ChemicalBook >> CAS DataBase List >>(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE structure

CAS No.: 194032-32-1

Chemical Name:: (S)-1-BOC-2-METHYL-[1,4]DIAZEPANE

Synonyms: diazepane;tert-butyl (S)-3-methyl-1,4-diazepane-1-carboxylate;(S)-tert-butyl-3-Methyl-1,4-diazepane-1-carboxylate;tert-butyl (3S)-3-methyl-1,4-diazepane-1-carboxylate;(S)-Hexahydro-3-methyl-1H-1,4-Diazepine-1-carboxylic acid tert-butyl ester;(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE;(S)-1-Boc-3-methyl-[1,4]diazepane;(S)-tert-butyl 3-Methyl-1,4-diazepane-;(S)-tert-butoxyl-3-Methyl-1-carbonyl-1,4-diazepine;(3S)-tert-butoxyl-3-Methyl-1-carbonyl-1,4-diazepine

CBNumber:: CB4405988

Molecular Formula:: C11H22N2O2

Molecular Weight:: 214.3

MDL Number:: MFCD08437660

MOL File:: 194032-32-1.mol

MSDS File:: SDS

Last updated:2026-05-28 02:32:47

Product description	Number	Pack Size	Price
Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine	H2034-91T	10mg	$482
Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine	TRC-H294185-10MG	10mg	$193
Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine	TRC-H294185-100MG	100mg	$1515
(S)-tert-Butyl 3-methyl-1,4-diazepane-1-carboxylate	202091	1.00g	$2622
tert-butyl (3S)-3-methyl-1,4-diazepane-1-carboxylate 97%	B22096	1g	$65
More product size

Request For Quotation

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE Properties

Boiling point	288℃
Density	0.980
Flash point	128℃
storage temp.	2-8°C(protect from light)
solubility	soluble in Chloroform, DMSO
pka	10.42±0.40(Predicted)
form	Oil
color	Yellow
optical activity	8.6925°(C=1g/100ml CHCL3)
InChI	InChI=1S/C11H22N2O2/c1-9-8-13(7-5-6-12-9)10(14)15-11(2,3)4/h9,12H,5-8H2,1-4H3/t9-/m0/s1
InChIKey	GDTFCUXOVITPHU-VIFPVBQESA-N
SMILES	N1(C(OC(C)(C)C)=O)CCCN[C@@H](C)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	H2034-91T	Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine	194032-32-1	10mg	$482	2026-06-03	Buy
TRC	TRC-H294185-10MG	Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine	194032-32-1	10mg	$193	2026-06-03	Buy
TRC	TRC-H294185-100MG	Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine	194032-32-1	100mg	$1515	2026-06-03	Buy
Matrix Scientific	202091	(S)-tert-Butyl 3-methyl-1,4-diazepane-1-carboxylate	194032-32-1	1.00g	$2622	2026-05-18	Buy
Synthonix	B22096	tert-butyl (3S)-3-methyl-1,4-diazepane-1-carboxylate 97%	194032-32-1	1g	$65	2026-05-06	Buy

Product number	Packaging	Price	Buy
H2034-91T	10mg	$482	Buy
TRC-H294185-10MG	10mg	$193	Buy
TRC-H294185-100MG	100mg	$1515	Buy
202091	1.00g	$2622	Buy
B22096	1g	$65	Buy

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE Chemical Properties,Uses,Production

Chemical Properties

Yellow Oil

Uses

Hexahydro-2(S)-methyl-4-(t-butoxycarboxyl)-1,4-diazepine (cas# 194032-32-1) is a compound useful in organic synthesis.

Synthesis

(S)-tert-Butyl 3-methyl-4-((2-nitrophenyl)sulfonyl)-1,4-diazepane-1-carboxylate

949109-36-8

194032-32-1

（Steps for the synthesis of (S)-3-methyl-1,4-diazepane-1-carboxylic acid tert-butyl ester: 1. tert-Butyl (S)-3-methyl-4-((2-nitrophenyl)sulfonyl)-1,4-diazepane-1-carboxylate (2.60 kg, 6.51 mol) was dissolved in acetonitrile (20 L). 2. Potassium carbonate (1.79 kg, 13.0 mol) was added to the above solution. 3. Benzothiophenol (2.15 kg, 19.5 mol) was slowly added at a controlled internal temperature of 20 °C or lower for 6 h. After addition, the solution was dissolved in acetonitrile (20 L) at 20 °C or lower. 4. After addition, the reaction mixture was continued to be stirred at 20 °C for 18 hours. 5. The reaction was monitored by thin layer chromatography (TLC) to confirm complete consumption of the feedstock, the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. 6. 6. The concentrated residue was dissolved in ice water and the pH was adjusted to 3 with 2N hydrochloric acid, followed by washing with ethyl acetate. 7. The aqueous layer was alkalized to pH 9 with potassium carbonate and extracted with ethyl acetate. 8. The organic layers were combined, dried with magnesium sulfate, filtered and concentrated under reduced pressure to give a yellow oily target product (1.20 kg, 85.7% yield). 9. The chemical purity of the product was 97.5% by gas chromatography analysis. 10. The product was converted to a methylsilyl chloride derivative and the optical purity was determined to be 99.9% ee. 11. The overall yield from (S)-(+)-2-amino-1-propanol to tert-butyl (S)-3-methyl-1,4-diazepane-1-carboxylate was 45.2%. 12. The structure of the product was confirmed by 1H-NMR (DMSO-d6, 100 °C), δ: 0.94 (d, J = 6.3 Hz, 3H), 1.40 (s, 9H), 1.53-1.63 (m, 1H), 1.69-1.78 (m, 1H), 2.42-2.49 (m, 1H), 2.60-2.68 (m, 1H). 2.70-2.79 (m, 1H), 2.97 (ddd, J = 14.0, 4.6, 4.6 Hz, 1H), 3.17 (ddd, J = 14.0, 7.7, 5.8 Hz, 1H), 3.54 (ddd, J = 14.0, 6.3, 5.8 Hz, 1H), 3.60 (ddd, J = 14.0, 4.6 Hz, 1H) .

References

[1] Synthesis (Germany), 2012, vol. 44, # 20, p. 3171 - 3178
[2] Patent: US2013/144054, 2013, A1. Location in patent: Paragraph 0084; 0085

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE Preparation Products And Raw materials

Raw materials

(S)-1-benzyl 4-tert-butyl 2-methyl-1,4-diazepane-1,4-dicarboxylate (S)-tert-Butyl 3-methyl-4-((2-nitrophenyl)sulfonyl)-1,4-diazepane-1-carboxylate Potassium carbonate Acetonitrile Thiophenol

Preparation Products

Ripasudil Hydrochloride

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9542	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
TianYuan Pharmaceutical CO.,LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58

View Lastest Price from (S)-1-BOC-2-METHYL-[1,4]DIAZEPANE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-05	(S)-tert-butyl 3-Methyl-1,4-diazepane-1-carboxylate 194032-32-1		25KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-01	(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE 194032-32-1		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2019-09-02	(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE 194032-32-1	$7.00	1KG	99%		Career Henan Chemical Co

(S)-tert-butyl 3-Methyl-1,4-diazepane-1-carboxylate
194032-32-1
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE
194032-32-1
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE
194032-32-1
$7.00
99%
Career Henan Chemical Co

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE Spectrum

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE(194032-32-1)¹HNMR

194032-32-1((S)-1-BOC-2-METHYL-[1,4]DIAZEPANE)Related Search:

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE

(S)-1-BOC-2-METHYL-[1,4]DIAZEPANE (S)-Hexahydro-3-methyl-1H-1,4-Diazepine-1-carboxylic acid tert-butyl ester (3S)-tert-butoxyl-3-Methyl-1-carbonyl-1,4-diazepine (3S)-Hexahydro-3-Methyl-1H-1,4-diazepine-1-carboxylic Acid 1,1-DiMethylethyl Ester (S)-tert-butoxyl-3-Methyl-1-carbonyl-1,4-diazepine (S)-1-Boc-3-methyl-[1,4]diazepane tert-butyl (S)-3-methyl-1,4-diazepane-1-carboxylate 1H-1,4-Diazepine-1-carboxylic acid, hexahydro-3-methyl-, 1,1-dimethylethyl ester, (3S)- 2-Methyl-2-propanyl3-methyl-1,4-diazepane-1-carboxylate 1H-1,4-Diazepine-1-carboxylic acid, hexahydro-3-methyl-, 1,1-dimethylethyl ester, (S)- Hexahydro-2(S)-methyl-4-(tert-butoxycarboxyl)-1,4-diazepine (S)-Hexahydro-3-methyl-1H-1,4-Diazepine-1-carboxylic acid te... 1,1-Dimethylethyl (3S)-hexahydro-3-methyl-1H-1,4-diazepine-1-carboxylate (S)?-1-Boc-hexahydro-?3-?methyl-1H-?1,?4-?diazepine (S)-tert-butyl 3-Methyl-1,4-diazepane- tert-butyl (3S)-3-methyl-1,4-diazepane-1-carboxylate - [B22096] (S)-Tert-buty1-3-Methy1-1,4-diazepane-1-carboxylate tert-Butyl (3S)-hexahydro-3-methyl-1H-1,4-diazepin-1-carboxylate (S)-tert-butyl-3-Methyl-1,4-diazepane-1-carboxylate diazepane tert-butyl (3S)-3-methyl-1,4-diazepane-1-carboxylate 194032-32-1 Chiral Reagents