ChemicalBook >> CAS DataBase List >>1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one structure

CAS No.: 374101-64-1

Chemical Name:: 1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one

Synonyms: NR2F1 agonist 1;1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one;Spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6(4H),1'-cyclohexan]-5(7H)-one, 1-(ethylthio)-4-(2-phenylethyl)-

CBNumber:: CB44147806

Molecular Formula:: C28H30N4OS

Molecular Weight:: 470.63

MDL Number:

MOL File:: 374101-64-1.mol

MSDS File:: SDS

Last updated:2026-07-16 07:06:08

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1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one Properties

Boiling point	719.9±70.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
pka	1.47±0.20(Predicted)
form	Solid
color	Off-white to light yellow

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0652472	NR2F1 agonist 1 99.06%	374101-64-1	5mg	$769	2026-06-04	Buy
ChemScene	CS-0652472	NR2F1 agonist 1 99.06%	374101-64-1	10mg	$1246	2026-06-04	Buy
ChemScene	CS-0652472	NR2F1 agonist 1 99.06%	374101-64-1	25mg	$2492	2026-06-04	Buy
ChemScene	CS-0652472	NR2F1 agonist 1 99.06%	374101-64-1	50mg	$3987	2026-06-04	Buy
aablocks	AA02DHRP	NR2F1 agonist 1 >98%	374101-64-1	5mg	$824	2026-06-03	Buy

Product number	Packaging	Price	Buy
CS-0652472	5mg	$769	Buy
CS-0652472	10mg	$1246	Buy
CS-0652472	25mg	$2492	Buy
CS-0652472	50mg	$3987	Buy
AA02DHRP	5mg	$824	Buy

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one Chemical Properties, Uses, Production

Uses

NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model[1].

in vivo

NR2F1 agonist 1 (0.5 mg/kg/day; i.p.; 3 weeks) inhibits inhibits primary tumor growth and metastatic growth in lungs in mouse models^[1].

Animal Model:	BALB/c nu/nu mice bearing GFP-tagged T-HEp3 PDX cells^[1]
Dosage:	0.5 mg/kg/day
Administration:	Intraperitoneal injection; injected for 3 weeks or for 1 week followed by DMSO for 2 weeks
Result:	Did not induce apoptosis of proliferating primary tumor cells, but exhibited metastasis inhibitory effect against T-HEp3 cells.

References

[1] Khalil BD, et al. An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy. J Exp Med. 2022 Jan 3;219(1):e20210836. DOI:10.1084/jem.20210836

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from 1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-15	NR2F1 agonist 1 374101-64-1	$1670.00-2800.00			10g	TargetMol Chemicals Inc.

NR2F1 agonist 1
374101-64-1
$1670.00-2800.00
TargetMol Chemicals Inc.

374101-64-1 (1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one) Related Search:

SS-RJW100 Ethyl2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate Anti-cancer compound library 4(1H)-Quinazolinone, 2,3-dihydro-2-(2-naphthalenyl)-6-(trifluoromethoxy)-, (2S)- Ethanone, 1-[3'-[1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]-

4,6-Dioxa-10-aza-5-phosphatridecanoic acid, 2-amino-5,8-dihydroxy-3-methyl-11-oxo-13-[3-(undecyloxy)phenyl]-, 5-oxide, (2S,3S,8R)-

1of2

1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one Spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6(4H),1'-cyclohexan]-5(7H)-one, 1-(ethylthio)-4-(2-phenylethyl)- NR2F1 agonist 1 374101-64-1