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2-Morpholinoethyl isocyanide

CAS No.
78375-48-1
Chemical Name:
2-Morpholinoethyl isocyanide
Synonyms
MEI;SKL087;2-Morpholinoethyl is;Morpholino ethyl isocyanide;2-MORPHOLINOETHYL ISOCYANIDE;2-Morpholino-ethyl-isocyanate;4-(2-ISOCYANOETHYL)MORPHOLINE;Morpholinyl-4-ethylisocyanid-2;4-(2-Isocyanatoethyl)morpholine;MEI 2-MORPHOLINOETHYL ISOCYANIDE
CBNumber:
CB0321752
Molecular Formula:
C7H12N2O
Molecular Weight:
140.19
MDL Number:
MFCD00040506
MOL File:
78375-48-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:26:27

2-Morpholinoethyl isocyanide Properties

Boiling point 72-73 °C0.7 mm Hg(lit.)
Density 1.017 g/mL at 20 °C(lit.)
refractive index n20/D 1.469
Flash point 110 ºC
storage temp. -20°C
form liquid
BRN 4666990
InChI InChI=1S/C7H12N2O/c1-8-2-3-9-4-6-10-7-5-9/h2-7H2
InChIKey MFRZPLYKVDHOSN-UHFFFAOYSA-N
SMILES C(N1CCOCC1)C[N+]#[C-]
CAS DataBase Reference 78375-48-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319-H335
Precautionary statements  P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T
Risk Statements  23/24/25-36/37/38
Safety Statements  26-36/37-45
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
F  10-21
HazardClass  6.1(b)
PackingGroup  III
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

2-Morpholinoethyl isocyanide price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 69893 2-Morpholinoethyl isocyanide ≥98.0% (GC) 78375-48-1 10ml $176 2026-04-30 Buy
Sigma-Aldrich 69893 2-Morpholinoethyl isocyanide ≥98.0% (GC) 78375-48-1 50ml $842 2026-04-30 Buy
Adipogen Life Sciences CDX-M0701-L025 2-Morpholinoethyl isocyanide ≥98%(GC) 78375-48-1 25ml $325 2026-05-06 Buy
Adipogen Life Sciences CDX-M0701-L010 2-Morpholinoethyl isocyanide ≥98%(GC) 78375-48-1 10ml $163 2026-05-06 Buy
Ambeed A302796 2-Morpholinoethylisocyanide 95% 78375-48-1 1g $64 2026-06-05 Buy
Product number Packaging Price Buy
69893 10ml $176 Buy
69893 50ml $842 Buy
CDX-M0701-L025 25ml $325 Buy
CDX-M0701-L010 10ml $163 Buy
A302796 1g $64 Buy

2-Morpholinoethyl isocyanide Chemical Properties, Uses, Production

Uses

2-Morpholinoethyl isocyanide can be used for the synthesis of:

  • Nitrogen acyclic carbene (NAC) complexes to be used as catalysts for the synthesis of phenol and hydration of alkynes.
  • Variety of imidazo[1,2-a]pyridines and α-acylaminoamides by Ugi condensation reaction.
  • 2-Aminobenzoxazoles and 3-aminobenzoxazines having important therapeutic activities.

It can also be used as a ligand in bis-cyclometalated iridium complexes for the organic light emitting diodes (OLEDs).

Synthesis

2-Morpholinoethyl isocyanide is prepared by the reaction of 2-morpholinoethylamine with Formic Acid in boiling toluene with a water separator, to yield the formamide which is treated either with Phosgene and Triethylamine in CH2Cl2 or with Phosphorus Oxychloride and Diisopropylamine. The use of diisopropylamine as base is favored as yields are improved, typically to 68%. Trichloroacetic Anhydride has also been used as an alternative for COCl2, giving a yield of 74%.

78375-50-5
78375-48-1
Synthesis of 2-Morpholinoethyl isocyanide from Formamide, N-[2-(4-morpholinyl)ethyl]-

2-Morpholinoethyl isocyanide Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 75)
Supplier Tel Email Country ProdList Advantage
Wuhan EEChem Technologies Co., Ltd 0711-3617768 13308685235 lihongcai4360@sina.com China 1542 55
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29975 65
Shanghai Meishui Chemical Technology Co., Ltd 021-60549325 18616193163 China 4518 56
Tianjin Olefin Pharmaceutical Co., Ltd. 18202662021 18522876413 2781212171@qq.com China 313 56
Shanghai Xingui Biotechnology Co., Ltd. 15121041756 xingui2022@126.com China 9949 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80

View Latest Price from 2-Morpholinoethyl isocyanide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Morpholinoethyl isocyanide pictures 2021-08-12 2-Morpholinoethyl isocyanide
78375-48-1
$10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Morpholino ethyl isocyanide Morpholine, 4-(2-isocyanoethyl)- MEI 2-MORPHOLINOETHYL ISOCYANIDE Morpholinyl-4-ethylisocyanid-2 4-(2-Isocyanatoethyl)morpholine 2-Morpholinoethyl is 2-Morpholinoethyl isocyanide >=98.0% (GC) 2-MORPHOLINOETHYL ISOCYANIDE 1-N-(2-ISOCYANOETHYL)-MORPHOLINE 4-(2-ISOCYANOETHYL)MORPHOLINE 2-Morpholino-ethyl-isocyanate SKL087 MEI 78375-48-1 Building Blocks Heterocyclic Building Blocks Morpholines Nitro / Nitriles