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KGWWHPZQLVVAPT-STTJLUEPSA-N

KGWWHPZQLVVAPT-STTJLUEPSA-N Structure
KGWWHPZQLVVAPT-STTJLUEPSA-N structure
CAS No.
1453868-32-0
Chemical Name:
KGWWHPZQLVVAPT-STTJLUEPSA-N
Synonyms
ENMD 2076;ENMD2076;KGWWHPZQLVVAPT-STTJLUEPSA-N;L-(+) Tartrate salt of ENMD-981693;(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine (2R,3R)-2,3-dihydroxysuccinate(1:1);6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine, 2R,3R-dihydroxybutanedioate;4-Pyrimidinamine, 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)
CBNumber:
CB43561982
Molecular Formula:
C21H25N7.C4H6O6
Molecular Weight:
525.56
MDL Number:
MFCD18633211
MOL File:
1453868-32-0.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:20
Request For Quotation

KGWWHPZQLVVAPT-STTJLUEPSA-N Properties

solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid
color Light brown to khaki
FDA UNII KXQ762CQTH

KGWWHPZQLVVAPT-STTJLUEPSA-N price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22956 ENMD-2076 ≥98% 1453868-32-0 1mg $55 2026-04-30 Buy
Cayman Chemical 22956 ENMD-2076 ≥98% 1453868-32-0 5mg $215 2026-04-30 Buy
Cayman Chemical 22956 ENMD-2076 ≥98% 1453868-32-0 10mg $402 2026-04-30 Buy
Biosynth DIC86832 Enmd-2076 tartrate 1453868-32-0 5mg $250 2026-06-04 Buy
Biosynth DIC86832 Enmd-2076 tartrate 1453868-32-0 10mg $287.9 2026-06-04 Buy
Product number Packaging Price Buy
22956 1mg $55 Buy
22956 5mg $215 Buy
22956 10mg $402 Buy
DIC86832 5mg $250 Buy
DIC86832 10mg $287.9 Buy

KGWWHPZQLVVAPT-STTJLUEPSA-N Chemical Properties,Uses,Production

Uses

ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.

in vivo

ENMD-2076 treatment results in statistically significant, dose dependent inhibition of tumor growth or tumor regression. Moreover, there is no correlation between tumor growth rate and antitumor efficacy, which would conceivably be expected for a mitotic kinase inhibitor, as fast growing (e.g., A375 melanoma) and slow-growing (e.g., HT29 colon carcinoma) tumors are similarly inhibited by ENMD-2076. ENMD-2076 is well tolerated at daily doses up to 302 mg/kg (equivalent to 200 mg/kg of the free base), with no weight loss or signs of morbidity noted in any study at this dose with the exception of the A375 model[1].

IC 50

Aurora A: 1.86 nM (IC50); KDR: 58.2 nM (IC50); Flt-4: 15.9 nM (IC50); FGFR1: 92.7 nM (IC50); FGFR2: 70.8 nM (IC50); PDGFRα: 56.4 nM (IC50); Flt3: 14 nM (IC50)

References

[1] Fletcher GC, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37. DOI:10.1158/1535-7163.MCT-10-0574
[2] Wang X, et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25. DOI:10.1111/j.1365-2141.2010.08248.x

KGWWHPZQLVVAPT-STTJLUEPSA-N Preparation Products And Raw materials

Raw materials

Preparation Products

KGWWHPZQLVVAPT-STTJLUEPSA-N Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Sichuan Vicki Biotechnology Co., Ltd. 18108052721 17743264324 3003848760@qq.com China 2101 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 10000 58
Aladdin Scientific tp@aladdinsci.com United States 50089 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Sichuan Vicki Biotechnology Co., Ltd. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58
Aladdin Scientific 58

1453868-32-0(KGWWHPZQLVVAPT-STTJLUEPSA-N)Related Search:

6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1Z)-2-phenylethenyl]-4-pyrimidinamine 6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine KGWWHPZQLVVAPT-STTJLUEPSA-N RGB-286638 (free base) R-1530
LY3295668 (Synonyms: AK-01)

1of2

KGWWHPZQLVVAPT-STTJLUEPSA-N ENMD 2076;ENMD2076 (E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine (2R,3R)-2,3-dihydroxysuccinate(1:1) L-(+) Tartrate salt of ENMD-981693 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine, 2R,3R-dihydroxybutanedioate 4-Pyrimidinamine, 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) 1453868-32-0