 021-68882955 17721395025 | 2423903095@qq.com | China | 5000 | 58 |
| Shanghai Witofly Chemical Co. ,Ltd. | 02150630626 17717886015 | sales@witofly.com | China | 1864 | 55 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2812 | 58 |
