Deferoxamine mesylate

Deferoxamine mesylate Properties

Melting point	148-149°
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
color	white to off-white
Water Solubility	Soluble to 100 mM in water
InChIKey	IDDIJAWJANBQLJ-UHFFFAOYSA-N
SMILES	C(=O)(N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN)CCC(=O)NCCCCCN(O)C(=O)C.S(=O)(=O)(O)C
FDA UNII	V9TKO7EO6K
NCI Drug Dictionary	deferoxamine mesylate
UNSPSC Code	41116107
NACRES	NA.32

Pharmacokinetic data

Protein binding	<10%
Excreted unchanged in urine	22%
Volume of distribution	2-2.5(L/kg)
Biological half-life	6 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	2
RTECS	UG5310000
HS Code	29280000
Storage Class	11 - Combustible Solids
Toxicity	man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.

Deferoxamine mesylate price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001934	Deferoxamine for system suitability European Pharmacopoeia (EP) Reference Standard	138-14-7	15 mg	$241	2026-04-30	Buy
Sigma-Aldrich	PHR3411	Deferoxamine Mesylate certified reference material, pharmaceutical secondary standard	138-14-7	500 mg	$265	2026-04-30	Buy
Sigma-Aldrich	D9533	Deferoxamine mesylate salt powder, ≥92.5% (TLC)	138-14-7	1g	$156	2026-04-30	Buy
Sigma-Aldrich	D0160000	Deferoxamine mesylate salt European Pharmacopoeia (EP) Reference Standard	138-14-7	30 mg	$254	2026-04-30	Buy
Sigma-Aldrich	252750	Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri	138-14-7	1g	$217	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0001934	15 mg	$241	Buy
PHR3411	500 mg	$265	Buy
D9533	1g	$156	Buy
D0160000	30 mg	$254	Buy
252750	1g	$217	Buy

Deferoxamine mesylate Chemical Properties,Uses,Production

Description

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC₅₀ = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.

Chemical Properties

DEFEROXAMINE MESYLATE is white or almost white powder.

Uses

DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

Uses

chelating agent (Fe & Al)

brand name

Desferal (Novartis).

reaction suitability

reagent type: chelator

Biochem/physiol Actions

An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.

Clinical Use

Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload

Veterinary Drugs and Treatments

Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.

Metabolism

When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.

storage

Store at -20°C

References

[1] W L STEINMETZ T O O M R Glick. Modified aca method for determination of iron chelated by deferoxamine and other chelators.[J]. Clinical chemistry, 1980, 26 11: 1593-1597.
[2] JIMMY R. THERIAULT . Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 1: Pages 76-81. DOI: 10.1016/j.bmcl.2011.11.077
[3] PANU JAAKKOLA. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation[J]. Science, 2001, 292 5516. DOI: 10.1126/science.1059796
[4] K. SANDAU. Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide*[J]. The Journal of Biological Chemistry, 2001, 120 1: 39805-39811. DOI: 10.1074/jbc.m107689200
[5] NEUFELD E J. Update on iron chelators in thalassemia.[J]. Hematology. American Society of Hematology. Education Program, 2010: 451-455. DOI: 10.1182/asheducation-2010.1.451
[6] JOSEPH M. HENDRICKS. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis[J]. bioRxiv: the preprint server for biology, 2022, 6 1. DOI: 10.1101/2022.12.14.520445
[7] FENGXIANG WANG . PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ[J]. Cell Chemical Biology, 2022, 29 1: Pages 157-170.e6. DOI: 10.1016/j.chembiol.2021.11.001
[8] DAVID A. ARMENTA . Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein[J]. Cell Chemical Biology, 2022, 29 11: Pages 1588-1600.e7. DOI: 10.1016/j.chembiol.2022.10.006
[9] ALEXANDER BEATTY. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.[J]. ACS Combinatorial Science, 2021: 2244. DOI: 10.1038/s41467-021-22471-y
[10] WANLU DU. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma.[J]. ACS Applied Polymer Materials, 2021: 109848. DOI: 10.1016/j.celrep.2021.109848
[11] PANDIAN NAGAKANNAN . Cathepsin B is an executioner of ferroptosis[J]. Biochimica et biophysica acta. Molecular cell research, 2021, 1868 3: Article 118928. DOI: 10.1016/j.bbamcr.2020.118928
[12] DANIEL M. KREMER. GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron[J]. bioRxiv: the preprint server for biology, 2020, 8 1. DOI: 10.1101/2020.02.28.970228
[13] KIRILL BERSUKER. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis[J]. Nature, 2019, 575 7784: 688-692. DOI: 10.1038/s41586-019-1705-2
[14] JENNIFER YINUO CAO. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.[J]. Cell reports, 2019: 1544-1556.e8. DOI: 10.1016/j.celrep.2019.01.043
[15] ANAGHA SEN. MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1.[J]. PLoS ONE, 2013: e78684. DOI: 10.1371/journal.pone.0078684

Deferoxamine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

Deferoxamine mesylate Suppliers

Global( 302)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Kemaiqi Medical Technology Co., LTD	15910349257 15910349257	245546570@qq.com	China	1564	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
China Langchem Inc.	0086-21-58956006		China	7798	57
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62

Supplier	Advantage
Beijing Kemaiqi Medical Technology Co., LTD	58
J & K SCIENTIFIC LTD.	76
Beijing HwrkChemical Technology Co., Ltd	55
Adamas Reagent, Ltd.	59
LGM Pharma	70
Chemsky（shanghai）International Co.,Ltd.	50
China Langchem Inc.	57
Sinopharm Chemical Reagent Co,Ltd.	79
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62

View Lastest Price from Deferoxamine mesylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-13	Deferoxamine mesylate 138-14-7			0.99		RongNa Biotechnology Co.,Ltd
2026-09-02	DEFEROXAMINE MESYLATE 138-14-7	$2.00-8.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2022-02-19	DeferoxaMine Mesylate 138-14-7		1KG	98.4%	100 tons	Honest Joy Holdings Limited

Deferoxamine mesylate
138-14-7
0.99
RongNa Biotechnology Co.,Ltd

DEFEROXAMINE MESYLATE
138-14-7
$2.00-8.00
99%
Henan Fengda Chemical Co., Ltd

DeferoxaMine Mesylate
138-14-7
$0.00
98.4%
Honest Joy Holdings Limited

Deferoxamine mesylate Spectrum

DEFEROXAMINE MESYLATE(138-14-7)MS DEFEROXAMINE MESYLATE(138-14-7)¹HNMR

138-14-7(Deferoxamine mesylate)Related Search:

Hydroxyurea Deferoxamine AMMONIUM FERRIC CHLORIDE Ammonium ferric sulfate dodecahydrate Ferric ammonium EDTA

Ferrous ammonium sulfate hexahydrate AMMONIUM IRON (III) HEXACYANOFERRATE (II) Ferric ammonium citrate,brown Ammonium iron(III) sulfate Ferric ammonium oxalate

MAFA Ammonium ferric citrate Ferric ammonium oxalate trihydrate Deferoxamine mesylate Nocardamine

ferrimycin A1 MAFA aqueous solution (5%) Deferoxamine Mesylate Salt

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