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4-(2-Aminoethyl)morpholine

4-(2-Aminoethyl)morpholine structure

CAS No.: 2038-03-1

Chemical Name:: 4-(2-Aminoethyl)morpholine

Synonyms: 2-morpholinoethan-1-amine;4-MORPHOLINEETHANAMINE;Morpholinoethylamine;2-morpholin-4-ylethanamine;2-(4-Morpholinyl)ethanamine;2-(4-Morpholinyl)ethylamine;Morpholine, 4-(2-aminoethyl)-;RARECHEM AL BW 0412;LM11A 31 Impurity 1;2-Morpholinoethylami

CBNumber:: CB4409865

Molecular Formula:: C6H14N2O

Molecular Weight:: 130.19

MDL Number:: MFCD00006182

MOL File:: 2038-03-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:38:46

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4-(2-Aminoethyl)morpholine Properties

Melting point	24 °C
Boiling point	205 °C(lit.)
Density	0.992 g/mL at 25 °C(lit.)
refractive index	n20/D 1.476(lit.)
Flash point	347 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Chloroform, Methanol
form	Liquid After Melting
pka	pK1: 4.06(+2);pK2: 9.15(+1) (25°C)
color	Clear colorless to pale yellow
Water Solubility	soluble
Sensitive	Air Sensitive
BRN	104378
Stability	Air Sensitive
InChI	1S/C6H14N2O/c7-1-2-8-3-5-9-6-4-8/h1-7H2
InChIKey	RWIVICVCHVMHMU-UHFFFAOYSA-N
SMILES	NCCN1CCOCC1
CAS DataBase Reference	2038-03-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	T92F2H779P
NIST Chemistry Reference	4-Morpholineethanamine(2038-03-1)
EPA Substance Registry System	4-Morpholineethanamine (2038-03-1)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314-H317

Precautionary statements

P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,T

Risk Statements

22-34-43-24-40-23/24/25

Safety Statements

26-36/37/39-45-22

RIDADR

UN 2735 8/PG 2

WGK Germany

RTECS

QD7350000

Hazard Note

Toxic

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29349990

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B
Skin Sens. 1

Toxicity

guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.

REACH Registrations

Active

NFPA 704

	2
		0

4-(2-Aminoethyl)morpholine price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A55004	4-(2-Aminoethyl)morpholine 99%	2038-03-1	5G	$59.8	2026-04-30	Buy
Sigma-Aldrich	A55004	4-(2-Aminoethyl)morpholine 99%	2038-03-1	25G	$94	2026-04-30	Buy
Sigma-Aldrich	A55004	4-(2-Aminoethyl)morpholine 99%	2038-03-1	100G	$210	2026-04-30	Buy
TCI Chemical	A0883	4-(2-Aminoethyl)morpholine >98.0%(GC)(T)	2038-03-1	25g	$34	2026-04-30	Buy
TCI Chemical	A0883	4-(2-Aminoethyl)morpholine >98.0%(GC)(T)	2038-03-1	100g	$93	2026-04-30	Buy

Product number	Packaging	Price	Buy
A55004	5G	$59.8	Buy
A55004	25G	$94	Buy
A55004	100G	$210	Buy
A0883	25g	$34	Buy
A0883	100g	$93	Buy

4-(2-Aminoethyl)morpholine Chemical Properties, Uses, Production

Chemical Properties

clear colorless to pale yellow liq. after melting

Uses

4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II).

Uses

4-(2-Aminoethyl)morpholine is widely used in biomedical applications as this moiety serves as an important lysosome-targeting group. Some of its applications include:

Synthesis of the lysosome-targetable fluorescent probe for hydrogen sulfide imaging in living cells.
Synthesis of 1,8-naphthalimide conjugated Troger′s bases as deoxyribonucleic acid (DNA) targeting fluorescent probe.
Synthesis of intramolecular charge transfer-photoinduced electron transfer-fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe for monitoring pH changes in living cells.
It is also used as a precursor to synthesize a variety of antimicrobial agents.

Definition

ChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 1805, 1991 DOI: 10.1021/jm00110a008

Synthesis

5807-02-3

2038-03-1

General procedure for the synthesis of N-(2-aminoethyl)morpholine from 2-morpholinoacetonitrile: LiAlH4 (3.19 g, 84 mmol) was added to anhydrous THF (35 mL) in a single step under ice bath conditions. The reaction mixture was stirred at 0 °C for 20 min, followed by the dropwise addition of 2-morpholino-substituted acetonitrile (3.50 g, 28 mmol) to a solution of anhydrous THF (10 mL). After the dropwise addition, the reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to 0 °C and water (20 mL) was slowly added to quench the reaction. After filtration to remove insoluble material, the filtrate was concentrated in vacuum to give N-(2-aminoethyl)morpholine as a yellow oil (2.62 g, 72% yield).

References

[1] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00363
[2] Patent: US2015/87639, 2015, A1. Location in patent: Paragraph 0650
[3] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 146
[4] Bulletin de la Societe Chimique de France, 1955, p. 218
[5] Patent: CN108658937, 2018, A. Location in patent: Paragraph 0151; 0152; 0231; 0232

4-(2-Aminoethyl)morpholine Preparation Products And Raw materials

Raw materials

Morpholinoacetonitrile Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate Acetamide, 2-amino-N-[2-(4-morpholinyl)ethyl]- Carbamic acid, N-[2-(4-morpholinyl)ethyl]-, 2,2,2-trifluoroethyl ester 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide 4-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-ethyl)-morpholine

4-[2-(4-Morpholino)ethyl]-3-thiosemicarbazide 4-[2-(Dimethylamino)ethyl]morpholine

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4-(2-Aminoethyl)morpholine Suppliers

Global Suppliers ( 260)

Supplier	Tel	Email	Country	ProdList	Advantage
Yangzhou Prince Chemical Co., Ltd	0514-84248359 13328140016;15052570758;15949050037	sales@princechem.com	China	99	58
Yangzhou Princechem Co.,Ltd	18921928333	david@princechem.com	China	498	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Yangzhou Prince Chemical Co., Ltd	58
Yangzhou Princechem Co.,Ltd	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61

View Latest Price from 4-(2-Aminoethyl)morpholine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	4-(2-Aminoethyl)morpholine 2038-03-1	$1.00	1kg	98%	100KG	Career Henan Chemical Co

4-(2-Aminoethyl)morpholine
2038-03-1
$1.00
98%
Career Henan Chemical Co

4-(2-Aminoethyl)morpholine Spectrum

4-(2-Aminoethyl)morpholine(2038-03-1)MS 4-(2-Aminoethyl)morpholine(2038-03-1)¹HNMR 4-(2-Aminoethyl)morpholine(2038-03-1)¹³CNMR 4-(2-Aminoethyl)morpholine(2038-03-1)IR1 4-(2-Aminoethyl)morpholine(2038-03-1)IR2 4-(2-Aminoethyl)morpholine(2038-03-1)Raman

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4-[2-(4-Morpholino)ethyl]-3-thiosemicarbazide 4-(2-aminopropyl)morpholine Morpholinoacetmorpholide

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LABOTEST-BB LT02100621 4-(2-AMINOETHYL)MORPHOLINE 2-MORPHOLINOETHYLAMINE 2-MORPHOLIN-4-YL-ETHYLAMINE 2-(4-MORPHOLINO)ETHYLAMINE 4-Morpholineethaneamine 2-(4-MORPHOLINO)ETHYLAMINE 97% 4-(2-Aminoethyl)morpholine, 98+% 2-(4-Morpholino)ethylamine, 98+% 2-Morpholinoethylami 4-Morpholineethylamine 4-(2-AMinoethyl)Morpholine, 99% 100GR 4-(2-Aminoethyl)morpholine ,99% Morpholine-4-ethanamine 2-(N-Morpholino)ethylaMine RARECHEM AL BW 0412 N-AMINOETHYL MORPHOLINE N-(2-AMINOETHYL)MORPHOLINE 1-Amino-2-morpholinoethane 2-(4-Morpholinyl)ethanamine 2-(4-Morpholinyl)ethylamine 4-(2-aminoethyl)-morpholin beta-Aminoaethyl-morpholin beta-Morpholinoethylamine Morpholinoethylamine N-(beta-Aminoethyl)morpholine N-2-Aminoethylmorfolin 2-morpholin-4-ylethanamine 4-(2-Aminoethyl)morpholine > LM11A 31 Impurity 1 4-Morpholineethanamine (9CI, ACI) 2-Aminoethyl morpholine 2-morpholinoethan-1-amine 4-MORPHOLINEETHANAMINE Morpholine, 4-(2-aminoethyl)- 2038-03-1 2038-3-1 203-83-1 AMINE Building Blocks Heterocyclic Building Blocks Morpholines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Morpholines/Thiomorpholines Building Blocks Heterocyclic Building Blocks Morpholines