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3-Chloro-7-hydroxy-4-methylcoumarin

3-Chloro-7-hydroxy-4-methylcoumarin structure

CAS No.: 6174-86-3

Chemical Name:: 3-Chloro-7-hydroxy-4-methylcoumarin

Synonyms: Nsc24924;Aids124364;Chlorferone;chlorferron;Aids-124364;AKOS BBS-00008033;Coumaphos alcohol metabolite;3-CHLORO-4-METHYLUMBELLIFERONE;7-Hydroxy-4-methyl-3-chlorocoumarin;3-Chloro-7-hydroxy-4-methylcoumarin

CBNumber:: CB4371760

Molecular Formula:: C10H7ClO3

Molecular Weight:: 210.61

MDL Number:: MFCD00006851

MOL File:: 6174-86-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:46

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3-Chloro-7-hydroxy-4-methylcoumarin Properties

Melting point	240-244 °C (lit.)
Boiling point	405.8±45.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	7.43±0.20(Predicted)
form	Powder
color	White to off-white
λmax	332nm(EtOH)(lit.)
InChI	1S/C10H7ClO3/c1-5-7-3-2-6(12)4-8(7)14-10(13)9(5)11/h2-4,12H,1H3
InChIKey	ODZHLDRQCZXQFQ-UHFFFAOYSA-N
SMILES	CC1=C(Cl)C(=O)Oc2cc(O)ccc12
CAS DataBase Reference	6174-86-3(CAS DataBase Reference)
FDA UNII	EVI89HA9V3
EPA Substance Registry System	2H-1-Benzopyran-2-one, 3-chloro-7-hydroxy-4-methyl- (6174-86-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

TSCA

TSCA listed

HS Code

29329900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

3-Chloro-7-hydroxy-4-methylcoumarin price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	640611	3-Chloro-7-hydroxy-4-methylcoumarin 97%	6174-86-3	1g	$69.4	2026-04-30	Buy
TCI Chemical	C3098	3-Chloro-7-hydroxy-4-methylcoumarin >98.0%(T)	6174-86-3	1g	$119	2026-04-30	Buy
TCI Chemical	C3098	3-Chloro-7-hydroxy-4-methylcoumarin >98.0%(T)	6174-86-3	5g	$432	2026-04-30	Buy
Usbiological	163057	Chlorferon-13C6	6174-86-3	2.5mg	$523	2026-06-03	Buy
Biosynth	FC137950	3-Chloro-7-hydroxy-4-methylcoumarin	6174-86-3	5g	$171.45	2026-06-04	Buy

Product number	Packaging	Price	Buy
640611	1g	$69.4	Buy
C3098	1g	$119	Buy
C3098	5g	$432	Buy
163057	2.5mg	$523	Buy
FC137950	5g	$171.45	Buy

3-Chloro-7-hydroxy-4-methylcoumarin Chemical Properties, Uses, Production

Uses

Labelled Chlorferon is has α-Glucosidase inhibitory antihyperglycemic activity of substituted chromenone derivatives. Also used in the synthesis of fluorogenic substrates for the detection of bacterial β-Galactosidase.

Definition

ChEBI: Chlorferron is an organochlorine compound. It is functionally related to a 4-methylumbelliferone.

Synthesis

609-15-4

108-46-3

6174-86-3

GENERAL STEPS: Resorcinol (2.0 g, 18.2 mmol) was dissolved in dioxane and the solution was cooled to 0 °C. Concentrated sulfuric acid (0.5 mL) was added slowly and dropwise at 25 °C. Subsequently, ethyl 2-chloroacetoacetate (2.8 g, 21.8 mmol) was added and the reaction mixture was heated to 60 °C and maintained at this temperature for 4 hours. After completion of the reaction, the mixture was poured into cold water, the precipitate was collected by filtration and dried under reduced pressure. Finally, the product was purified by recrystallization from methanol to give 3-chloro-7-hydroxy-4-methylcoumarin (6a) as white needle-like crystals.

References

[1] Chemistry - A European Journal, 2012, vol. 18, # 32, p. 9901 - 9910
[2] Synthesis, 2006, # 11, p. 1895 - 1897
[3] Monatshefte fur Chemie, 2008, vol. 139, # 7, p. 805 - 808
[4] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 153 - 165
[5] Tetrahedron Letters, 2006, vol. 47, # 19, p. 3279 - 3281

3-Chloro-7-hydroxy-4-methylcoumarin Preparation Products And Raw materials

Raw materials

Ethyl 2-chloroacetoacetate Resorcinol 1,4-Dioxane Sulfuric acid

Preparation Products

3-Chloro-7-hydroxy-4-methylcoumarin Suppliers

Global Suppliers ( 126)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Santai Labs, Inc.	519-85601385	marketing@santailabs.com	China	891	62
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
Santai Labs, Inc.	62
Shandong Xiya Chemical Co., Ltd	57
Syntechem Co.,Ltd	57
Tianjin heowns Biochemical Technology Co., Ltd.	57
Thermo Fisher Scientific	75

View Latest Price from 3-Chloro-7-hydroxy-4-methylcoumarin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN 6174-86-3	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2022-01-15	3-Chloro-4-methyl-7-hydroxycoumarin 6174-86-3		1KG	97.3%	100 tons	Honest Joy Holdings Limited
2019-07-10	3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN 6174-86-3	$1.00	1KG	99%	1ton	Career Henan Chemical Co

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN
6174-86-3
$1.10
99.00%
Dideu Industries Group Limited

3-Chloro-4-methyl-7-hydroxycoumarin
6174-86-3
$0.00
97.3%
Honest Joy Holdings Limited

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN
6174-86-3
$1.00
99%
Career Henan Chemical Co

3-Chloro-7-hydroxy-4-methylcoumarin Spectrum

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN(6174-86-3)MS 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN(6174-86-3)¹HNMR 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN(6174-86-3)¹³CNMR 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN(6174-86-3)IR1 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN(6174-86-3)IR2

6174-86-3 (3-Chloro-7-hydroxy-4-methylcoumarin) Related Search:

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4-Methylcumarin Coumarin haloxon 6-Chloro-4-hydroxy-7-methylcoumarin 7-(Carboxymethoxy)-3-chloro-4-methylcoumarin

6-Chloro-7-hydroxy-4-methyl-2H-chromen-2-one Cyclohexyl-methyl-phosphinic acid 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl ester 3-Chloro-7-dimethoxythiophosphoryloxy-4-methyl courmain 3-Chloro-6,7-dihydroxy-4-methyl-2H-chromen-2-one Methyl-phosphonic acid 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl ester ethyl ester

Dimethyl-phosphoramidic acid 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl ester ethyl ester Phosphoric acid 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl ester dimethyl ester 3-Chloro-7,8-dihydroxy-4-methyl-2H-chromen-2-one

1of4

3-CHLORO-4-METHYLUMBELLIFERONE 3-CHLORO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 3-chloro-7-hydroxy-4-methyl-2h-1-benzopyran-2-on 3-chloro-7-hydroxy-4-methyl-2-benzopyrone 3-CHLORO-7-HYDROXY-4-METHYL-2H-1-BENZOPYRAN-2-ONE 3-Chloro-4-methyl-7-hydroxycoumarine AKOS BBS-00008033 chlorferron 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN 98% 3-Chloro-4-methyl-7-hydroxy-2H-1-benzopyran-2-one Chlorferone 3-Chloro-4-methyl-7-hydroxycoumarin,96% 2H-1-Benzopyran-2-one, 3-chloro-7-hydroxy-4-methyl- 7-Hydroxy-4-methyl-3-chlorocoumarin Aids124364 Aids-124364 Coumarin, 3-chloro-7-hydroxy-4-methyl- Nsc24924 3-Chloro-7-hydroxy-4-methylcoumarin,3-Chloro-4-methylumbelliferone 3-chloro-7-hydroxy-4-methyl-1-benzopyran-2-one Coumaphos alcohol metabolite 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN ISO 9001：2015 REACH 3-Chloro-7-hydroxy-4-methylcoumarin 6174-86-3 Building Blocks Heterocyclic Building Blocks Coumarins Coumarins