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H-Thr-NH2 HCl

H-Thr-NH2 HCl structure

CAS No.: 33209-01-7

Chemical Name:: H-Thr-NH2 HCl

Synonyms: Thr-NH2;THR-NH2HCL;L-Thr-NH2·HCl;H-THR-NH2·HCL;H-Thr-NH2 HCl;H-L-THR-NH2 HCL;HCl. H-L-Thr-NH2;THREONINE-NH2 HCL;L-ThreonineamideHCl;L-Threoninamide HCl

CBNumber:: CB4394914

Molecular Formula:: C4H11ClN2O2

Molecular Weight:: 154.59

MDL Number:: MFCD00058288

MOL File:: 33209-01-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:48

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H-Thr-NH2 HCl Properties

storage temp.	Inert atmosphere,Room Temperature
Appearance	White to off-white Solid
optical activity	Consistent with structure

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H302-H312-H315-H319-H331-H335
Precautionary statements	P261-P280-P305+P351+P338-P304+P340-P405-P501

H-Thr-NH2 HCl price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	291114	L-Threonine amide hydrochloride Asreported	33209-01-7	2g	$370	2026-06-03	Buy
Usbiological	291114	L-Threonine amide hydrochloride Asreported	33209-01-7	5g	$655	2026-06-03	Buy
Usbiological	291114	L-Threonine amide hydrochloride Asreported	33209-01-7	10g	$928	2026-06-03	Buy
Usbiological	291114	L-Threonine amide hydrochloride Asreported	33209-01-7	25g	$1323	2026-06-03	Buy
Usbiological	239434	L-Threonine amide hydrochloride 98+%(HPLC) ≥98%(HPLC)		1g	$206	2026-06-03	Buy

Product number	Packaging	Price	Buy
291114	2g	$370	Buy
291114	5g	$655	Buy
291114	10g	$928	Buy
291114	25g	$1323	Buy
239434	1g	$206	Buy

H-Thr-NH2 HCl Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

L-Threonine Amide Hydrochloride is used as a reagent in the synthesis of N-monosubstituted [(pyridin-2-yl)methyl]amine and [(pyrimidin-4-yl)methyl]amine derivatives as transient receptor potential cation channel 3 (TRPV3) modulators.

Synthesis

Benzyl (2R,3S)-(1-carbamoyl-2-hydroxypropyl)carbamate

49705-98-8

33209-01-7

The general procedure for the synthesis of (2S,3R)-2-amino-3-hydroxy-1-oxobutan-2-yl)carbamic acid benzyl ester from (2S,3R)-1-amino-3-hydroxybutyramide hydrochloride is as follows: dissolve N-Cbz-ThrNH2 (504 g, 2 mol) in methanol, followed by addition of 10% Pd/C catalyst (50.4 g, 10 wt%) . The resulting suspension was stirred in hydrogen (1.0 MPa) atmosphere for 12 h at room temperature. Upon completion of the reaction, the Pd/C catalyst was removed by filtration, and the filtrate was evaporated under vacuum to obtain a crude product in the form of a yellow oil. This crude product was redissolved in 3 L of acetone, and HCl solution dissolved in isopropanol (500 mL) was added slowly at 0-5 °C while stirring. The precipitated white solid was collected by filtration and dried under high vacuum (45 °C, 0.1 MPa) to give the final target product 1b 289 g (93.5% yield). The product was analyzed by 1H-NMR (400 MHz, D2O) showing δ 4.15 (p, J = 6.1 Hz, 1H), 3.86 (d, J = 5.2 Hz, 1H), 1.25 (d, J = 6.5 Hz, 3H); and 13C-NMR (101 MHz, D2O) analysis showing δ 170.25, 66.04, 58.40, 18.80. HRMS (ESI-TOF+) analysis showed m/z ([M + H]+) calculated value of 119.0815 (corresponding to C14H11N2O2 + H+) and measured value of 119.0817.

References

[1] Molecules, 2018, vol. 23, # 5,

H-Thr-NH2 HCl Preparation Products And Raw materials

Raw materials

Benzyl (2R,3S)-(1-carbamoyl-2-hydroxypropyl)carbamate Palladium Hydrochloric acid Acetone Isopropyl alcohol

Methanol Hydrogen Activated carbon

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Preparation Products

H-Thr-NH2 HCl Suppliers

Global Suppliers ( 131)

Supplier	Tel	Email	Country	ProdList	Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Spectrum Chemical Manufacturing Corp.	021-021-021-67601398-809-809-809 15221380277	marketing_china@spectrumchemical.com	China	9643	60
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	18201	56
Tianjin Chempharmatech Co.,Ltd.	022-66211079 13212288319	sales@chempharmatech.com	China	944	55
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Spectrum Chemical Manufacturing Corp.	60
Beijing HuaMeiHuLiBiological Chemical	58
9ding chemical ( Shanghai) Limited	56
Tianjin Chempharmatech Co.,Ltd.	55
HBCChem, Inc.	60
Bide Pharmatech Ltd.	60

View Latest Price from H-Thr-NH2 HCl manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-17	(2S,3R)-2-amino-3-hydroxybutanamide,hydrochloride 33209-01-7	$1.00	1KG	98% HPLC	10 tons	Career Henan Chemical Co

(2S,3R)-2-amino-3-hydroxybutanamide,hydrochloride
33209-01-7
$1.00
98% HPLC
Career Henan Chemical Co

H-Thr-NH2 HCl Spectrum

H-THR-NH2 HCL(33209-01-7)¹HNMR

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H-THR-NH2·HCL [R-(R*,S*)]-2-amino-3-hydroxybutyramide monohydrochloride L-Threoninamide monohydrochloride L-Threoninamide HCl THR-NH2HCL L-ThreonineamideHCl H-Thr-NH2·HCl L-threonine aMide hydrochloride (2S,3R)-2-Amino-3-hydroxybutanamide hydrochloride 2-Amino-3-hydroxy-(2S,3R)butanamide monohydrochloride L-Thr-NH2·HCl -2-Amino-3-hydroxybutanamide hydrochloride L-Threonine amide hydrochloride≥ 98%(HPLC) H-L-THR-NH2 HCL L-Threonine amide. HCl salt H-Thr-Nh2 Hydrochloride L-THREONINE AMIDE HYDROCHLORIDE L-THREONINAMIDE HYDROCHLORIDE THREONINE-NH2 HCL THREONINE AMIDE HYDROCHLORIDE TIANFU CHEM--H-THR-NH2 HCL Thr-NH2 HCl. H-L-Thr-NH2 H-Thr-NH2 HCl 33209-01-7 Threonine [Thr, T] Amino Acids